- Maximizing Functional Photoreceptor Differentiation From Adult Human Retinal Stem Cells
[作者:Inoue, T; Coles, BLK; Dorval, K; Bremner, R; Bessho, Y; Kageyama, R; Hino, S; Matsuoka, M; Craft, CM; McInnes, RR; Tremblay, F; Prusky, GT; van der Kooy, D,期刊:Stem Cells, 页码:489-500 , 文章类型: Article,,卷期:2010年28-3]
- Retinal stem cells (RSCs) are present in the ciliary margin of the adult human eye and can give rise to all retinal cell types. Here we show that modulation of retinal transcription factor gene expression in human RSCs g...
- Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function, and Cell Survival
[作者:Lee, HS; Bae, EJ; Yi, SH; Shim, JW; Jo, AY; Kang, JS; Yoon, EH; Rhee, YH; Park, CH; Koh, HC; Kim, HJ; Choi, HS; Han, JW; Lee, YS; Kim, J; Li, JY; Brundin, P; Lee, SH,期刊:Stem Cells, 页码:501-512 , 文章类型: Article,,卷期:2010年28-3]
- Effective dopamine (DA) neuron differentiation from neural precursor cells (NPCs) is prerequisite for precursor/stem cell-based therapy of Parkinson's disease (PD). Nurr1, an orphan nuclear receptor, has been reported as...
- Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury
[作者:Morigi, M; Rota, C; Montemurro, T; Montelatici, E; Lo Cicero, V; Imberti, B; Abbate, M; Zoja, C; Cassis, P; Longaretti, L; Rebulla, P; Introna, M; Capelli, C; Benigni, A; Remuzzi, G; Lazzari, L,期刊:Stem Cells, 页码:513-522 , 文章类型: Article,,卷期:2010年28-3]
- In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunode...
- Inhibition of Aldehyde Dehydrogenase Expands Hematopoietic Stem Cells with Radioprotective Capacity
[作者:Muramoto, GG; Russell, JL; Safi, R; Salter, AB; Himburg, HA; Daher, P; Meadows, SK; Doan, P; Storms, RW; Chao, NJ; McDonnell, DP; Chute, JP,期刊:Stem Cells, 页码:523-534 , 文章类型: Article,,卷期:2010年28-3]
- Hematopoietic stem cells (HSCs) are enriched for aldehyde dehydrogenase (ALDH) activity and ALDH is a selectable marker for human HSCs. However, the function of ALDH in HSC biology is not well understood. We sought to de...
- CCAAT/Enhancer Binding Protein Beta Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary Gland
[作者:LaMarca, HL; Visbal, AP; Creighton, CJ; Liu, H; Zhang, YQ; Behbod, F; Rosen, JM,期刊:Stem Cells, 页码:535-544 , 文章类型: Article,,卷期:2010年28-3]
- The bZIP transcription factor C/EBP beta is important for mammary gland development and its expression is deregulated in human breast cancer. To determine whether C/EBPb regulates mammary stem cells (MaSCs), we employed ...
- Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward the Post-stroke Striatum
[作者:Kojima, T; Hirota, Y; Ema, M; Takahashi, S; Miyoshi, I; Okano, H; Sawamoto, K,期刊:Stem Cells, 页码:545-554 , 文章类型: Article,,卷期:2010年28-3]
- The subventricular zone (SVZ) of the adult brain contains neural stem cells that have the capacity to regenerate new neurons after various insults. Brain ischemia causes damage to brain tissue and induces neural regenera...
- Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex
[作者:Song, H; Cha, MJ; Song, BW; Kim, IK; Chang, W; Lim, S; Choi, EJ; Ham, O; Lee, SY; Chung, N; Jang, Y; Hwang, KC,期刊:Stem Cells, 页码:555-563 , 文章类型: Article,,卷期:2010年28-3]
- The integrity of transplanted mesenchymal stem cells (MSCs) for cardiac regeneration is dependent on cell-cell or cell-matrix adhesion, which is inhibited by reactive oxygen species (ROS) generated in ischemic surroundin...
- Mouse Kidney Progenitor Cells Accelerate Renal Regeneration and Prolong Survival After Ischemic Injury
[作者:Lee, PT; Lin, HH; Jiang, ST; Lu, PJ; Chou, KJ; Fang, HC; Chiou, YY; Tang, MJ,期刊:Stem Cells, 页码:573-584 , 文章类型: Article,,卷期:2010年28-3]
- Acute tubular necrosis is followed by regeneration of damaged renal tubular epithelial cells, and renal stem cells are supposed to contribute to this process. The purpose of our study is to test the hypothesis that renal...
- High-Throughput Flow Cytometry Purification of Transduced Progenitors Expressing Defined Levels of Vascular Endothelial Growth Factor Induces Controlled Angiogenesis In Vivo
[作者:Misteli, H; Wolff, T; Fuglistaler, P; Gianni-Barrera, R; Gurke, L; Heberer, M; Banfi, A,期刊:Stem Cells, 页码:611-619 , 文章类型: Article,,卷期:2010年28-3]
- Delivery of therapeutic genes by genetically modified progenitors is a powerful tool for regenerative medicine. However, many proteins remain localized within or around the expressing cell, and heterogeneous expression l...
- Development and Function of Myeloid-Derived Suppressor Cells Generated From Mouse Embryonic and Hematopoietic Stem Cells
[作者:Zhou, ZP; French, DL; Ma, G; Eisenstein, S; Chen, Y; Divino, CM; Keller, G; Chen, SH; Pan, PY,期刊:Stem Cells, 页码:620-632 , 文章类型: Article,,卷期:2010年28-3]
- Emerging evidence suggests that myeloid-derived suppressor cells (MDSCs) have great potential as a novel immune intervention modality in the fields of transplantation and autoimmune diseases. Thus far, efforts to develop...
- Validation of beta-Actin Used as Endogenous Control for Gene Expression Analysis in Mechanobiology Studies: Amendments
[作者:Kasper, G; Ode, A; Groothuis, A; Glaeser, J; Gaber, T; Wilson, CJ; Geissler, S; Duda, GN,期刊:Stem Cells, 页码:633-634 , 文章类型: Letter,,卷期:2010年28-3]
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- Identification of Vitronectin as an Extrinsic Inducer of Cancer Stem Cell Differentiation and Tumor Formation
[作者:Hurt, EM; Chan, K; Serrat, MAD; Thomas, SB; Veenstra, TD; Farrar, WL,期刊:Stem Cells, 页码:390-398 , 文章类型: Article,,卷期:2010年28-3]
There is mounting evidence that tumors are initiated by a rare subset of cells called cancer stem cells (CSCs). CSCs are generally quiescent, self-renew, form tumors at low numbers, and give rise to the heterogeneous ...
- Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation
[作者:Bergmans, BA; Shariati, SAM; Habets, RLP; Verstreken, P; Schoonjans, L; Muller, U; Dotti, CG; De Strooper, B,期刊:Stem Cells, 页码:399-406 , 文章类型: Article,,卷期:2010年28-3]
- Alzheimer's disease amyloid precursor protein (APP) has been implicated in many neurobiologic processes, but supporting evidence remains indirect. Studies are confounded by the existence of two partially redundant APP ho...
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