- Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal
[作者:Kaur, G; Delluc-Clavieres, A; Poon, IKH; Forwood, JK; Glover, DJ; Jans, DA,期刊:Biochemical Journal, 页码:39-46 , 文章类型: Article,,卷期:2010年430-Part 1]
- The HMG (high-mobility group)-box-containing chromatin-remodelling factor SRY (sex-determining region on the Y chromosome) plays a key role in sex determination. Its role in the nucleus is critically dependent on two NLS...
- Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation
[作者:Chouchani, ET; Hurd, TR; Nadtochiy, SM; Brookes, PS; Fearnley, IM; Lilley, KS; Smith, RAJ; Murphy, MP,期刊:Biochemical Journal, 页码:47-59 , 文章类型: Article,,卷期:2010年430-Part 1]
- The S-nitrosation of mitochondrial proteins as a consequence of NO metabolism is of physiological and pathological significance. We previously developed a MitoSNO (mitochondria-targeted S-nitrosothiol) that selectively S...
- Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)
[作者:Kveiborg, M; Jacobsen, J; Lee, MH; Nagase, H; Wewer, UM; Murphy, G,期刊:Biochemical Journal, 页码:79-86 , 文章类型: Article,,卷期:2010年430-Part 1]
- The disintegrin and metalloprotease ADAM 12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how ADAM 12 confers its pro-tumorigenic effect; however, its proteoly...
- Modulation of mammary cancer cell migration by 15-deoxy-Delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy
[作者:Diers, AR; Dranka, BP; Ricart, KC; Oh, JY; Johnson, MS; Zhou, F; Pallero, MA; Bodenstine, TM; Murphy-Ullrich, JE; Welch, DR; Landar, A,期刊:Biochemical Journal, 页码:69-78 , 文章类型: Article,,卷期:2010年430-Part 1]
- Recently, a number of steps in the progression of metastatic disease have been shown to be regulated by redox signalling. Electrophilic lipids affect redox signalling through the post-translational modification of critic...
- One-carbon metabolism in plants: characterization of a plastid serine hydroxymethyltransferase
[作者:Zhang, Y; Sun, KH; Sandoval, FJ; Santiago, K; Roje, S,期刊:Biochemical Journal, 页码:97-105 , 文章类型: Article,,卷期:2010年430-Part 1]
- SHMT (serine hydroxymethyltransferase; EC 2.1.2.1) catalyses reversible hydroxymethyl group transfer from serine to H(4)PteGlu(n) (tetrahydrofolate), yielding glycine and 5,10-methylenetetrahydrofolate. In plastids, SHMT...
- Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface
[作者:Stirnberg, M; Maurer, E; Horstmeyer, A; Kolp, S; Frank, S; Bald, T; Arenz, K; Janzer, A; Prager, K; Wunderlich, P; Walter, J; Gutschow, M,期刊:Biochemical Journal, 页码:87-95 , 文章类型: Article,,卷期:2010年430-Part 1]
- Matriptase-2 is a member of the TTSPs (type 11 transmembrane serine proteases), an emerging class of cell surface proteases involved in tissue homoeostasis and several human disorders. Matriptase-2 exhibits a domain orga...
- Regulation of plasma-membrane-associated sialidase NEU3 gene by Sp1/Sp3 transcription factors
[作者:Yamaguchi, K; Koseki, K; Shiozaki, M; Shimada, Y; Wada, T; Miyagi, T,期刊:Biochemical Journal, 页码:107-117 , 文章类型: Article,,卷期:2010年430-Part 1]
- Gene expression of the human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is relatively high in brain and is modulated in response to many cellular processes, including neuronal ...
- Amino acid residues in the beta 3 strand and subsequent loop of the conserved ETS domain that mediate basic leucine zipper (bZIP) recruitment and potentially distinguish functional attributes of Ets proteins
[作者:Shimokawa, T; Nunomura, S; Enomoto, Y; Ra, C,期刊:Biochemical Journal, 页码:129-139 , 文章类型: Article,,卷期:2010年430-Part 1]
- Ets family members share a conserved DNA-binding ETS domain, and serve a variety of roles in development, differentiation and oncogenesis. Besides DNA binding, the ETS domain also participates in protein protein interact...
- A central role for polyamines in microtubule assembly in cells
[作者:Savarin, P; Barbet, A; Delga, S; Joshi, V; Hamon, L; Lefevre, J; Nakib, S; De Bandt, JP; Moinard, C; Curmi, PA; Pastre, D,期刊:Biochemical Journal, 页码:151-159 , 文章类型: Article,,卷期:2010年430-Part 1]
- Owing to preferential electrostatic adsorption of multivalent cations on highly anionic surfaces, natural multivalent polyamines and especially quadrivalent spermine can be considered as potential regulators of the compl...
- The obese healthy paradox: is inflammation the answer?
[作者:Barbarroja, N; Lopez-Pedrera, R; Mayas, MD; Garcia-Fuentes, E; Garrido-Sanchez, L; Macias-Gonzalez, M; El Bekay, R; Vidal-Puig, A; Tinahones, FJ,期刊:Biochemical Journal, 页码:141-149 , 文章类型: Article,,卷期:2010年430-Part 1]
- A paradoxical but common finding in the obesity clinic is the identification of individuals who can be considered 'inappropriately' healthy for their degree of obesity. We think that studying these obese but metabolicall...
- Essential arginine residue of the F-0-a subunit in F0F1-ATP synthase has a role to prevent the proton shortcut without c-ring rotation in the F-0 proton channel
[作者:Mitome, N; Ono, S; Sato, H; Suzuki, T; Sone, N; Yoshida, M,期刊:Biochemical Journal, 页码:171-177 , 文章类型: Article,,卷期:2010年430-Part 1]
- In F0F1 (F0F1-ATP synthase), proton translocation through F drives rotation of the oligomer ring of F-0-c subunits (c-ring) relative to F-0-a. Previous reports have indicated that a conserved arginine residue in F-0-a pl...
- The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
[作者:Lane, AE; Tan, JTM; Hawkins, CL; Heather, AK; Davies, MJ,期刊:Biochemical Journal, 页码:161-169 , 文章类型: Article,,卷期:2010年430-Part 1]
- MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by hydrogen peroxide to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid) respectively. Specificity cons...
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