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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Experimenting with Web 2.? [作者：MARTENS ERIC,期刊：ACS CHEMICAL BIOLOGY, 页码：387-388 , 文章类型： Editorial Material，,卷期：2009年4-6] Smaller Is Better for Antibiotic Discovery [作者：WALDROP GROVER L,期刊：ACS CHEMICAL BIOLOGY, 页码：397-399 , 文章类型： Article，,卷期：2009年4-6] A recent study demonstrates the use of fragment-based drug discovery and virtual screening to develop inhibitors of biotin carboxylase that exhibit antibacterial activity. The work not only further validates biotin carbo... Comparative Assessment of Large-Scale Proteomic Studies of Apoptotic Proteolysis [作者：SIMON GABRIEL M; DIX MELISSA M; CRAVATT BENJAMIN F,期刊：ACS CHEMICAL BIOLOGY, 页码：401-408 , 文章类型： Article，,卷期：2009年4-6] Two proteomic methods were recently introduced to globally map proteolytic cleavage events in biological systems, one that characterized proteolyzed proteins by differential get migration (PROTOMAP) and the other by enzy... Illuminating the Chemistry of Life: Design, Synthesis, and Applications of "Caged" and Related Photoresponsive Compounds [作者：LEE HSIENMING; LARSON DANIEL R; LAWRENCE DAVID S,期刊：ACS CHEMICAL BIOLOGY, 页码：409-427 , 文章类型： Review，,卷期：2009年4-6] Biological systems are characterized by a level of spatial and temporal organization that often ties beyond the grasp of present day methods. Light-modulated bioreagents, including analogs of low molecular weight compoun... Substrate Specificity and Scope of MvdD, a GRASP-like Ligase from the Microviridin Biosynthetic Gene Cluster [作者：PHILMUS BENJAMIN; GUERRETTE JOSHUA P; HEMSCHEIDT THOMAS K,期刊：ACS CHEMICAL BIOLOGY, 页码：429-434 , 文章类型： Article，,卷期：2009年4-6] The cyanobacterial protease inhibitor microviridin K is ribosomally biosynthesized as a prepeptide (MvdE) and subsequently modified posttranslationally by double lactonization followed by lactamization. Two proteins belo... Alternative Inhibition of Androgen Receptor Signaling: Peptidomimetic Pyrimidines As Direct Androgen Receptor/Coactivator Disruptors [作者：GUNTHER JILLIAN R; PARENT ALEXANDER A; KATZENELLENBOGEN JOHN A,期刊：ACS CHEMICAL BIOLOGY, 页码：435-440 , 文章类型： Article，,卷期：2009年4-6] Compounds that directly disrupt the androgen receptor/steroid receptor coactivator interaction could function as novel inhibitors of androgen signaling that would remain effective in the treatment of prostate cancer that... Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells [作者：EDWARDS WESLEIGH F; YOUNG DOUGLAS D; DEITERS ALEXANDER,期刊：ACS CHEMICAL BIOLOGY, 页码：441-445 , 文章类型： Article，,卷期：2009年4-6] Cre recombinase catalyzes DNA exchange between two conserved lox recognition sites. The enzyme has extensive biological application, from basic cloning to engineering knock-out and knock-in organisms. Widespread use of C... Structure-Based Design of a Periplasmic Binding Protein Antagonist that Prevents Domain Closure [作者：BORROK M JACK; ZHU YIMIN; FOREST KATRINA T; KIESSLING LAURA L,期刊：ACS CHEMICAL BIOLOGY, 页码：447-456 , 文章类型： Article，,卷期：2009年4-6] Many receptors undergo ligand-induced conformational changes to initiate signal transduction. Periplasmic binding proteins (PBPs) are bacterial. receptors that exhibit dramatic conformational changes upon ligand binding.... Ligand Switching in Cell-Permeable Peptides: Manipulation of the alpha-Integrin Signature Motif [作者：BERNARD ELISE; PARTHASARATHI LAAVANYA; CHO MINKYU; AYLWARD KELLY; RAAB MARKUS; DAXECKER HEIDE; ODUSHLAINE COLM T; SHIELDS DENIS C; DEVOCELLE MARC; KEYES TIA; COSGRAVE LYNDA; ONEILL SARAH; MOK KENNETH H; MORAN NIAMH,期刊：ACS CHEMICAL BIOLOGY, 页码：457-471 , 文章类型： Article，,卷期：2009年4-6] A synthetic cell-permeable peptide corresponding to the highly conserved alpha-integrin signature motif, Palmityl-K(989)VGFFKR(995) (Pal-FF), induces integrin activation and aggregation in human platelets. Systematic rep... Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches [作者：MOCHALKIN IGOR; MILLER J RICHARD; NARASIMHAN LAKSHMI; THANABAL VENKATARAMAN; ERDMAN PAUL; COX PHILIP B; PRASAD J V N VARA; LIGHTLE SANDRA; HUBAND MICHAEL D; STOVER C KENDALL,期刊：ACS CHEMICAL BIOLOGY, 页码：473-483 , 文章类型： Article，,卷期：2009年4-6] As part of our effort to inhibit bacterial fatty acid biosynthesis through the recently validated target biotin carboxylase, we employed a unique combination of two emergent lead discovery strategies. We used both de nov...