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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase [作者：VETTING MATTHEW W; HEGDE SUBRAY S; BLANCHARD JOHN S,期刊：NATURE CHEMICAL BIOLOGY, 页码：797-799 , 文章类型： Article，,卷期：2010年6-11] The Mycobacterium tuberculosis enzyme Rv2275 catalyzes the formation of cyclo(L-Tyr-L-Tyr) using two molecules of Tyr-tRNA(Tyr) as substrates. The three-dimensional (3D) structure of Rv2275 was determined to 2.0-angstrom... An aminotransferase branch point connects purine catabolism to amino acid recycling [作者：RAMAZZINA ILEANA; COSTA ROBERTO; CENDRON LAURA; BERNI RODOLFO; PERACCHI ALESSIO; ZANOTTI GIUSEPPE; PERCUDANI RICCARDO,期刊：NATURE CHEMICAL BIOLOGY, 页码：801-806 , 文章类型： Article，,卷期：2010年6-11] Although amino acids are known precursors of purines, a pathway for the direct recycling of amino acids from purines has never been described at the molecular level. We provide NMR and crystallographic evidence that the ... Rational assignment of key motifs for function guides in silico enzyme identification [作者：HOEHNE MATTHIAS; SCHAETZLE SEBASTIAN; JOCHENS HELGE; ROBINS KAREN; BORNSCHEUER UWE T,期刊：NATURE CHEMICAL BIOLOGY, 页码：807-813 , 文章类型： Article，,卷期：2010年6-11] Biocatalysis has emerged as a powerful alternative to traditional chemistry, especially for asymmetric synthesis. One key requirement during process development is the discovery of a biocatalyst with an appropriate enant... Phosphate release in F-1-ATPase catalytic cycle follows ADP release [作者：WATANABE RIKIYA; IINO RYOTA; NOJI HIROYUKI,期刊：NATURE CHEMICAL BIOLOGY, 页码：814-820 , 文章类型： Article，,卷期：2010年6-11] F-1-ATPase is an ATP-driven rotary motor protein in which the gamma-subunit rotates against the catalytic stator ring. Although the reaction scheme of F-1 has mostly been revealed, the timing of inorganic phosphate (P-i)... Dynamics connect substrate recognition to catalysis in protein kinase A [作者：MASTERSON LARRY R; CHENG CECILIA; YU TAO; TONELLI MARCO; KORNEV ALEXANDR; TAYLOR SUSAN S; VEGLIA GIANLUIGI,期刊：NATURE CHEMICAL BIOLOGY, 页码：821-828 , 文章类型： Article，,卷期：2010年6-11] Atomic resolution studies of protein kinases have traditionally been carried out in the inhibitory state, limiting our current knowledge on the mechanisms of substrate recognition and catalysis. Using NMR, X-ray crystall... Small-molecule inhibition of Wnt signaling through activation of casein kinase 1 alpha [作者：THORNE CURTIS A; HANSON ALISON J; SCHNEIDER JUDSEN; TAHINCI EMILIOS; ORTON DARREN; CSELENYI CHRISTOPHER S; JERNIGAN KRISTIN K; MEYERS KELLY C; HANG BRIAN I; WATERSON ALEX G; KIM KWANGHO; MELANCON BRUCE; GHIDU VICTOR P; SULIKOWSKI GARY A; LAFLEUR BONNIE; SALIC ADRIAN; LEE LAURA A; MILLER DAVID M III; LEE ETHAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：829-836 , 文章类型： Article，,卷期：2010年6-11] Wnt/beta-catenin signaling is critically involved in metazoan development, stem cell maintenance and human disease. Using Xenopus laevis egg extract to screen for compounds that both stabilize Axin and promote beta-caten... Coupling of receptor conformation and ligand orientation determine graded activity [作者：BRUNING JOHN B; PARENT ALEXANDER A; GIL GERMAN; ZHAO MIN; NOWAK JASON; PACE MARGARET C; SMITH CAROLYN L; AFONINE PAVEL V; ADAMS PAUL D; KATZENELLENBOGEN JOHN A; NETTLES KENDALL W,期刊：NATURE CHEMICAL BIOLOGY, 页码：837-843 , 文章类型： Article，,卷期：2010年6-11] Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true: the conformational sta... The challenges of integrating multi-omic data sets [作者：PALSSON BERNHARD; ZENGLER KARSTEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：787-789 , 文章类型： Editorial Material，,卷期：2010年6-11] The capability to generate multi-omic data sets raises the issue of resource allocation for data generation versus data curation and integration. The initial experience of researchers shows that the effort required for t... A large-scale protein-function database [作者：APWEILER ROLF; ARMSTRONG RICHARD; BAIROCH AMOS; CORNISHBOWDEN ATHEL; HALLING PETER J; HOFMEYR JANHENDRIK S; KETTNER CARSTEN; LEYH THOMAS S; ROHWER JOHANN; SCHOMBURG DIETMAR; STEINBECK CHRISTOPH; TIPTON KEITH,期刊：NATURE CHEMICAL BIOLOGY, 页码：785-785 , 文章类型： Letter，,卷期：2010年6-11] PROTEIN ENGINEERING Check nature first, then evolve [作者：BOMMARIUS ANDREAS S,期刊：NATURE CHEMICAL BIOLOGY, 页码：793-794 , 文章类型： News Item，,卷期：2010年6-11] STRUCTURAL BIOLOGY Toward the ATP synthase mechanism [作者：WEBER JOACHIM,期刊：NATURE CHEMICAL BIOLOGY, 页码：794-795 , 文章类型： News Item，,卷期：2010年6-11] BIOSYNTHESIS A new (old) way of hijacking tRNA [作者：LAHOUD GEORGES; HOU YAMING,期刊：NATURE CHEMICAL BIOLOGY, 页码：795-796 , 文章类型： News Item，,卷期：2010年6-11]