- Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers
[作者:KIM HYOUNG RAE; KIM JAE JIN; PARK JUNG JAE; LEE SANG HYUP,期刊:Bioorganic & Medicinal Chemistry, 页码:5720-5729 , 文章类型: Article,,卷期:2012年20-19]
- We report the synthetic and mechanistic studies on a new cyclic disulfide mitomycin dimer, 7-N,7'-N'-(1 '',2 ''-dithiolanyl-3 '',5 ''-dimethylenyl) bismitomycin C (8), and a diol mitomycin dimer, 7-N, 7'-N'-(200,4 ''-dih...
- Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
[作者:HAYAKAWA ICHIRO; IKEDO AKIYUKI; CHINEN TAKUMI; USUI TAKEO; KIGOSHI HIDEO,期刊:Bioorganic & Medicinal Chemistry, 页码:5745-5756 , 文章类型: Article,,卷期:2012年20-19]
- Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O-7-modified glaziovianin A showed strong cytotoxicity against HeLa S-3 cells. Compared to g...
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