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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Developing Medical Countermeasures: From BioShield to BARDA [作者：Tucker, JB,期刊：Drug Development Research, 页码：224-233 , 文章类型： Article，,卷期：2009年70-4] The U.S. Congress passed the Project BioShield Act in 2004 to create market incentives for the private sector to develop medical countermeasures (MCMs) against high-priority chemical, biological, radiological, and nuclea... Maximizing the Use of Project BioShield Contracting Opportunities [作者：Pashkoff, DB; Clerici, JM,期刊：Drug Development Research, 页码：234-238 , 文章类型： Article，,卷期：2009年70-4] This article explores the often complicated relationship between agency policymakers and the contracting officers that are charged with executing agency procurements. In particular, the article explores the role of the c... Conducting Biodefense-Related Research in a Highly Regulated Academic Environment [作者：Chopra, AK; Peterson, JW,期刊：Drug Development Research, 页码：239-245 , 文章类型： Article，,卷期：2009年70-4] In this article, we discuss the impact of regulations pertaining to national security and quality control on scientific inquiry, especially as it relates to performing research in an academic setting. Specifically, the i... Toward RNA Interference-Based Therapy for Filovirus Infections [作者：Spurgers, KB; Silvestri, LS; Warfield, KL; Bavari, S,期刊：Drug Development Research, 页码：246-254 , 文章类型： Article，,卷期：2009年70-4] Ebola (EBOV) and Marburg (MARV) viruses, of the family filoviridae, cause severe hemorrhagic fever in humans and nonhuman primates (NHPs) with mortality rates of up to 90%. Infection is thought to occur through mucous me... Identification of Novel Cellular Targets for Therapeutic Intervention Against Ebola Virus Infection by siRNA Screening [作者：Kolokoltsov, AA; Saeed, MF; Freiberg, AN; Holbrook, MR; Davey, RA,期刊：Drug Development Research, 页码：255-265 , 文章类型： Article，,卷期：2009年70-4] While much progress has been made in developing drugs against a few prominent viruses such as HIV, few examples exist for emerging infectious agents. In some cases, broad spectrum anti-viral drugs, such as ribavirin, are... US Army Botulinum Neurotoxin (BoNT) Medical Therapeutics Research Program: Past Accomplishments and Future Directions [作者：Larsen, JC,期刊：Drug Development Research, 页码：266-278 , 文章类型： Article，,卷期：2009年70-4] The United States Army (USA) under the auspices of the Medical Research and Material Command (USAMRMC) and the Defense Threat Reduction Agency (DTRA) sponsored several major efforts to develop an effective medical counte... Developing Technologies in Biodefense Research: Computational Drug Design [作者：Clark, M; Meshkat, S; Talbot, G; Konteatis, Z; Ludington, J; Zou, JM; Freedman, SJ; Wiseman, JS,期刊：Drug Development Research, 页码：279-287 , 文章类型： Article，,卷期：2009年70-4] The development of small-molecule drugs to Counter the threat of bioterrorism will differ from classical drug discovery because it will be impossible to evaluate efficacy in clinical trials for many agents. This differen... Manufacturing a Rapid Biologic Response [作者：Latham, PW,期刊：Drug Development Research, 页码：288-295 , 文章类型： Article，,卷期：2009年70-4] There are two major components in making new biologic medical countermeasures available for bio-defense and pandemic response: (1) the detection/discovery of effective countermeasures, and (2) their subsequent Process De... Using a Systems Biology Approach to Dissect Parasite-Host Interactions [作者：Vaidyanathan, R; Kodukula, K,期刊：Drug Development Research, 页码：296-302 , 文章类型： Article，,卷期：2009年70-4] The reductionist approach to biology has allowed us to understand the cell at a component level. But in recent years, with the deluge of genome-derived and empirically obtained data, we must interpret biological complexi... Accelerating Botulism Therapeutic Product Development in the Department of Defense [作者：Stahl, AM; Adler, M; Millard, CB; Gilfillan, L,期刊：Drug Development Research, 页码：303-326 , 文章类型： Article，,卷期：2009年70-4] Coordinated small-molecule drug discovery research efforts for the treatment of botulism by the public sector, especially the U.S. Department of Defense (DoD) and Department of Health and Human Services (DHHS), began in ... Tools for Planning and Coordinating Development of Medical Countermeasures in the Public Sector [作者：Manger, I; Pearson, J; Winegar, R; Gilfillan, L,期刊：Drug Development Research, 页码：327-334 , 文章类型： Article，,卷期：2009年70-4] In spite of significant increases in biodefense spending in the 7 years since the 2001 anthrax attacks, the United States may not yet be fully prepared to respond effectively to many potential biothreats. The principal r... Smart Planner: Radically Accelerating R&D to Combat a Biothreat [作者：Chadwick, AT; Edwards, RA,期刊：Drug Development Research, 页码：335-348 , 文章类型： Article，,卷期：2009年70-4] Conventional R&D processes are ill-suited to biothreats and biothreat preparation because they are intended to support risk-averse decisions for patients and are designed for longer expected development times. The Smart ... Development of Medical Countermeasures for Biodefense: How Far Have We Come in Seven Years? Preface [作者：Gilfillan, L,期刊：Drug Development Research, 页码：221-223 , 文章类型： Editorial Material，,卷期：2009年70-4]