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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   A direct NMR method for the measurement of competitive kinetic isotope effects [作者：CHAN JEFFERSON; LEWIS ANDREW R; GILBERT MICHEL; KARWASKI MARIEFRANCE; BENNET ANDREW J,期刊：NATURE CHEMICAL BIOLOGY, 页码：405-407 , 文章类型： Article，,卷期：2010年6-6] We present a technique that uses C-13 NMR spectroscopy to measure kinetic isotope effects on the second-order rate constant (k(cat)/K-m) for enzyme-catalyzed reactions. Using only milligram quantities of isotopically lab... Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms [作者：KOKETSU KENTO; WATANABE KENJI; SUDA HARUNA; OGURI HIROKI; OIKAWA HIDEAKI,期刊：NATURE CHEMICAL BIOLOGY, 页码：408-410 , 文章类型： Article，,卷期：2010年6-6] Saframycin A is a potent antitumor antibiotic with a unique pentacyclic tetrahydroisoquinoline scaffold. We found that the nonribosomal peptide synthetase SfmC catalyzes a seven-step transformation of readily synthesized... Metabolic oxidation regulates embryonic stem cell differentiation [作者：YANES OSCAR; CLARK JULIE; WONG DIANA M; PATTI GARY J; SANCHEZRUIZ ANTONIO; BENTON H PAUL; TRAUGER SUNIA A; DESPONTS CAROLINE; DING SHENG; SIUZDAK GARY,期刊：NATURE CHEMICAL BIOLOGY, 页码：411-417 , 文章类型： Article，,卷期：2010年6-6] Metabolites offer an important unexplored complementary approach to understanding the pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem cells are characterized by abundant metabolites w... In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz [作者：WOODWARD ROBERT; YI WEN; LI LEI; ZHAO GUOHUI; EGUCHI HIRONOBU; SRIDHAR PERALI RAMU; GUO HONGJIE; SONG JING KATHERINE; MOTARI EDWIN; CAI LI; KELLEHER PATRICK; LIU XIANWEI; HAN WEIQING; ZHANG WENPENG; DING YAN; LI MEI; WANG PENG GEORGE,期刊：NATURE CHEMICAL BIOLOGY, 页码：418-423 , 文章类型： Article，,卷期：2010年6-6] Polysaccharides constitute a major component of bacterial cell surfaces and play critical roles in bacteria-host interactions. The biosynthesis of such molecules, however, has mainly been characterized through in vivo ge... Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis [作者：ONG DERRICK SEK TONG; MU TINGWEI; PALMER AMY E; KELLY JEFFERY W,期刊：NATURE CHEMICAL BIOLOGY, 页码：424-432 , 文章类型： Article，,卷期：2010年6-6] Altering intracellular calcium levels is known to partially restore mutant enzyme homeostasis in several lysosomal storage diseases, but why? We hypothesized that endoplasmic reticulum (ER) calcium increases enhance the ... Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids [作者：GROEGER ALISON L; CIPOLLINA CHIARA; COLE MARSHA P; WOODCOCK STEVEN R; BONACCI GUSTAVO; RUDOLPH TANJA K; RUDOLPH VOLKER; FREEMAN BRUCE A; SCHOPFER FRANCISCO J,期刊：NATURE CHEMICAL BIOLOGY, 页码：433-441 , 文章类型： Article，,卷期：2010年6-6] Electrophilic fatty acids are generated during inflammation by non-enzymatic reactions and can modulate inflammatory responses. We used a new mass spectrometry-based electrophile capture strategy to reveal the formation ... Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication [作者：CHRIST FRAUKE; VOET ARNOUT; MARCHAND ARNAUD; NICOLET STEFAN; DESIMMIE BELETE A; MARCHAND DAMIEN; BARDIOT DOROTHEE; VAN DER VEKEN NAM JOO; VAN REMOORTEL BARBARA; STRELKOV SERGEI V; DE MAEYER MARC; CHALTIN PATRICK; DEBYSER ZEGER,期刊：NATURE CHEMICAL BIOLOGY, 页码：442-448 , 文章类型： Article，,卷期：2010年6-6] Lens epithelium-derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase that promotes viral integration by tethering the preintegration complex to the chromatin. By virtue of its crucial role in the e... Small-molecule inhibition of APT1 affects Ras localization and signaling [作者：DEKKER FRANK J; ROCKS OLIVER; VARTAK NACHIKET; MENNINGER SASCHA; HEDBERG CHRISTIAN; BALAMURUGAN RENGARAJAN; WETZEL STEFAN; RENNER STEFFEN; GERAUER MARC; SCHOELERMANN BEATE; RUSCH MARION; KRAMER JOHN W; RAUH DANIEL; COATES GEOFFREY W; BRUNSVELD LUC; BASTIAENS PHILIPPE I H; WALDMANN HERBERT,期刊：NATURE CHEMICAL BIOLOGY, 页码：449-456 , 文章类型： Article，,卷期：2010年6-6] Cycles of depalmitoylation and repalmitoylation critically control the steady-state localization and function of various peripheral membrane proteins, such as Ras proto-oncogene products. Interference with acylation usin... Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis [作者：CASTORENO ADAM B; SMURNYY YEGOR; TORRES ANGELICA D; VOKES MARTHA S; JONES THOUIS R; CARPENTER ANNE E; EGGERT ULRIKE S,期刊：NATURE CHEMICAL BIOLOGY, 页码：457-463 , 文章类型： Article，,卷期：2010年6-6] We report the discovery of small molecules that target the Rho pathway, which is a central regulator of cytokinesis-the final step in cell division. We have developed a way of targeting a small molecule screen toward a s... Reprogramming bacteria to seek and destroy an herbicide [作者：SINHA JOY; REYES SAMUEL J; GALLIVAN JUSTIN P,期刊：NATURE CHEMICAL BIOLOGY, 页码：464-470 , 文章类型： Article，,卷期：2010年6-6] A major goal of synthetic biology is to reprogram cells to perform complex tasks. Here we show how a combination of in vitro and in vivo selection rapidly identifies a synthetic riboswitch that activates protein translat... Biosynthesis: Is it time to go retro? [作者：BACHMANN BRIAN O,期刊：NATURE CHEMICAL BIOLOGY, 页码：390-393 , 文章类型： Editorial Material，,卷期：2010年6-6] HIGH-CONTENT SCREENS Giving Rho(d) directions [作者：MUELLNER MARKUS K; NIJMAN SEBASTIAN M B,期刊：NATURE CHEMICAL BIOLOGY, 页码：397-398 , 文章类型： News Item，,卷期：2010年6-6] SYNTHETIC BIOLOGY Designer bacteria degrades toxin [作者：KIRBY JOHN R,期刊：NATURE CHEMICAL BIOLOGY, 页码：398-399 , 文章类型： News Item，,卷期：2010年6-6] CELL BIOLOGY Manipulating proteostasis [作者：SIFERS RICHARD N,期刊：NATURE CHEMICAL BIOLOGY, 页码：400-401 , 文章类型： News Item，,卷期：2010年6-6] LIPIDS COX-2's new role in inflammation [作者：CHEN CHU,期刊：NATURE CHEMICAL BIOLOGY, 页码：401-402 , 文章类型： News Item，,卷期：2010年6-6] POLYMERASES Glycan chain-length control [作者：WHITFIELD CHRIS,期刊：NATURE CHEMICAL BIOLOGY, 页码：403-404 , 文章类型： News Item，,卷期：2010年6-6]