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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共37条记录   Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies [作者：Ye, Y; McDevitt, MA; Guo, MZ; Zhang, W; Galm, O; Gore, SD; Karp, JE; Maciejewski, JP; Kowalski, J; Tsai, HL; Gondek, LP; Tsai, HC; Wang, XF; Hooker, C; Smith, BD; Carraway, HE; Herman, JG,期刊：Cancer research, 页码：8482-8490 , 文章类型： Article，,卷期：2009年69-21] Complete loss or deletion of the long arm of chromosome 5 is frequent in myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). The putative gene(s) deleted and responsible for the pathogenesis of these poo... ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors [作者：Ciro, M; Prosperini, E; Quarto, M; Grazini, U; Walfridsson, J; McBlane, F; Nucifero, P; Pacchiana, G; Capra, M; Christensen, J; Helin, K,期刊：Cancer research, 页码：8491-8498 , 文章类型： Article，,卷期：2009年69-21] The E2F and MY transcription factors are critical regulators of cell proliferation and contribute to the development of human cancers. Here, we report on the identification of a novel E2F target gene, ATAD2, the predicte... A Role for BRCA1 in Uterine Leiomyosarcoma [作者：Xing, D; Scangas, G; Nitta, M; He, L; Xu, X; Ioffe, YJM; Aspuria, PJ; Hedvat, CY; Anderson, ML; Oliva, E; Karlan, BY; Mohapatra, G; Orsulic, S,期刊：Cancer research, 页码：8231-8235 , 文章类型： Article，,卷期：2009年69-21] Uterine leiomyosarcoma (ULMS) is a rare gynecologic malignancy with a low survival rate. Currently, there is no effective treatment for ULMS. Infrequent occurrences of human WAS hamper the understanding of the initiation... Presence of the Carcinogen N '-Nitrosonornicotine in the Urine of Some Users of Oral Nicotine Replacement Therapy Products [作者：Stepanov, I; Carmella, SG; Briggs, A; Hertsgaard, L; Lindgren, B; Hatsukami, D; Hecht, SS,期刊：Cancer research, 页码：8236-8240 , 文章类型： Article，,卷期：2009年69-21] N'-nitrosonornicotine (NNN) is a strong carcinogen present in unburned tobacco and cigarette smoke. We here analyze data obtained in two studies, in which a biomarker of exposure to NNN-the sum of NNN and its pyridine-N-... Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-inducible Factor-1 alpha and-2 alpha in Colon Cancer [作者：Kikuchi, H; Pino, MS; Zeng, M; Shirasawa, S; Chung, DC,期刊：Cancer research, 页码：8499-8506 , 文章类型： Article，,卷期：2009年69-21] KRAS and BRAF mutations are frequently observed in human colon cancers. These mutations occur in a mutually exclusive manner, and each is associated with distinctive biological features. We showed previously that K-ras c... Tumor Growth Instability and Its Implications for Chemotherapy [作者：Castorina, P; Carco, D; Guiot, C; Deisboeck, TS,期刊：Cancer research, 页码：8507-8515 , 文章类型： Article，,卷期：2009年69-21] Optimal delivery of chemotherapy intensity is dependent on host- and tumor-specific characteristics. In this article, the chemotherapy late intensity schedule is revised to account for tumor growth instability, where a s... Host Lymphodepletion Enhances the Therapeutic Activity of an Oncolytic Vaccinia Virus Expressing 4-1BB Ligand [作者：Kim, HS; Kim-Schulze, S; Kim, DW; Kaufman, HL,期刊：Cancer research, 页码：8516-8525 , 文章类型： Article，,卷期：2009年69-21] Oncolytic viral vectors have shown promise as antitumor therapeutic agents but their effectiveness is complicated by induction of antiviral antibody responses and rapid host clearance of recombinant vectors. We developed... Evidence for Cancer Stem Cells in Human Endometrial Carcinoma [作者：Hubbard, SA; Friel, AM; Kumar, B; Zhang, L; Rueda, BR; Gargett, CE,期刊：Cancer research, 页码：8241-8248 , 文章类型： Article，,卷期：2009年69-21] Emerging evidence indicates that the highly regenerative human endometrium harbors rare populations of epithelial progenitor cells. In tumors of other regenerative epithelial tissues, rare cancer stem cells (CSC) have be... Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a miR-24/MKP-7/MAPK Network [作者：Zaidi, SK; Dowdy, CR; van Wijnen, AJ; Lian, JB; Raza, A; Stein, JL; Croce, CM; Stein, GS,期刊：Cancer research, 页码：8249-8255 , 文章类型： Article，,卷期：2009年69-21] Disruption of Runx1/AML1 subnuclear localization, either by a single amino acid substitution or by a chromosomal translocation [e.g., t(8;21)], is linked to the etiology of acute myeloid leukemia (AML). Here, we show tha... Nuclear Receptor Coregulators in Cancer Biology [作者：O'Malley, BW; Kumar, R,期刊：Cancer research, 页码：8217-8222 , 文章类型： Review，,卷期：2009年69-21] Coregulators (coactivators and corepressors) occupy the driving seat for actions of all nuclear receptors, and consequently, selective receptor modulator drugs. The potency and selectivity for subreactions of transcripti... Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer [作者：Weissman, B; Knudsen, KE,期刊：Cancer research, 页码：8223-8230 , 文章类型： Review，,卷期：2009年69-21] There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of... Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models [作者：Qian, CN; Furge, KA; Knol, J; Huang, D; Chen, JD; Dykema, KJ; Kort, EJ; Massie, A; Khoo, SK; Beldt, KV; Resau, JH; Anema, J; Kahnoski, RJ; Morreau, H; Camparo, P; Comperat, E; Sibony, M; Denoux, Y; Molinie, V; Vieillefond, A; Eng, C; Williams, BO; Teh, BT,期刊：Cancer research, 页码：8256-8264 , 文章类型： Article，,卷期：2009年69-21] Urothelial carcinoma of the renal pelvis is a deadly disease with an unclear tumorigenic mechanism. We conducted gene expression profiling on a set of human tumors of this type and identified a phosphatidylinositol 3-kin... CXC Receptor-1 Silencing Inhibits Androgen-Independent Prostate Cancer [作者：Shamaladevi, N; Lyn, DA; Escudero, DO; Lokeshwar, BL,期刊：Cancer research, 页码：8265-8274 , 文章类型： Article，,卷期：2009年69-21] The CXC receptor-1 (CXCR1) is a coreceptor for interleukin-8 (IL-8) and is expressed on both normal and tumor cells. The function of CXCR1 in prostate cancer was investigated by silencing its expression, using RNA interf... Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells [作者：Vitolo, MI; Weiss, MB; Szmacinski, M; Tahir, K; Waldman, T; Park, BH; Martin, SS; Weber, DJ; Bachman, KE,期刊：Cancer research, 页码：8275-8283 , 文章类型： Article，,卷期：2009年69-21] Many cancers, including breast cancer, harbor loss-of-function mutations in the catalytic domain of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) or have reduced PTEN expression through loss of heteroz... Role for Kruppel-Like Factor 4 in Determining the Outcome of p53 Response to DNA Damage [作者：Zhou, QB; Hong, Y; Zhan, QM; Shen, Y; Liu, ZH,期刊：Cancer research, 页码：8284-8292 , 文章类型： Article，,卷期：2009年69-21] Cells are incessantly exposed to many sources of genotoxic stress. A critical unresolved issue is how the resulting activation of the p53 tumor suppressor can lead to either cell cycle arrest or apoptosis depending on th... Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells [作者：Turk, D; Hall, MD; Chu, BF; Ludwig, JA; Fales, HM; Gottesman, MM; Szakacs, G,期刊：Cancer research, 页码：8293-8301 , 文章类型： Article，,卷期：2009年69-21] There is a great need for the development of novel chemotherapeutic agents that overcome the emergence of multidrug resistance (MDR) in cancer. We catalogued the National Cancer Institute's DTP drug repository in search ...