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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Dimerization of piceatannol by Momordica charantia peroxidase and alpha-glucosidase inhibitory activity of the biotransformation products [作者：WAN XIANG; WANG XIAOBING; YANG MINGHUA; WANG JUNSONG; KONG LINGYI,期刊：Bioorganic & Medicinal Chemistry, 页码：5085-5092 , 文章类型： Article，,卷期：2011年19-17] Stilbenes, especially those oligomers, have great potential to be antihyperglycemic agents. In this study, eight stilbene dimers, including five new ones, were obtained by biotransformation of piceatannol using Momordica... DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells [作者：KISHTON RIGEL J; MILLER SEAN E; PERRY HEATHER; LYNCH TERA; PATEL MAYUR; GORE VINAYAK K; AKKARAJU GIRIDHAR R; VARADARAJAN SRIDHAR,期刊：Bioorganic & Medicinal Chemistry, 页码：5093-5102 , 文章类型： Article，,卷期：2011年19-17] A compound that can target cells expressing the estrogen receptor (ER), and produce predominantly 3-MeA adducts in those cells has been designed and synthesized. This compound produces mainly the 3-MeA adduct upon reacti... Synthesis, structure elucidation, determination of the lipophilicity and identification of antitumour activities in vitro of novel 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones with a low cytotoxicity towards normal human skin fibroblast cells [作者：SZTANKE KRZYSZTOF; TUZIMSKI TOMASZ; SZTANKE MALGORZATA; RZYMOWSKA JOLANTA; PASTERNAK KAZIMIERZ,期刊：Bioorganic & Medicinal Chemistry, 页码：5103-5116 , 文章类型： Article，,卷期：2011年19-17] Eleven novel 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4] triazin-4(6H)-ones (12-22) were designed and obtained from appropriate 1-aryl-2-hydrazonoimidazolidines (1-11) by condensation reaction with 2-oxo-2-fura... Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs [作者：GU SHUANGXI; HE QIUQIN; YANG SHIQIONG; MA XIAODONG; CHEN FENER; DE CLERCQ ERIK; BALZARINI JAN; PANNECOUQUE CHRISTOPHE,期刊：Bioorganic & Medicinal Chemistry, 页码：5117-5124 , 文章类型： Article，,卷期：2011年19-17] A series of 26 diarylpyrimidines, characterized by the hydroxymethyl linker between the left wing benzene ring and the central pyrimidine, were synthesized and evaluated for in vitro anti-HIV activity. Most of the compou... Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase [作者：ALEXACOU KYRAMELINDA; ZHANG YUN ZHI; PRALY JEANPIERRE; ZOGRAPHOS SPYROS E; CHRYSINA EVANGELIA D; OIKONOMAKOS NIKOS G; LEONIDAS DEMETRES D,期刊：Bioorganic & Medicinal Chemistry, 页码：5125-5136 , 文章类型： Article，,卷期：2011年19-17] Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetyla... Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase [作者：VEHAR BLAZ; HRAST MARTINA; KOVAC ANDREJA; KONC JANEZ; MARINER KATHERINE; CHOPRA IAN; ONEILL ALEX; JANEZIC DUSANKA; GOBEC STANISLAV,期刊：Bioorganic & Medicinal Chemistry, 页码：5137-5146 , 文章类型： Article，,卷期：2011年19-17] D-Alanine:D-alanine ligase (Ddl), an intracellular bacterial enzyme essential for cell wall biosynthesis, is an attractive target for development of novel antimicrobial drugs. This study focused on an extensive evaluatio... Ligand polarizability contributes to tau fibril binding affinity [作者：JENSEN JORDAN R; CISEK KATRYNA; HONSON NICOLETTE S; KURET JEFF,期刊：Bioorganic & Medicinal Chemistry, 页码：5147-5154 , 文章类型： Article，,卷期：2011年19-17] Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggregates have been report... Synthesis and antimicrobial activity of (E) stilbene derivatives [作者：ALBERT SABRINA; HORBACH RALF; DEISING HOLGER B; SIEWERT BIANKA; CSUK RENE,期刊：Bioorganic & Medicinal Chemistry, 页码：5155-5166 , 文章类型： Article，,卷期：2011年19-17] Plants use multiple defence mechanisms comprising both constitutive and inducible barriers to prevent entering of phytopathogenic micro-organisms. In many plant species one of the most efficient responses to combat attac... Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl- and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs [作者：STEGER JESSICA; MICURA RONALD,期刊：Bioorganic & Medicinal Chemistry, 页码：5167-5174 , 文章类型： Article，,卷期：2011年19-17] RNA-peptide conjugates that mimic amino acid-charged tRNAs and peptidyl-tRNAs are of high importance for structural and functional investigations of ribosomal complexes. Here, we present the synthesis of glycyl-, alanyl-... 3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis [作者：SHIRAI JUNYA; NAKAMURA MINORU; TARUI NAOKI; HASHIMOTO TADATOSHI; IKEURA YOSHINORI,期刊：Bioorganic & Medicinal Chemistry, 页码：5175-5182 , 文章类型： Article，,卷期：2011年19-17] A series of novel 3-benzhydryl-4-piperidone derivatives were identified as potent tachykinin neurokinin-1 (NK(1)) receptor antagonists. An efficient and versatile synthesis of this series was achieved with a coupling rea... Chromomycin SA analogs from a marine-derived Streptomyces sp. [作者：HU YOUCAI; ESPINDOLA ANA PAULA D M; STEWART NATHAN A; WEI SHUGUANG; POSNER BRUCE A; MACMILLAN JOHN B,期刊：Bioorganic & Medicinal Chemistry, 页码：5183-5189 , 文章类型： Article，,卷期：2011年19-17] Two chromomycin SA analogs, chromomycin SA(3) and chromomycin SA(2), along with deacetylchromomycin A(3) and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structure... Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine [作者：JIA MEIRONG; YANG KANGHUI; FANG HAO; XU YINGYING; SUN SIWEI; SU LI; XU WENFANG,期刊：Bioorganic & Medicinal Chemistry, 页码：5190-5198 , 文章类型： Article，,卷期：2011年19-17] Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercial... Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives [作者：DEVAKARAM RUTH; BLACK DAVID STC; ANDREWS KATHERINE T; FISHER GILLIAN M; DAVIS ROHAN A; KUMAR NARESH,期刊：Bioorganic & Medicinal Chemistry, 页码：5199-5206 , 文章类型： Article，,卷期：2011年19-17] 7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b] benzopyran ring system present in the natural product, dependensin. Dep... Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors [作者：ICHIKAWA MASANORI; YOKOMIZO AKI; ITOH MASAO; HAGINOYA NORIYASU; SUGITA KAZUYUKI; USUI HIROYUKI; TERAYAMA KOJI; KANDA AKIRA,期刊：Bioorganic & Medicinal Chemistry, 页码：5207-5224 , 文章类型： Article，,卷期：2011年19-17] We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC(50) = 0.85 nM). However, it was composed of a... Tylosema esculentum extractives and their bioactivity [作者：MAZIMBA OFENTSE; MAJINDA RUNNER R T; MODIBEDI CECILIAH; MASESANE ISHMAEL B; CENCIC AVRELIJA; CHINGWARU WALTER,期刊：Bioorganic & Medicinal Chemistry, 页码：5225-5230 , 文章类型： Article，,卷期：2011年19-17] The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, beta-sitosterol 6, behenic acid 7, oleic acid 8, sucro... CH/pi hydrogen bonds play a role in ligand recognition and equilibrium between active and inactive states of the beta 2 adrenergic receptor: An ab initio fragment molecular orbital (FMO) study [作者：OZAWA TOMONAGA; OKAZAKI KOSUKE; KITAURA KAZUO,期刊：Bioorganic & Medicinal Chemistry, 页码：5231-5237 , 文章类型： Article，,卷期：2011年19-17] We examined CH/pi hydrogen bonds using an ab initio fragment molecular orbital (FMO) method, combined with the CHPI program, to evaluate complexes of active (bound with agonist 1) and inactive (bound with inverse agonist...