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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue [作者：MATSUZAKI MASANORI; HAYAMA TATSUYA; KASAI HARUO; ELLISDAVIES GRAHAM C R,期刊：NATURE CHEMICAL BIOLOGY, 页码：255-257 , 文章类型： Article，,卷期：2010年6-4] We have synthesized a photosensitive ( or caged) 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI) derivative of gamma-aminobutyric acid (GABA). Two-photon excitation of CDNI-GABA produced rapid activation of GABAergic curren... Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates [作者：LEE JIYONG; UDUGAMASOORIYA D GOMIKA; LIM HYUNSUK; KODADEK THOMAS,期刊：NATURE CHEMICAL BIOLOGY, 页码：258-260 , 文章类型： Article，,卷期：2010年6-4] Advances in high-throughput screening now enable the rapid discovery of bioactive small molecules, but these primary hits almost always exhibit modest potency. We report a strategy for the transformation of these hits in... Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring [作者：KROISS JOHANNES; KALTENPOTH MARTIN; SCHNEIDER BERND; SCHWINGER MARIAGABRIELE; HERTWECK CHRISTIAN; MADDULA RAVI KUMAR; STROHM ERHARD; SVATOS ALES,期刊：NATURE CHEMICAL BIOLOGY, 页码：261-263 , 文章类型： Article，,卷期：2010年6-4] Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens. We identified the molecular basis of this protective symbiosis... A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation [作者：SCHWARZ FLAVIO; HUANG WEI; LI CISHAN; SCHULZ BENJAMIN L; LIZAK CHRISTIAN; PALUMBO ALESSANDRO; NUMAO SHIN; NERI DARIO; AEBI MARKUS; WANG LAIXI,期刊：NATURE CHEMICAL BIOLOGY, 页码：264-266 , 文章类型： Article，,卷期：2010年6-4] We describe a new method for producing homogeneous eukaryotic N-glycoproteins. The method involves the engineering and functional transfer of the Campylobacter jejuni glycosylation machinery in Escherichia coli to expres... Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation [作者：CHATTERJEE CHAMPAK; MCGINTY ROBERT K; FIERZ BEAT; MUIR TOM W,期刊：NATURE CHEMICAL BIOLOGY, 页码：267-269 , 文章类型： Article，,卷期：2010年6-4] We have developed a readily accessible disulfide-directed methodology for the site-specific modification of histones by ubiquitin and ubiquitin-like proteins. The disulfide-linked analog of mono-ubiquitylated H2B stimula... Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis [作者：CHEN JUNJUN; AI YONGXING; WANG JIALIANG; HARACSKA LAJOS; ZHUANG ZHIHAO,期刊：NATURE CHEMICAL BIOLOGY, 页码：270-272 , 文章类型： Article，,卷期：2010年6-4] The rapid growth in ubiquitin biology requires facile chemical approaches for protein ubiquitylation that can overcome the common problem of low yield faced by the enzymatic reaction catalyzed by ubiquitin ligases. We re... Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy [作者：HAGEL JILLIAN M; FACCHINI PETER J,期刊：NATURE CHEMICAL BIOLOGY, 页码：273-275 , 文章类型： Article，,卷期：2010年6-4] Two previously undetected enzymes involved in morphine biosynthesis and unique among plants to opium poppy have been identified as non-heme dioxygenases, in contrast to the functionally analogous cytochrome P450s found i... Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea [作者：IKEUCHI YOSHIHO; KIMURA SATOSHI; NUMATA TOMOYUKI; NAKAMURA DAIGO; YOKOGAWA TAKASHI; OGATA TOSHIHIKO; WADA TAKESHI; SUZUKI TAKEO; SUZUKI TSUTOMU,期刊：NATURE CHEMICAL BIOLOGY, 页码：277-282 , 文章类型： Article，,卷期：2010年6-4] A modified base at the first (wobble) position of some tRNA anticodons is critical for deciphering the genetic code. In eukaryotes and eubacteria, AUA codons are decoded by tRNAs(Ile) with modified bases pseudouridine (a... Combinatorial profiling of chromatin binding modules reveals multisite discrimination [作者：GARSKE ADAM L; OLIVER SAMUEL S; WAGNER ELISE K; MUSSELMAN CATHERINE A; LEROY GARY; GARCIA BENJAMIN A; KUTATELADZE TATIANA G; DENU JOHN M,期刊：NATURE CHEMICAL BIOLOGY, 页码：283-290 , 文章类型： Article，,卷期：2010年6-4] Specific interactions between post-translational modifications (PTMs) and chromatin-binding proteins are central to the idea of a 'histone code'. Here, we used a 5,000-member, PTM-randomized, combinatorial peptide librar... A chemical and phosphoproteomic characterization of dasatinib action in lung cancer [作者：LI JIANNONG; RIX UWE; FANG BIN; BAI YUN; EDWARDS ARTHUR; COLINGE JACQUES; BENNETT KEIRYN L; GAO JINGCHUN; SONG LANXI; ESCHRICH STEVEN; SUPERTIFURGA GIULIO; KOOMEN JOHN; HAURA ERIC B,期刊：NATURE CHEMICAL BIOLOGY, 页码：291-299 , 文章类型： Article，,卷期：2010年6-4] We describe a strategy for comprehending signaling pathways that are active in lung cancer cells and that are targeted by dasatinib using chemical proteomics to identify direct interacting proteins combined with immunoaf... Robust processivity of myosin V under off-axis loads [作者：OGUCHI YUSUKE; MIKHAILENKO SERGEY V; OHKI TAKASHI; OLIVARES ADRIAN O; DE LA CRUZ ENRIQUE M; ISHIWATA SHINICHI,期刊：NATURE CHEMICAL BIOLOGY, 页码：300-305 , 文章类型： Article，,卷期：2010年6-4] The dimeric motor myosin V transports organelles along actin filament tracks over long distances in cells. Myosin V is a smart 'walker' that is able to swiftly adjust to variable 'road conditions' to continue its process... The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors (vol 6, pg 117, 2010) [作者：BERNDT ALEX; MILLER SIMON; WILLIAMS OLUSEGUN; LE DANIEL D; HOUSEMAN BENJAMIN T; PACOLD JOSEPH I; GORREC FABRICE; HON WAICHING; REN PINGDA; LIU YI; ROMMEL CHRISTIAN; GAILLARD PASCALE; RUECKLE THOMAS; SCHWARZ MATTHIAS K; SHOKAT KEVAN M; SHAW JEFFREY P; WILLIAMS ROGER L,期刊：NATURE CHEMICAL BIOLOGY, 页码：306-306 , 文章类型： Correction，,卷期：2010年6-4] Revealing the delta lady (vol 6, pg 82, 2010) [作者：WORKMAN PAUL; VAN MONTFORT ROB L M,期刊：NATURE CHEMICAL BIOLOGY, 页码：306-306 , 文章类型： Correction，,卷期：2010年6-4] An upfront investment (vol 6, pg 174, 2010) [作者：YOUNG DAMIAN W,期刊：NATURE CHEMICAL BIOLOGY, 页码：306-306 , 文章类型： Correction，,卷期：2010年6-4] Garbled messages and corrupted translations (vol 6, pg 189, 2010) [作者：SCHNEIDERPOETSCH TILMAN; USUI TAKEO; KAIDA DAISUKE; YOSHIDA MINORU,期刊：NATURE CHEMICAL BIOLOGY, 页码：306-306 , 文章类型： Correction，,卷期：2010年6-4] THE GENETIC CODE An archaeal path to literacy [作者：HENDRICKSON TAMARA L,期刊：NATURE CHEMICAL BIOLOGY, 页码：248-249 , 文章类型： News Item，,卷期：2010年6-4]