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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Carbon metabolism-mediated myogenic differentiation [作者：BRACHA ABIGAIL L; RAMANATHAN ARVIND; HUANG SUI; INGBER DONALD E; SCHREIBER STUART L,期刊：NATURE CHEMICAL BIOLOGY, 页码：202-204 , 文章类型： Article，,卷期：2010年6-3] The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phos... Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry [作者：MILNE STEPHEN B; TALLMAN KERI A; SERWA REMIGIUSZ; ROUZER CAROL A; ARMSTRONG MICHELLE D; MARNETT LAWRENCE J; LUKEHART CHARLES M; PORTER NED A; BROWN H ALEX,期刊：NATURE CHEMICAL BIOLOGY, 页码：205-207 , 文章类型： Article，,卷期：2010年6-3] Alkyne-modified phospholipids can be unambiguously identified and differentiated from native species in complex mixtures by formation of dicobalthexacarbonyl complexes. This reaction is specific for alkynes and is unaffe... Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin [作者：SCHNEIDERPOETSCH TILMAN; JU JIANHUA; EYLER DANIEL E; DANG YONGJUN; BHAT SHRIDHAR; MERRICK WILLIAM C; GREEN RACHEL; SHEN BEN; LIU JUN O,期刊：NATURE CHEMICAL BIOLOGY, 页码：209-217 , 文章类型： Article，,卷期：2010年6-3] Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains incompletely understood. The glutarimide portion of CHX is seen in a family of structurally... The 2 '-OH group at the group II intron terminus acts as a proton shuttle [作者：ROITZSCH MICHAEL; FEDOROVA OLGA; PYLE ANNA MARIE,期刊：NATURE CHEMICAL BIOLOGY, 页码：218-224 , 文章类型： Article，,卷期：2010年6-3] Group II introns are self-splicing ribozymes that excise themselves from precursor RNAs and catalyze the joining of flanking exons. Excised introns can behave as parasitic RNA molecules: they can catalyze their own inser... Differences in prion strain conformations result from non-native interactions in a nucleus [作者：OHHASHI YUMIKO; ITO KAZUKI; TOYAMA BRANDON H; WEISSMAN JONATHAN S; TANAKA MOTOMASA,期刊：NATURE CHEMICAL BIOLOGY, 页码：225-230 , 文章类型： Article，,卷期：2010年6-3] Aggregation-prone proteins often misfold into multiple distinct amyloid conformations that dictate different physiological impacts. Although amyloid formation is triggered by a transient nucleus, the mechanism by which a... Rapid behavior-based identification of neuroactive small molecules in the zebrafish [作者：KOKEL DAVID; BRYAN JENNIFER; LAGGNER CHRISTIAN; WHITE RICK; CHEUNG CHUNG YAN J; MATEUS RITA; HEALEY DAVID; KIM SONIA; WERDICH ANDREAS A; HAGGARTY STEPHEN J; MACRAE CALUM A; SHOICHET BRIAN; PETERSON RANDALL T,期刊：NATURE CHEMICAL BIOLOGY, 页码：231-237 , 文章类型： Article，,卷期：2010年6-3] Neuroactive small molecules are indispensable tools for treating mental illnesses and dissecting nervous system function. However, it has been difficult to discover novel neuroactive drugs. Here, we describe a high-throu... Chemical phylogenetics of histone deacetylases [作者：BRADNER JAMES E; WEST NATHAN; GRACHAN MELISSA L; GREENBERG EDWARD F; HAGGARTY STEPHEN J; WARNOW TANDY; MAZITSCHEK RALPH,期刊：NATURE CHEMICAL BIOLOGY, 页码：238-243 , 文章类型： Article，,卷期：2010年6-3] The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a c... Chemical decay of an antibiotic inverts selection for resistance (vol 6, pg 105, 2010) [作者：PALMER ADAM C; ANGELINO ELAINE; KISHONY ROY,期刊：NATURE CHEMICAL BIOLOGY, 页码：244-244 , 文章类型： Correction，,卷期：2010年6-3] The p110 delta structure: mechanisms for selectivity and potency of new PI(3) K inhibitors (vol 6, pg 117, 2010) [作者：BERNDT ALEX; MILLER SIMON; WILLIAMS OLUSEGUN; LE DANIEL D; HOUSEMAN BENJAMIN T; PACOLD JOSEPH I; GORREC FABRICE; HON WAICHING; LIU YI; ROMMEL CHRISTIAN; GAILLARD PASCALE; RUECKLE THOMAS; SCHWARZ MATTHIAS K; SHOKAT KEVAN M; SHAW JEFFREY P; WILLIAMS ROGER L; REN PINGDA,期刊：NATURE CHEMICAL BIOLOGY, 页码：244-244 , 文章类型： Correction，,卷期：2010年6-3] Aminoglycoside activity observed on single pre-translocation ribosome complexes (vol 6, pg 54, 2010) [作者：FELDMAN MICHAEL B; TERRY DANIEL S; ALTMAN ROGER B; BLANCHARD SCOTT C,期刊：NATURE CHEMICAL BIOLOGY, 页码：244-244 , 文章类型： Correction，,卷期：2010年6-3] Domino access to highly substituted chromans and isochromans from carbohydrates [作者：LEIBELING MARKUS; KOESTER DENNIS C; PAWLICZEK MARTIN; SCHILD SVENIA C; WERZ DANIEL B,期刊：NATURE CHEMICAL BIOLOGY, 页码：199-201 , 文章类型： Article，,卷期：2010年6-3] Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, follow... Rethinking screening [作者：KODADEK THOMAS,期刊：NATURE CHEMICAL BIOLOGY, 页码：162-165 , 文章类型： Editorial Material，,卷期：2010年6-3] Bioactive compounds are most frequently identified via high-throughput screening campaigns. This article discusses the strengths and weaknesses of the most popular screening approaches and the utility of compounds derive... The (un)targeted cancer kinome [作者：FEDOROV OLEG; MUELLER SUSANNE; KNAPP STEFAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：166-169 , 文章类型： Editorial Material，,卷期：2010年6-3] The complexity of cancer signaling and the resulting difficulties in target selection have strongly biased kinase drug discovery towards clinically validated targets. Recently, novel kinase targets that are uncharacteriz... The art of the chemical probe [作者：FRYE STEPHEN V,期刊：NATURE CHEMICAL BIOLOGY, 页码：159-161 , 文章类型： Editorial Material，,卷期：2010年6-3] Chemical biologists frequently aim to create small-molecule probes that interact with a specific protein in vitro in order to explore the role of the protein in a broader biological context (cells or organisms), but a co... Turning enzymes ON with small molecules [作者：ZORN JULIE A; WELLS JAMES A,期刊：NATURE CHEMICAL BIOLOGY, 页码：179-188 , 文章类型： Review，,卷期：2010年6-3] Drug discovery and chemical genetic efforts typically focus on the identification and design of inhibitors or loss-of-function probes as a means to perturb enzyme function. These tools are effective in determining the ph... Garbled messages and corrupted translations [作者：SCHNEIDERPOETSCH TILMAN; USUI TAKEO; KAIDA DAISUKE; YOSHIDA MINORU,期刊：NATURE CHEMICAL BIOLOGY, 页码：189-198 , 文章类型： Review，,卷期：2010年6-3] Following transcription, genomic information begins a long journey toward translation of its nucleotide sequence into the amino acids of a protein. In eukaryotes, synthesized pre-mRNAs become processed to mature mRNAs by...