- Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma
[作者:Pistollato, F; Abbadi, S; Rampazzo, E; Persano, L; Della Puppa, A; Frasson, C; Sarto, E; Scienza, R; D'avella, D; Basso, G,期刊:Stem Cells, 页码:851-862 , 文章类型: Article,,卷期:2010年28-5]
- Glioblastoma multiforme (GBM) are highly proliferative tumors currently treated by surgical removal, followed by radiotherapy and chemotherapy, which are counteracted by intratumoral hypoxia. Here we exploited image guid...
- Optimal Suppression of Protein Phosphatase 2A Activity Is Critical for Maintenance of Human Embryonic Stem Cell Self-Renewal
[作者:Yoon, BS; Jun, EK; Park, G; Yoo, SJ; Moon, JH; Baik, CS; Kim, A; Kim, H; Kim, JH; Koh, GY; Lee, HT; You, S,期刊:Stem Cells, 页码:874-884 , 文章类型: Article,,卷期:2010年28-5]
- The self-renewal of embryonic stem cells involves a balance between processes governed by crosstalk between intrinsic and extrinsic factors. We hypothesized that protein serine/threonine phosphatase 2A (PP2A) may play a ...
- Engineering Cell-Permeant FLP Recombinase for Tightly Controlled Inducible and Reversible Overexpression in Embryonic Stem Cells
[作者:Patsch, C; Peitz, M; Otte, DM; Kesseler, D; Jungverdorben, J; Wunderlich, FT; Brustle, O; Zimmer, A; Edenhofer, F,期刊:Stem Cells, 页码:894-902 , 文章类型: Article,,卷期:2010年28-5]
- Combined application of DNA recombinases Cre and FLP enables tightly controlled independent and/or sequential gene regulations. However, in practice, such dual recombinase strategies are hampered by the comparably low ef...
- A New Concept Underlying Stem Cell Lineage Skewing That Explains the Detrimental Effects of Thiazolidinediones on Bone
[作者:Bruedigam, C; Eijken, M; Koedam, M; van de Peppel, J; Drabek, K; Chiba, H; van Leeuwen, JPTM,期刊:Stem Cells, 页码:916-927 , 文章类型: Article,,卷期:2010年28-5]
- Bone-marrow adipogenesis is an aging-related phenomenon and is correlated with osteoporosis. The latter is a prevalent bone disease in the elderly leading to increased fracture risk and mortality. It is widely hypothesiz...
- Mammary Epithelial Reconstitution with Gene-Modified Stem Cells Assigns Roles to Stat5 in Luminal Alveolar Cell Fate Decisions, Differentiation, Involution, and Mammary Tumor Formation
[作者:Vafaizadeh, V; Klemmt, P; Brendel, C; Weber, K; Doebele, C; Britt, K; Grez, M; Fehse, B; Desrivieres, S; Groner, B,期刊:Stem Cells, 页码:928-938 , 文章类型: Article,,卷期:2010年28-5]
- The mammary gland represents a unique model system to study gene functions in adult stem cells. Mammary stem cells (MaSCs) can regenerate a functional epithelium on transplantation into cleared fat pads. We studied the c...
- Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo
[作者:Borghese, L; Dolezalova, D; Opitz, T; Haupt, S; Leinhaas, A; Steinfarz, B; Koch, P; Edenhofer, F; Hampl, A; Brustle, O,期刊:Stem Cells, 页码:955-964 , 文章类型: Article,,卷期:2010年28-5]
- The controlled in vitro differentiation of human embryonic stem cells (hESCs) and other pluripotent stem cells provides interesting prospects for generating large numbers of human neurons for a variety of biomedical appl...
- Bone Marrow-Derived Hematopoietic Cells Undergo Myogenic Differentiation Following a Pax-7 Independent Pathway
[作者:Xynos, A; Corbella, P; Belmonte, N; Zini, R; Manfredini, R; Ferrari, G,期刊:Stem Cells, 页码:965-973 , 文章类型: Article,,卷期:2010年28-5]
- Several reports showed that hematopoietic stem cells (HSCs) participate in muscle regeneration, raising hope for their therapeutic potential for degenerative muscle diseases. However, proof that HSCs are able to reprogra...
- Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice
[作者:Hara, Y; Nomura, T; Yoshizaki, K; Frisen, J; Osumi, N,期刊:Stem Cells, 页码:974-983 , 文章类型: Article,,卷期:2010年28-5]
- Neurogenesis occurs throughout the life in the mammalian brain. The hippocampal dentate gyrus (DG) is one of the major regions of the adult neurogenesis, where neural stem/progenitor cells continuously generate new granu...
- The Lamina Propria of Adult Human Oral Mucosa Harbors a Novel Stem Cell Population
[作者:Marynka-Kalmani, K; Treves, S; Yafee, M; Rachima, H; Gafni, Y; Cohen, MA; Pitaru, S,期刊:Stem Cells, 页码:984-995 , 文章类型: Article,,卷期:2010年28-5]
- The highly regenerative capacity of the human adult oral mucosa suggests the existence of a robust stem cell (SC) population in its lamina propria (OMLP). The purpose of this study was to characterize the availability, g...
- Concise Review: Isoforms of OCT4 Contribute to the Confusing Diversity in Stem Cell Biology
[作者:Wang, X; Dai, JW,期刊:Stem Cells, 页码:885-893 , 文章类型: Review,,卷期:2010年28-5]
- The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by alternative splicing and alternative translation initiation...
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