- Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis
[作者:Beier, JI; Kaiser, JP; Guo, LP; Martinez-Maldonado, M; Arteel, GE,期刊:Archives of Biochemistry and Biophysics , 页码:19-26 , 文章类型: Article,,卷期:2011年510-1]
- PAI-1 has been shown to be both profibrotic and antifibrotic in animal models of hepatic fibrosis. Although these models have similarities to human fibrotic liver disease, no rodent model completely recapitulates the cli...
- Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation
[作者:Sorolla, MA; Rodriguez-Colman, CNMJ; Reverter-Branchat, G; Arenas, A; Tamarit, J; Ros, J; Cabiscol, E,期刊:Archives of Biochemistry and Biophysics , 页码:27-34 , 文章类型: Article,,卷期:2011年510-1]
- Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ prote...
- Elucidation of the mechanism of N-demethylation catalyzed by cytochrome P450 monooxygenase is facilitated by exploiting nitrogen-15 heavy isotope effects
[作者:Kwiecien, RA; Molinie, R; Paneth, P; Silvestre, V; Lebreton, J; Robins, RJ,期刊:Archives of Biochemistry and Biophysics , 页码:35-41 , 文章类型: Article,,卷期:2011年510-1]
- N-15 heavy isotope effects are especially useful when detail is sought pertaining to the reaction mechanism for the cleavage of a C-N bond. Their potential in assisting to describe the mechanism of N-demethylation of ter...
- The chaperone action of bovine milk alpha(S1)- and alpha(S2)-caseins and their associated form alpha(S)-casein
[作者:Treweek, TM; Thorn, DC; Price, WE; Carver, JA,期刊:Archives of Biochemistry and Biophysics , 页码:42-52 , 文章类型: Article,,卷期:2011年510-1]
- alpha(S)-Casein, the major milk protein, comprises alpha(S1)- and alpha(S2)-casein and acts as a molecular chaperone, stabilizing an array of stressed target proteins against precipitation. Here, we report that alpha(S)-...
- Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization
[作者:Ikuta, T; Thatte, HS; Tang, JX; Mukerji, I; Knee, K; Bridges, KR; Wang, S; Montero-Huerta, P; Joshi, RM; Head, CA,期刊:Archives of Biochemistry and Biophysics , 页码:53-61 , 文章类型: Article,,卷期:2011年510-1]
- We previously demonstrated that inhaling nitric oxide (NO) increases the oxygen affinity of sickle red blood cells (RBCs) in patients with sickle cell disease (SCD). Our recent studies found that NO lowered the P-50 valu...
- The crystal structure of rice (Oryza sativa L.) Os4BGlu12, an oligosaccharide and tuberonic acid glucoside-hydrolyzing beta-glucosidase with significant thioglucohydrolase activity
[作者:Sansenya, S; Opassiri, R; Kuaprasert, B; Chen, CJ; Cairns, JRK,期刊:Archives of Biochemistry and Biophysics , 页码:62-72 , 文章类型: Article,,卷期:2011年510-1]
- Rice Os4BGlu12, a glycoside hydrolase family 1 (GH1) beta-glucosidase, hydrolyzes beta-(1,4)-linked oligosaccharides of 3-6 glucosyl residues and the beta-(1,3)-linked disaccharide laminaribiose, as well as certain glyco...
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