- Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production From Macrophages
[作者:Andou, A; Hisamatsu, T; Okamoto, S; Chinen, H; Kamada, N; Kobayashi, T; Hashimoto, M; Okutsu, T; Shimbo, K; Takeda, T; Matsumoto, H; Sato, A; Ohtsu, H; Suzuki, M; Hibi, T,期刊:Gastroenterology, 页码:564-574 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Elemental diet (ED) is effective for human Crohn's disease (CD). Although some of this effectiveness may be due to its low antigenic load and low fat content, the mechanisms remain unclear. We sought t...
- Endothelial Caveolin-1 Regulates Pathologic Angiogenesis in a Mouse Model of Colitis
[作者:Chidlow, JH; Greer, JJM; Anthoni, C; Bernatchez, P; Fernadez-Hernando, C; Bruce, M; Abdelbaqi, M; Shukla, D; Granger, DN; Sessa, WC; Kevil, CG,期刊:Gastroenterology, 页码:575-584 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Increased vascular density has been associated with progression of human inflammatory bowel diseases (IBDs) and animal models of colitis. Pathologic angiogenesis in chronically inflamed tissues is medi...
- VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
[作者:Scaldaferri, F; Vetrano, S; Sans, M; Arena, V; Straface, G; Stigliano, E; Repici, A; Sturm, A; Malesci, A; Panes, J; Yla-Herttuala, S; Fiocchi, C; Danese, S,期刊:Gastroenterology, 页码:585-595 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and might also have a role in inflammation and immunity. We examined whether VEGF-A signaling has a role in inflammatory bowel diseas...
- Narrow-Band Versus White-Light High Definition Television Endoscopic Imaging for Screening Colonoscopy: A Prospective Randomized Trial
[作者:Adler, A; Aschenbeck, J; Yenerim, T; Mayr, M; Aminalai, A; Drossel, R; Schroder, A; Scheel, M; Wiedenmann, B; Rosch, T,期刊:Gastroenterology, 页码:410-416 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Narrow-band imaging (NBI) has been implemented in gastrointestinal endoscopy to improve the contrast of endoluminal pathologic structures, one of the aims being to increase colonic adenoma detection. P...
- A Magnetic Resonance Spectroscopy Study of Brain Glutamate in a Model of Plasticity in Human Pharyngeal Motor Cortex
[作者:Singh, S; Mistry, S; Jefferson, S; Davies, K; Rothwell, J; Williams, S; Hamdy, S,期刊:Gastroenterology, 页码:417-424 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Coordinated delivery of peripheral and cortical stimuli (paired associative stimulation [PAS]) has been shown to induce plasticity in limb motor cortex, however, its application in pharyngeal motor cor...
- Inhibition of p38 Mitogen-Activated Protein Kinase Pathway as Prophylaxis of Postoperative Ileus in Mice
[作者:Wehner, S; Straesser, S; Vilz, TO; Pantelis, D; Sielecki, T; De la Cruz, VF; Hirner, A; Kalff, JC,期刊:Gastroenterology, 页码:619-629 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Postoperative ileus, an iatrogenic complication of abdominal surgery, is mediated by severe inflammation of the tunica muscularis. Macrophages that reside in the muscularis have important roles in init...
- Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection
[作者:Regueiro, M; Schraut, W; Baidoo, L; Kip, KE; Sepulveda, AR; Pesci, M; Harrison, J; Plevy, SE,期刊:Gastroenterology, 页码:441-450 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Crohn's disease commonly recurs after intestinal resection. We evaluated whether the administration of infliximab after resective intestinal surgery for Crohn's disease reduces postoperative recurrence...
- Risk of Cervical Abnormalities in Women With Inflammatory Bowel Disease: A Population-Based Nested Case-Control Study
[作者:Singh, H; Demers, AA; Nugent, Z; Mahmud, SM; Kliewer, EV; Bernstein, CN,期刊:Gastroenterology, 页码:451-458 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: We evaluated the risk of cervical abnormalities in women with inflammatory bowel disease (IBD) in a population-based, nested, case-control study. Methods: Cases with abnormal Papanicolaou (Pap) smears ...
- Changes in the Structure and Function of ICC Networks in ICC Hyperplasia and Gastrointestinal Stromal Tumors
[作者:Kwon, JG; Hwang, SJ; Hennig, GW; Bayguinov, Y; McCann, C; Chen, H; Rossi, F; Besmer, P; Sanders, KM; Ward, SM,期刊:Gastroenterology, 页码:630-639 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase c-kit. Approximately 90% of GISTs have gain-of-function mutations in the Kit gene, which leads to its constitutive activatio...
- High Detection Rates of Colorectal Neoplasia by Stool DNA Testing With a Novel Digital Melt Curve Assay
[作者:Zou, HZ; Taylor, WR; Harrington, JJ; Hussain, FTN; Cao, XM; Loprinzi, CL; Levine, TR; Rex, DK; Ahnen, D; Knigge, KL; Lance, P; Jiang, X; Smith, DI; Ahlquist, DA,期刊:Gastroenterology, 页码:459-470 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Current stool DNA tests identify about half of individuals with colorectal cancers and miss most individuals with advanced adenomas. We developed a digital melt curve (DMC) assay to quantify low-abunda...
- Methylation of Protocadherin 10, a Novel Tumor Suppressor, Is Associated With Poor Prognosis in Patients With Gastric Cancer
[作者:Yu, J; Cheng, YY; Tao, Q; Cheung, KF; Lam, CNY; Geng, H; Tian, LW; Wong, YP; Tong, JHM; Ying, JM; Jin, H; To, KF; Chan, FKL; Sung, JJY,期刊:Gastroenterology, 页码:640-651 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aim: By using methylation-sensitive representational difference analysis, we identified protocadherin 10 (PCDH10), a gene that encodes a protocadherin and is silenced in a tumor-specific manner. We analyzed ...
- Analysis of MUTYH Genotypes and Colorectal Phenotypes in Patients With MUTYH-Associated Polyposis
[作者:Nielsen, M; Joerink-Van de Beld, MC; Jones, N; Vogt, S; Tops, CM; Vasen, HFA; Sampson, JR; Aretz, S; Hes, FJ,期刊:Gastroenterology, 页码:471-476 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Biallelic mutations in the base excision DNA repair gene MUTYH lead to MUTYH-associated polyposis (MAP) and predisposition to colorectal cancer (CRC). Functional studies have demonstrated significant d...
- Direct Cytopathic Effects of Particular Hepatitis B Virus Genotypes in Severe Combined Immunodeficiency Transgenic With Urokinase-Type Plasminogen Activator Mouse With Human Hepatocytes
[作者:Sugiyama, M; Tanaka, Y; Kurbanov, F; Maruyama, I; Shimada, T; Takahashi, S; Shirai, T; Hino, K; Sakaida, I; Mizokami, M,期刊:Gastroenterology, 页码:652-662 , 文章类型: Article,,卷期:2009年136-2]
- Background & Aims: Little is known about the direct cytopathic effect of hepatitis B virus (HBV) and its association with particular viral genotypes or genetic mutations. We investigate HBV genotype-related differences i...
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