Peptidic natural products are commonly perceived as 'simple' molecules that are easily accessible by standard methods. This review sets out to demonstrate that the total synthesis of peptidic natural products is far from...
Heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and agrochemicals. Therefore, the design of novel protocols to construct heterocycles more efficiently is a major area of focus in organic chemi...
A copper-catalyzed electrophilic, umpolung amination strategy for the direct C-H amination of polyfluoroarenes and 1,3-azoles has been developed. The copper-based amination reaction is robust and can be easily scaled up ...
N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields fro...
Tandem transformations of nitriles into various N-heterocycles have been accomplished through the reaction of electrophiles with Blaise reaction intermediates formed in situ. The reaction of the Blaise reaction intermedi...
Vinylogous acyl nonaflates, like the corresponding triflates, are subject to nucleophile-triggered fragmentation as part of a tandem process for generating functionalized alkynes. Advantages to the use of nonaflates in l...
Cyclization-carbonylation-cyclization coupling reactions (CCC-coupling reactions) of N-propargylanilines and o-alkynylphenols catalyzed by (box)Pd(II) complexes afforded symmetrical bis(quinolin-3-yl) and bis(benzofuran-...
We report an efficient and highly diastereoselective oxy-Cope/ene/Claisen reaction for the synthesis of decalin frameworks possessing four contiguous stereogenic centers. A detailed mechanistic investigation and its appl...
An efficient general strategy was developed for the synthesis of previously unknown 3-C-linked glycosyl iminocoumarins. The strategy involves a copper-catalyzed multicomponent reaction of sugar-derived alkynes with tosyl...
The first phosphine-catalyzed multicomponent tandem Strecker-gamma-umpolung-addition reaction has been developed, which provides a facile access to functionalized allylic alpha-aminonitriles. The reaction is highly effic...
A novel, highly stereoselective tandem dihydroxylation, hemiketalization and conjugate addition reaction is reported that transforms a linear meso-functionalized bis-enone into a substituted singly anomeric spiroketal, e...
A new tandem cross metathesis-intramolecular aza-Michael reaction in which an alpha,alpha-difluorinated amide serves as a source of nucleophilic nitrogen is described. This process gives rise to a new family of fluorinat...
A new access to benzofulvenes bearing an indol-3-yl substituent at C-2 has been developed. Treatment of 3-propargylindoles possessing an additional hydroxy group at the other propargylic position with a cationic gold(I) ...
An approach to a variety of 3-substituted isocoumarins has been developed. The reaction proceeded from o-bromobenzamide derivatives and 1,3-diketones via CuI-catalyzed reaction in DMF under the action of K3PO4 at 120 deg...
A new strategy for the synthesis of 2-(1-hydroxyalkyl)pyrrolidines and 2-amino-1,5-diols is suggested. The target compounds can be obtained in high yields from available precursors through the intermediacy of six-membere...