- AMPK activation enhances PPAR alpha activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
[作者:Meng, RS; Pei, ZH; Zhang, AX; Zhou, YT; Cai, XM; Chen, BL; Liu, GJ; Mai, WY; Wei, JR; Dong, YG,期刊:Archives of Biochemistry and Biophysics , 页码:1-7 , 文章类型: Article,,卷期:2011年511-1-2]
- Activation of adenosine monophosphate-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy through peroxisome proliferators-activated receptor-alpha (PPAR alpha) signaling pathway, but the detail...
- A novel mechanical loading model for studying the distributions of strain and mechano-growth factor expression
[作者:Peng, Q; Wang, YL; Qiu, JH; Zhang, BB; Sun, JX; Lv, YG; Yang, L,期刊:Archives of Biochemistry and Biophysics , 页码:8-13 , 文章类型: Article,,卷期:2011年511-1-2]
- Mechano-growth factor (MGF), an insulin-like growth factor-I (IGF-I) splice variant, often serves as an important local tissue repair factor in response to the mechanical environment. However, there is no model for exhib...
- Transcriptional regulation of the human neutral ceramidase gene
[作者:O'Neill, SM; Yun, JK; Fox, TE; Kester, M,期刊:Archives of Biochemistry and Biophysics , 页码:21-30 , 文章类型: Article,,卷期:2011年511-1-2]
- Ceramidases play a critical role in generating sphingosine-l-phosphate by hydrolyzing ceramide into sphingosine, a substrate for sphingosine kinase. In order to elucidate its transcriptional regulation, we identify here ...
- Modulation of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase activity and oxidative modification during the development of adjuvant arthritis
[作者:Strosova, MK; Karlovska, J; Zizkova, P; Kwolek-Mirek, M; Ponist, S; Spickett, CM; Horakova, L,期刊:Archives of Biochemistry and Biophysics , 页码:40-47 , 文章类型: Article,,卷期:2011年511-1-2]
- Adjuvant arthritis (AA) was induced by intradermal administration of Mycobacterium butyricum to the tail of Lewis rats. In sarcoplasmic reticulum (SR) of skeletal muscles, we investigated the development of AA. SR Ca2+-A...
- The kinetic mechanism for cytochrome P450 metabolism of Type II binding compounds: Evidence supporting direct reduction
[作者:Pearson, J; Dahal, UP; Rock, D; Peng, CC; Schenk, JO; Joswig-Jones, C; Jones, JP,期刊:Archives of Biochemistry and Biophysics , 页码:69-79 , 文章类型: Article,,卷期:2011年511-1-2]
- The metabolic stability of a drug is an important property that should be optimized during drug design and development. Nitrogen incorporation is hypothesized to increase the stability by coordination of nitrogen to the ...
- Co(II)-substituted Haemophilus influenzae beta-carbonic anhydrase: Spectral evidence for allosteric regulation by pH and bicarbonate ion
[作者:Hoffmann, KM; Samardzic, D; van den Heever, K; Rowlett, RS,期刊:Archives of Biochemistry and Biophysics , 页码:80-87 , 文章类型: Article,,卷期:2011年511-1-2]
- Cobalt(II)-substituted Haemophilus influenzae beta-carbonic anhydrase (HICA) has been produced by overexpression in minimal media supplemented with CoCl2, enabling kinetic, structural, and spectroscopic characterization....
- Ligand chirality effects on the dynamics of human 3-phosphoglycerate kinase: Comparison between D- and L-nucleotides
[作者:Palmai, Z; Perahia, D; Lionne, C; Fidy, J; Balog, E; Chaloin, L,期刊:Archives of Biochemistry and Biophysics , 页码:88-100 , 文章类型: Article,,卷期:2011年511-1-2]
- L-nucleoside analogues are now largely used as antiviral drugs for the treatment of viral infections like HBV, HCV and HIV. However, in order to be fully active, they need to be phosphorylated by cellular or viral kinase...
- Identification of regions responsible for heparin-induced amyloidogenesis of human serum amyloid A using its fragment peptides
[作者:Egashira, M; Takase, H; Yamamoto, I; Tanaka, M; Saito, H,期刊:Archives of Biochemistry and Biophysics , 页码:101-106 , 文章类型: Article,,卷期:2011年511-1-2]
- Human serum amyloid A (SAA) is a precursor protein of amyloid fibrils. Although several studies have been performed, a detailed understanding of the molecular mechanism for SAA fibrillation remains elusive. Glycosaminogl...
- Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase
[作者:Turbeville, TD; Zhang, JS; Adams, WC; Hunter, GA; Ferreira, GC,期刊:Archives of Biochemistry and Biophysics , 页码:107-117 , 文章类型: Article,,卷期:2011年511-1-2]
- 5-Aminolevulinate synthase (ALAS) and 8-amino-7-oxononanoate synthase (AONS) are homodimeric members of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes. Previously, linking two ALAS s...
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