- In vivo selection of tumor-targeting RNA motifs
[作者：MI JING; LIU YINGMIAO; RABBANI ZAHID N; YANG ZHONGGUANG; URBAN JOHANNES H; SULLENGER BRUCE A; CLARY BRYAN M,期刊：NATURE CHEMICAL BIOLOGY, 页码：22-24 , 文章类型： Article，,卷期：2010年6-1]
- In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to loca...
- Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
[作者：HUTT DARREN M; HERMAN DAVID; RODRIGUES ANA P C; NOEL SABRINA; PILEWSKI JOSEPH M; MATTESON JEANNE; HOCH BEN; KELLNER WENDY; KELLY JEFFERY W; SCHMIDT ANDRE; THOMAS PHILIP J; MATSUMURA YOSHIHIRO; SKACH WILLIAM R; GENTZSCH MARTINA; RIORDAN JOHN R; SORSCHER ERIC J; OKIYONEDA TSUKASA; YATES JOHN R III; LUKACS GERGELY L; FRIZZELL RAYMOND A; MANNING GERARD; GOTTESFELD JOEL M; BALCH WILLIAM E,期刊：NATURE CHEMICAL BIOLOGY, 页码：25-33 , 文章类型： Article，,卷期：2010年6-1]
- Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is an increasingly important approach for modifying the etiology of human disease. Loss-of-function diseases arise as a consequence of...
- Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase
[作者：LIEBGOTT PIERREPOL; LEROUX FANNY; BURLAT BENEDICTE; DEMENTIN SEBASTIEN; BAFFERT CAROLE; LAUTIER THOMAS; FOURMOND VINCENT; CECCALDI PIERRE; CAVAZZA CHRISTINE; MEYNIALSALLES ISABELLE; SOUCAILLE PHILIPPE; FONTECILLACAMPS JUAN CARLOS; GUIGLIARELLI BRUNO; BERTRAND PATRICK; ROUSSET MARC; LEGER CHRISTOPHE,期刊：NATURE CHEMICAL BIOLOGY, 页码：63-70 , 文章类型： Article，,卷期：2010年6-1]
- In hydrogenases and many other redox enzymes, the buried active site is connected to the solvent by a molecular channel whose structure may determine the enzyme's selectivity with respect to substrate and inhibitors. The...
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