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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis [作者：NOGUCHI AKIO; KITAMURA TAKESHI; ONAKA HIROYASU; HORINOUCHI SUEHARU; OHNISHI YASUO,期刊：NATURE CHEMICAL BIOLOGY, 页码：641-643 , 文章类型： Article，,卷期：2010年6-9] Although C-nitroso aromatic compounds have several bioactivities of medicinal interest, the biosynthetic enzymes involved in C-nitrosation have remained unknown until now. Here, we report the entire biosynthesis pathway ... Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags [作者：REXACH JESSICA E; ROGERS CLAUDE J; YU SEOKHO; TAO JIFANG; SUN YI E; HSIEHWILSON LINDA C,期刊：NATURE CHEMICAL BIOLOGY, 页码：645-651 , 文章类型： Article，,卷期：2010年6-9] Mechanistic studies of O-GlcNAc glycosylation have been limited by an inability to monitor the glycosylation stoichiometries of proteins obtained from cells. Here we describe a powerful method to visualize the O-GlcNAc-m... Replication-dependent instability at (CTG)center dot(CAG) repeat hairpins in human cells [作者：LIU GUOQI; CHEN XIAOMI; BISSLER JOHN J; SINDEN RICHARD R; LEFFAK MICHAEL,期刊：NATURE CHEMICAL BIOLOGY, 页码：652-659 , 文章类型： Article，,卷期：2010年6-9] Instability of (CTG)center dot(CAG) microsatellite trinucleotide repeat (TNR) sequences is responsible for more than a dozen neurological or neuromuscular diseases. TNR instability during DNA synthesis is thought to invo... Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery [作者：JAHNKE WOLFGANG; RONDEAU JEANMICHEL; COTESTA SIMONA; MARZINZIK ANDREAS; PELLE XAVIER; GEISER MARTIN; STRAUSS ANDRE; GOETTE MARJO; BITSCH FRANCIS; HEMMIG RENE; HENRY CHRYSTELE; LEHMANN SYLVIE; GLICKMAN J FRASER; RODDY THOMAS P; STOUT STEVEN J; GREEN JONATHAN R,期刊：NATURE CHEMICAL BIOLOGY, 页码：660-666 , 文章类型： Article，,卷期：2010年6-9] Bisphosphonates are potent inhibitors of farnesyl pyrophosphate synthase (FPPS) and are highly efficacious in the treatment of bone diseases such as osteoporosis, Paget's disease and tumor-induced osteolysis. In addition... A small-molecule inhibitor shows that pirin regulates migration of melanoma cells [作者：MIYAZAKI ISAO; SIMIZU SIRO; OKUMURA HIDEO; TAKAGI SATOSHI; OSADA HIROYUKI,期刊：NATURE CHEMICAL BIOLOGY, 页码：667-673 , 文章类型： Article，,卷期：2010年6-9] The discovery of small molecules that bind to a specific target and disrupt the function of proteins is an important step in chemical biology, especially for poorly characterized proteins. Human pirin is a nuclear protei... Zinc availability regulates exit from meiosis in maturing mammalian oocytes [作者：KIM ALISON M; VOGT STEFAN; OHALLORAN THOMAS V; WOODRUFF TERESA K,期刊：NATURE CHEMICAL BIOLOGY, 页码：674-681 , 文章类型： Article，,卷期：2010年6-9] Cellular metal ion fluxes are known in alkali and alkaline earth metals but are not well documented in transition metals. Here we describe major changes in the zinc physiology of the mammalian oocyte as it matures and in... Biotin synthesis begins by hijacking the fatty acid synthetic pathway [作者：LIN STEVEN; HANSON RYAN E; CRONAN JOHN E,期刊：NATURE CHEMICAL BIOLOGY, 页码：682-688 , 文章类型： Article，,卷期：2010年6-9] Although biotin is an essential enzyme cofactor found in all three domains of life, our knowledge of its biosynthesis remains fragmentary. Most of the carbon atoms of biotin are derived from pimelic acid, a seven-carbon ... An update on sphingosine-1-phosphate and other sphingolipid mediators (vol 6, pg 489, 2010) [作者：FYRST HENRIK; SABA JULIE D,期刊：NATURE CHEMICAL BIOLOGY, 页码：689-689 , 文章类型： Correction，,卷期：2010年6-9] Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes (vol 6, pg 630, 2010) [作者：WU YAOWEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：689-689 , 文章类型： Correction，,卷期：2010年6-9] POST-TRANSLATIONAL MODIFICATIONS A shift for the O-GlcNAc paradigm [作者：KOHLER JENNIFER J,期刊：NATURE CHEMICAL BIOLOGY, 页码：634-635 , 文章类型： News Item，,卷期：2010年6-9] METALLOENZYMES Natural product nitrosation [作者：KERSTEN ROLAND D; DORRESTEIN PIETER C,期刊：NATURE CHEMICAL BIOLOGY, 页码：636-637 , 文章类型： News Item，,卷期：2010年6-9] CHEMICAL ECOLOGY Reprogramming a termite monarchy [作者：BUSSELL JENNIFER J; VOSSHALL LESLIE B,期刊：NATURE CHEMICAL BIOLOGY, 页码：637-638 , 文章类型： News Item，,卷期：2010年6-9] SCRENING Your brain on drugs [作者：SAXE JONATHAN P,期刊：NATURE CHEMICAL BIOLOGY, 页码：639-640 , 文章类型： News Item，,卷期：2010年6-9]