- Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state
[作者:Leitch, HG; Blair, K; Mansfield, W; Ayetey, H; Humphreys, P; Nichols, J; Surani, MA; Smith, A,期刊:Development, 页码:2279-2287 , 文章类型: Article,,卷期:2010年137-14]
- Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen synthase kinase 3. The inhibitors suppress differenti...
- Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling
[作者:Blaine, SA; Ray, KC; Anunobi, R; Gannon, MA; Washington, MK; Means, AL,期刊:Development, 页码:2289-2296 , 文章类型: Article,,卷期:2010年137-14]
- Studies in both humans and rodents have found that insulin(+) cells appear within or near ducts of the adult pancreas, particularly following damage or disease, suggesting that these insulin(+) cells arise de novo from d...
- Proper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6
[作者:Conte, I; Marco-Ferreres, R; Beccari, L; Cisneros, E; Ruiz, JM; Tabanera, N; Bovolenta, P,期刊:Development, 页码:2307-Six6 , 文章类型: Article,,卷期:2010年137-14]
- Timely generation of distinct neural cell types in appropriate numbers is fundamental for the generation of a functional retina. In vertebrates, the transcription factor Six6 is initially expressed in multipotent retina ...
- Sm proteins specify germ cell fate by facilitating oskar mRNA localization
[作者:Gonsalvez, GB; Rajendra, TK; Wen, Y; Praveen, K; Matera, AG,期刊:Development, 页码:2341-2351 , 文章类型: Article,,卷期:2010年137-14]
- Sm and Sm-like proteins are RNA-binding factors found in all three domains of life. Eukaryotic Sm proteins play essential roles in pre-mRNA splicing, forming the cores of spliceosomal small nuclear ribonucleoproteins (sn...
- A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity
[作者:Mottola, G; Classen, AK; Gonzalez-Gaitan, M; Eaton, S; Zerial, M,期刊:Development, 页码:2353-2364 , 文章类型: Article,,卷期:2010年137-14]
- In addition to apicobasal polarization, some epithelia also display polarity within the plane of the epithelium. To what extent polarized endocytosis plays a role in the establishment and maintenance of planar cell polar...
- Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
[作者:Mokalled, MH; Johnson, A; Kim, Y; Oh, J; Olson, EN,期刊:Development, 页码:2365-2374 , 文章类型: Article,,卷期:2010年137-14]
- Numerous motile cell functions depend on signaling from the cytoskeleton to the nucleus. Myocardin-related transcription factors (MRTFs) translocate to the nucleus in response to actin polymerization and cooperate with s...
- The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans
[作者:Tian, CX; Sen, D; Shi, H; Foehr, ML; Plavskin, Y; Vatamaniuk, OK; Liu, J,期刊:Development, 页码:2375-2384 , 文章类型: Article,,卷期:2010年137-14]
- The bone morphogenetic protein ( BMP) signaling pathway regulates multiple developmental and homeostatic processes. Mutations in the pathway can cause a variety of somatic and hereditary disorders in humans. Multiple lev...
- Crooked, Coiled and Crimpled are three Ly6-like proteins required for proper localization of septate junction components
[作者:Nilton, A; Oshima, K; Zare, F; Byri, S; Nannmark, U; Nyberg, KG; Fehon, RG; Uv, AE,期刊:Development, 页码:2427-2437 , 文章类型: Article,,卷期:2010年137-14]
- Cellular junction formation is an elaborate process that is dependent on the regulated synthesis, assembly and membrane targeting of constituting components. Here, we report on three Drosophila Ly6-like proteins essentia...
- Endothelial alpha 5 and alpha v integrins cooperate in remodeling of the vasculature during development
[作者:van der Flier, A; Badu-Nkansah, K; Whittaker, CA; Crowley, D; Bronson, RT; Lacy-Hulbert, A; Hynes, RO,期刊:Development, 页码:2439-2449 , 文章类型: Article,,卷期:2010年137-14]
- Integrin cell adhesion receptors and fibronectin, one of their extracellular matrix ligands, have been demonstrated to be important for angiogenesis using functional perturbation studies and complete knockout mouse model...
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