- Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells
[作者:Silva, G; Jeney, V; Chora, A; Larsen, R; Balla, J; Soares, MP,期刊:Journal of Biological Chemistry, 页码:29582-29595 , 文章类型: Article,,卷期:2009年284-43]
- Several pathologic conditions are associated with hemolysis, i.e. release of ferrous (Fe(II)) hemoglobin from red blood cells. Oxidation of cell-free hemoglobin produces (Fe(III)) methemoglobin. More extensive oxidation ...
- MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development
[作者:Yan, D; Dong, XD; Chen, XY; Wang, LH; Lu, CJ; Wang, J; Qu, J; Tu, LL,期刊:Journal of Biological Chemistry, 页码:29596-29604 , 文章类型: Article,,卷期:2009年284-43]
- MicroRNAs (miRNAs) are endogenous short (similar to 22) nucleotide RNAs that regulate gene function by modification of target mRNAs. miRNA-1 (miR-1) and miRNA-206 (miR-206) are highly expressed in skeletal muscle. Due to...
- Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase
[作者:Maghzal, GJ; Leck, MC; Collinson, E; Li, C; Stocker, R,期刊:Journal of Biological Chemistry, 页码:29251-29259 , 文章类型: Article,,卷期:2009年284-43]
- In mammalian cells, heme is degraded by heme oxygenase to biliverdin, which is then reduced to bilirubin by biliverdin reductase (BVR). Both bile pigments have reducing properties, and bilirubin is now generally consider...
- Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase C gamma 1 and Inhibition of Calcineurin
[作者:Hayashi, H; Campenot, RB; Vance, DE; Vance, JE,期刊:Journal of Biological Chemistry, 页码:29605-29613 , 文章类型: Article,,卷期:2009年284-43]
- Apolipoprotein E-containing lipoproteins (LpE) are generated in the central nervous system by glial cells, primarily astrocytes, and are recognized as key players in lipid metabolism and transport in the brain. We previo...
- C-terminal Elongation of Growth-blocking Peptide Enhances Its Biological Activity and Micelle Binding Affinity
[作者:Umetsu, Y; Aizawa, T; Muto, K; Yamamoto, H; Kamiya, M; Kumaki, Y; Mizuguchi, M; Demura, M; Hayakawa, Y; Kawano, K,期刊:Journal of Biological Chemistry, 页码:29625-29634 , 文章类型: Article,,卷期:2009年284-43]
- Growth-blocking peptide (GBP) is a hormone-like peptide that suppresses the growth of the host armyworm. Although the 23-amino acid GBP (1-23 GBP) is expressed in nonparasitized armyworm plasma, the parasitization by was...
- Tumor Necrosis Factor-alpha Induces RelA Degradation via Ubiquitination at Lysine 195 to Prevent Excessive Nuclear Factor-kappa B Activation
[作者:Fan, YH; Mao, RF; Zhao, YL; Yu, Y; Sun, WJ; Song, P; Shi, ZC; Zhang, DK; Yvon, E; Zhang, H; Fu, SB; Yang, JH,期刊:Journal of Biological Chemistry, 页码:29290-29297 , 文章类型: Article,,卷期:2009年284-43]
- Ubiquitination-mediated degradation of the RelA subunit of nuclear factor-kappa B (NF-kappa B) is critical for the termination of NF-kappa B activation. However, the precise mechanism for the ubiquitination of RelA is st...
- Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling
[作者:Woloszynek, JC; Kovacs, A; Ohlemiller, KK; Roberts, M; Sands, MS,期刊:Journal of Biological Chemistry, 页码:29684-29691 , 文章类型: Article,,卷期:2009年284-43]
- Lysosomal storage diseases (LSD) are metabolic disorders characterized by accumulation of undegraded material. The mucopolysaccharidoses (MPS) are LSDs defined by the storage of glycosaminoglycans. Previously, we hypothe...
|