- Total synthesis of largazole and its biological evaluation.
[作者:Numajiri, Yoshitaka;Takahashi, Takashi;Takagi, Motoki;Shin-ya, Kazuo;Doi, Takayuki;,期刊:SYNLETT, 页码:2483-2486 , 文章类型: 研究论文,,卷期:2008年-16]
- A total synthesis of largazole was achieved. The optically active b-hydroxycarbonyl unit was prepd. from modified Nagao's N-acetylthiazolidinethione. A 4-methylthiazoline-thiazole amino ester was prepd. by both a step-...
- Synthesis of a xylo-puromycin analogue.
[作者:Michel, Benoit Y.;Krishnakumar, Kollappillil S.;Strazewski, Peter;,期刊:SYNLETT, 页码:2461-2464 , 文章类型: 研究论文,,卷期:2008年-16]
- N6-Bis-demethylated xylo-puromycin analog I was synthesized through 6 steps in 56% yield from adenosine, involving a Mattocks bromoacetylation, a regio- and stereoselective ribo-epoxide ring opening with NaN3, and an eff...
- A novel intramolecular palladium-mediated cyclization for the synthesis of substituted 2-(aryl- or benzylamino)-4H-1,3-benzothiazines.
[作者:Orain, David;Blumstein, Anne-Catherine;Tasdelen, Engin;Haessig, Samuel;,期刊:SYNLETT, 页码:2433-2436 , 文章类型: 研究论文,,卷期:2008年-16]
- Synthesis of 2-aryl/benzylamino-4H-1,3-benzothiazine derivs. was achieved via an unprecedented intramol. palladium cyclization for creating a sulfur-aryl bond.
- A straightforward synthesis of enantiopure 2,6-disubstituted morpholines by a regioselective O-protection/activation protocol.
[作者:Penso, Michele;Lupi, Vittoria;Albanese, Domenico;Foschi, Francesca;Landini, Dario;Tagliabue, Aaron;,期刊:SYNLETT, 页码:2451-2454 , 文章类型: 研究论文,,卷期:2008年-16]
- Enantiopure 2,6-disubstituted morpholines were synthesized through the ring opening of chiral, nonracemic oxiranes with N nucleophiles, under solid-liq. phase-transfer catalysis (SL-PTC) conditions. The b-hydroxy tosyla...
- A convenient synthesis of highly substituted 3-N,N-dialkylamino-1,2,4-triazoles.
[作者:Batchelor, David V.;Beal, David M.;Brown, T. Bruce;Ellis, David;Gordon, David W.;Johnson, Patrick S.;Mason, Helen J.;Ralph, Michael J.;Underwood, Toby J.;Wheeler, Simon;,期刊:SYNLETT, 页码:2421-2424 , 文章类型: 研究论文,,卷期:2008年-16]
- The title compds. are prepd. from S-methylisothioureas and acyl hydrazides in moderate to good yields. The reaction is characterized by relatively mild conditions and very broad functional group tolerance.
- Generation of arylcyclopenta-1,3-dienes from cyclopenteno-spiro-benzosultams: synthesis of 2-arylnorbornenes.
[作者:Modrzejewska, Helena;Wojciechowski, Krzysztof;,期刊:SYNLETT, 页码:2465-2470 , 文章类型: 研究论文,,卷期:2008年-16]
- Aza-ortho-xylylenes generated by thermal extrusion of SO2 from cyclopenteno-spiro-benzisothiazoline 2,2-dioxides undergo [1,5]-sigmatropic H shift leading to unstable arylcyclopentadienes, which can be trapped with dieno...
- An approach to benzannelated [5,6]-spiroketals.
[作者:Bray, Christopher D.;,期刊:SYNLETT, 页码:2500-2502 , 文章类型: 研究论文,,卷期:2008年-16]
- Heating a variety of 2-hydroxybenzyl acetates bearing a range of functional groups on the 4- or 5-position of the arom. ring at 100?in neat g-methylene-g-butyrolactone (1.0 M) for 20 h gives a series of benzannelated [5,...
- A stable synthetic equivalent of 2,3-dihydropyridine.
[作者:Born, Stephen;Kobayashi, Yoshihisa;,期刊:SYNLETT, 页码:2479-2482 , 文章类型: 研究论文,,卷期:2008年-16]
- A synthetic procedure for a 2,3-dihydropyridine from its stable synthetic equiv. I is introduced. The synthesis of a chiral 2,3-dihydropyridine in a high yield and the unique mechanism of the unmasking step are describe...
- Synthesis of 3-fluoro-2,5-disubstituted furans and further derivative reactions to access fluorine-containing 3,3'-bifurans and tetrasubstituted furans.
[作者:Li, Peng;Chai, Zhuo;Zhao, Gang;Zhu, Shi-Zheng;,期刊:SYNLETT, 页码:2547-2551 , 文章类型: 研究论文,,卷期:2008年-16]
- 2,5-Disubstituted 3-fluorofurans were synthesized in 42-99% yield via DBU-promoted cyclization of electron-deficient gem-difluorohomopropargyl alcs. Starting from these compds., a series of fluorinated 3,3'-bifurans and...
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