- Extrinsic Notch Ligand Delta-Like 1 Regulates Tip Cell Selection and Vascular Branching Morphogenesis
[作者：Napp, LC; Augustynik, M; Paesler, F; Krishnasamy, K; Woiterski, J; Limbourg, A; Bauersachs, J; Drexler, H; Le Noble, F; Limbourg, FP,期刊：Circulation Research, 页码：530-U52 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: In developing blood vessels, single endothelial cells (ECs) specialize into tip cells that sense vascular endothelial growth factor (VEGF) and contribute to vessel sprouting and branch formation. Tip cell diff...
- p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction
[作者：Le, NT; Takei, Y; Shishido, T; Woo, CH; Chang, E; Heo, KS; Lee, H; Lu, Y; Morrell, C; Oikawa, M; McClain, C; Wang, X; Tournier, C; Molina, CA; Taunton, J; Yan, C; Fujiwara, K; Patterson, C; Yang, J; Abe, J,期刊：Circulation Research, 页码：536-U84 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Cardiomyocyte apoptosis is one of the key events in the development and progression of heart failure, and a crucial role for ICER (inducible cAMP early repressor) in this process has been previously reported. ...
- Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics
[作者：Chen, TH; Hsu, JJ; Zhao, X; Guo, CY; Wong, MN; Huang, Y; Li, ZW; Garfinkel, A; Ho, CM; Tintut, Y; Demer, LL,期刊：Circulation Research, 页码：551-U117 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Left-right (LR) asymmetry is ubiquitous in animal development. Cytoskeletal chirality was recently reported to specify LR asymmetry in embryogenesis, suggesting that LR asymmetry in tissue morphogenesis is coo...
- Subcellular Structures and Function of Myocytes Impaired During Heart Failure Are Restored by Cardiac Resynchronization Therapy
[作者：Sachse, FB; Torres, NS; Savio-Galimberti, E; Aiba, T; Kass, DA; Tomaselli, GF; Bridge, JH,期刊：Circulation Research, 页码：588-U197 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Cardiac resynchronization therapy (CRT) is an established treatment for patients with chronic heart failure. However, CRT-associated structural and functional remodeling at cellular and subcellular levels is o...
- Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes A Study in Humans and Rats
[作者：Despa, S; Margulies, KB; Chen, L; Knowlton, AA; Havel, PJ; Taegtmeyer, H; Bers, DM; Despa, F,期刊：Circulation Research, 页码：598-U224 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Hyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition. Amylin amyloids are generally considered a pancreatic disorder in ...
- Mitochondria in Control of Cell Fate
[作者：Folmes, CDL; Dzeja, PP; Nelson, TJ; Terzic, A,期刊：Circulation Research, 页码：526-529 , 文章类型： Editorial Material，,卷期：2012年110-4]
- The behavior of the mitochondrial permeability transition pore has been linked to mitochondrial maturation underlying cardiomyocyte differentiation in the embryo. Mitochondrial signaling in heart development has direct i...
- Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2
[作者：Wang, XQ; Nigro, P; World, C; Fujiwara, K; Yan, C; Berk, BC,期刊：Circulation Research, 页码：560-U141 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Endothelial cells (EC) at regions exposed to disturbed flow (d-flow) are predisposed to inflammation and the subsequent development of atherosclerosis. We previously showed that thioredoxin interacting protein...
- Shortened Ca2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death
[作者：Belevych, AE; Terentyev, D; Terentyeva, R; Ho, HT; Gyorke, I; Bonilla, IM; Carnes, CA; Billman, GE; Gyorke, S,期刊：Circulation Research, 页码：569-U161 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Diastolic spontaneous Ca2+ waves (DCWs) are recognized as important contributors to triggered arrhythmias. DCWs are thought to arise when [Ca2+] in sarcoplasmic reticulum ([Ca2+](SR)) reaches a certain thresho...
- Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation
[作者：de Pater, E; Ciampricotti, M; Priller, F; Veerkamp, J; Strate, I; Smith, K; Lagendijk, AK; Schilling, TF; Herzog, W; Abdelilah-Seyfried, S; Hammerschmidt, M; Bakkers, J,期刊：Circulation Research, 页码：578-U179 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where Bmp signaling in vivo regulates myocardial differentiation has...
- FRS2 alpha-Mediated FGF Signals Suppress Premature Differentiation of Cardiac Stem Cells Through Regulating Autophagy Activity
[作者：Zhang, J; Liu, JC; Huang, YQ; Chang, JYF; Liu, LY; McKeehan, WL; Martin, JF; Wang, F,期刊：Circulation Research, 页码：E29-E39 , 文章类型： Article，,卷期：2012年110-4]
- Rationale: Although the fibroblast growth factor (FGF) signaling axis plays important roles in heart development, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. Objective: To in...
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