- Long Circulating Nanoparticles of Etoposide Using PLGA-MPEG and PLGA-Pluronic Block Copolymers: Characterization, Drug-Release, Blood-Clearance, and Biodistribution Studies
[作者:Yadav, KS; Chuttani, K; Mishra, AK; Sawant, KK,期刊:Drug Development Research, 页码:228-239 , 文章类型: Article,,卷期:2010年71-4]
- The anti-leukemic drug, etoposide (ETO), has variable oral bioavailability ranging from 24-74% with a short terminal half-life of 1.5 h i.v. necessitating continuous infusion for 24-34 h for the treatment of leukemia. In...
- Econazole-Induced Ca2+ Fluxes and Apoptosis in Human Oral Cancer Cells
[作者:Kuo, DH; Liu, LM; Chen, HW; Chen, FA; Jan, CR,期刊:Drug Development Research, 页码:240-248 , 文章类型: Article,,卷期:2010年71-4]
- The effect of econazole on cytosolic free Ca2+ concentrations ([Ca2+](i)) and viability was explored in human oral cancer cells (OC2), using the fluorescent dyes fura-2 and WST-1, respectively. Econazole at concentration...
- Comparison of Xanthine Oxidase-Inhibiting and Free Radical-Scavenging Activities Between Plant Adaptogens of Eleutherococcus senticosus and Rhodiola rosea
[作者:Horng, CT; Liu, IM; Kuo, DH; Tsai, YW; Shieh, P,期刊:Drug Development Research, 页码:249-252 , 文章类型: Article,,卷期:2010年71-4]
- The present study employed 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical-scavenging and xanthine xanthine oxidase (XO) assays to compare the antioxidant capacity between two plant adaptogens, Eleutherococcus senticosus (A...
- Effects of a Newly Developed Tricyclic PARP-1 Inhibitor, on Ischemic Stroke
[作者:Yoo, AR; Koh, SH; Noh, MY; Cho, GW; Park, JS; Kim, Y; Lee, HC; Kim, MH; Kim, SH,期刊:Drug Development Research, 页码:253-260 , 文章类型: Article,,卷期:2010年71-4]
- Poly(ADP-ribose) polymerase (PARP)-1 plays an important role in the pathogenic mechanism of ischemic stroke. A number of studies have been undertaken to develop PARP-1 inhibitors for clinical use. We report on the newly ...
- Discriminative Stimulus Properties of Idazoxan: Mediation by Both alpha(2) Adrenoceptor Antagonism and 5-HT1A Receptor Agonism
[作者:Prus, AJ; Zornio, PA; Schuck, CJ; Heerts, T; Jacobson, SM; Winiarski, DA,期刊:Drug Development Research, 页码:261-267 , 文章类型: Article,,卷期:2010年71-4]
- Idazoxan is reference alpha(2) adrenoceptor antagonist and has been extensively used preclinically to support the "alpha(2)/D-2 receptor hypothesis" for atypical antipsychotic effects. However, previous studies have show...
- Maprotiline-Induced Ca2+ Fluxes and Apoptosis in Human Osteosarcoma Cells
[作者:Liao, WC; Huang, CC; Lu, YC; Chi, CC; Chu, ST; Su, HH; Kuo, CC; Cheng, JS; Tseng, LL; Ho, CM; Jan, CR,期刊:Drug Development Research, 页码:268-274 , 文章类型: Article,,卷期:2010年71-4]
- The effect of maprotiline on cytosolic free Ca2+ concentrations ([Ca2+](i)) and cell viability was explored in human osteosarcoma cells (MG63), using the fluorescent dyes fura-2 and WST-1, respectively. Maprotiline at co...
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