- Oct4 and Klf4 Reprogram Dermal Papilla Cells Into Induced Pluripotent Stem Cells
[作者:Tsai, SY; Clavel, C; Kim, S; Ang, YS; Grisanti, L; Lee, DF; Kelley, K; Rendl, M,期刊:Stem Cells, 页码:221-228 , 文章类型: Article,,卷期:2010年28-2]
- Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells by only four transcription factors (Oct4, Sox2, Klf4, and c-Myc) has great potential for tissue-specific regenerative therapies, eliminating...
- Generation of Histocompatible Androgenetic Embryonic Stem Cells Using Spermatogenic Cells
[作者:Zhao, QG; Wang, JL; Zhang, Y; Kou, ZH; Liu, S; Gao, SR,期刊:Stem Cells, 页码:229-239 , 文章类型: Article,,卷期:2010年28-2]
- Androgenetic embryonic stem (aES) cells, produced by pronuclear transplantation, offer an important autologous pluripotent stem cell source. However, the isolation of aES cells, particularly individual-specific aES cells...
- Human Embryonic Stem Cell Lines and Their Use in International Research
[作者:Loser, P; Schirm, J; Guhr, A; Wobus, AM; Kurtz, A,期刊:Stem Cells, 页码:240-246 , 文章类型: Article,,卷期:2010年28-2]
- Research in human pluripotent stem cells, including human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC), is one of the most dynamic research fields. Despite the high public attention, espec...
- A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells
[作者:Li, L; Wang, SA; Jezierski, A; Moalim-Nour, L; Mohib, K; Parks, RJ; Retta, SF; Wang, LS,期刊:Stem Cells, 页码:247-257 , 文章类型: Article,,卷期:2010年28-2]
- Regulatory mechanisms pertaining to the self-renewal of stem cells remain incompletely understood. Here, we show that functional interactions between small GTPase Rap1 and the adhesion molecule E-cadherin uniquely regula...
- Human CMP-N-Acetylneuraminic Acid Hydroxylase Is a Novel Stem Cell Marker Linked to Stem Cell-Specific Mechanisms
[作者:Nystedt, J; Anderson, H; Hirvonen, T; Impola, U; Jaatinen, T; Heiskanen, A; Blomqvist, M; Satomaa, T; Natunen, J; Saarinen, J; Lehenkari, P; Valmu, L; Laine, J,期刊:Stem Cells, 页码:258-267 , 文章类型: Article,,卷期:2010年28-2]
- Human stem cells contain substantial amounts of the xenoantigen N-glycolylneuraminic acid (Neu5Gc), although the levels of Neu5Gc are low or undetectable in human body fluids and most other human tissues. The lack of Neu...
- Disruption of Bis Leads to the Deterioration of the Vascular Niche for Hematopoietic Stem Cells
[作者:Kwon, KR; Ahn, JY; Kim, MS; Jung, JY; Lee, JH; Oh, IH,期刊:Stem Cells, 页码:268-278 , 文章类型: Article,,卷期:2010年28-2]
- The stem cell niche plays an important role in the micro-environmental regulation of hematopoietic stem cells, but the integration of niche activity remains poorly understood. In this study, we show that a functional def...
- The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells
[作者:Hu, QK; Zhang, LR; Wen, JH; Wang, SL; Li, MY; Feng, RP; Yang, XL; Li, LS,期刊:Stem Cells, 页码:279-286 , 文章类型: Article,,卷期:2010年28-2]
- The transcriptional factor Sox2 and epidermal growth factor receptor (Egfr)-mediated signaling are both required for self-renewal of neural precursor cells (NPCs). However, the mechanism by which these factors coordinate...
- beta-Catenin Signaling Increases in Proliferating NG2+Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain
[作者:White, BD; Nathe, RJ; Maris, DO; Nguyen, NK; Goodson, JM; Moon, RT; Horner, PJ,期刊:Stem Cells, 页码:297-307 , 文章类型: Article,,卷期:2010年28-2]
- Wnt/beta-catenin signaling can influence the proliferation and differentiation of progenitor populations in the hippocampus and subventricular zone, known germinal centers in the adult mouse brain. It is not known whethe...
- Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence
[作者:Miyata, Y; Liu, Y; Jankovic, V; Sashida, G; Lee, JM; Shieh, JH; Naoe, T; Moore, M; Nimer, SD,期刊:Stem Cells, 页码:308-317 , 文章类型: Article,,卷期:2010年28-2]
- Hematopoietic stem cells (HSCs) can remain quiescent or they can enter the cell cycle, and either self-renew or differentiate. Although cyclin C and cyclin dependent kinase (cdk3) are essential for the transition from th...
- Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses
[作者:Lee, JK; Jin, HK; Endo, S; Schuchman, EH; Carter, JE; Bae, JS,期刊:Stem Cells, 页码:329-343 , 文章类型: Article,,卷期:2010年28-2]
- Alzheimer's disease (AD) is characterized by the deposition of amyloid-beta peptide (A beta) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been ...
- Functional Remodeling of Benign Human Prostatic Tissues In Vivo by Spontaneously Immortalized Progenitor and Intermediate Cells
[作者:Jiang, M; Strand, DW; Fernandez, S; He, Y; Yi, YJ; Birbach, A; Qiu, QC; Schmid, J; Tang, DG; Hayward, SW,期刊:Stem Cells, 页码:344-356 , 文章类型: Article,,卷期:2010年28-2]
- Tissue remodeling or regeneration is believed to initiate from multipotent stem and progenitor cells. We report here the establishment of two spontaneously immortalized adult non-tumorigenic human prostate epithelial cel...
- Lnk Deletion Reinforces the Function of Bone Marrow Progenitors in Promoting Neovascularization and Astrogliosis Following Spinal Cord Injury
[作者:Kamei, N; Kwon, SM; Alev, C; Ishikawa, M; Yokoyama, A; Nakanishi, K; Yamada, K; Horii, M; Nishimura, H; Takaki, S; Kawamoto, A; Ii, M; Akimaru, H; Tanaka, N; Nishikawa, SI; Ochi, M; Asahara, T,期刊:Stem Cells, 页码:365-375 , 文章类型: Article,,卷期:2010年28-2]
- Lnk is an intracellular adaptor protein reported as a negative regulator of proliferation in c-Kit positive, Sca-1 positive, lineage marker-negative (KSL) bone marrow cells. The KSL fraction in mouse bone marrow is belie...
- NF kappa B Activation in Embryonic Endothelial Progenitor Cells Enhances Neovascularization Via PSGL-1 Mediated Recruitment: Novel Role for LL37
[作者:Pfosser, A; El-Aouni, C; Pfisterer, I; Dietz, M; Globisch, F; Stachel, G; Trenkwalder, T; Pinkenburg, O; Horstkotte, J; Hinkel, R; Sperandio, M; Hatzopoulos, AK; Boekstegers, P; Bals, R; Kupatt, C,期刊:Stem Cells, 页码:376-385 , 文章类型: Article,,卷期:2010年28-2]
- Embryonal endothelial progenitor cells (eEPCs) are capable of inducing therapeutic angiogenesis in a chronic hind limb model. However, the proportion of eEPCs recruited to the ischemic tissue appears to be a limiting ste...
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