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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Land of Opportunity [作者：SEEBERGER PETER H,期刊：ACS CHEMICAL BIOLOGY, 页码：589-590 , 文章类型： Editorial Material，,卷期：2009年4-8] Secondary Metabolomics: Natural Products Mass Spectrometry Goes Global [作者：KERSTEN ROLAND D; DORRESTEIN PIETER C,期刊：ACS CHEMICAL BIOLOGY, 页码：599-601 , 文章类型： Article，,卷期：2009年4-8] A global LC-MS metabolite analysis of wild-type Pseudomonas auerigunosa and mutants targeting the natural product pyochelin revealed the production of previously unknown metabolites, the 2-alkyl-4,5-dihydrothiazole-4-car... Using Small Molecules To Dissect Mechanisms of Microbial Pathogenesis [作者：PURI AARON W; BOGYO MATTHEW,期刊：ACS CHEMICAL BIOLOGY, 页码：603-616 , 文章类型： Review，,卷期：2009年4-8] Understanding the ways in which pathogens invade and neutralize their hosts is of great interest from both an academic and a clinical perspective. However, in Many cases genetic tools are unavailable,or insufficient to f... Regulation of Alkyl-dihydrothiazole-carboxylates (ATCs) by Iron and the Pyochelin Gene Cluster in Pseudomonas aeruginosa [作者：VINAYAVEKHIN NAWAPORN; SAGHATELIAN ALAN,期刊：ACS CHEMICAL BIOLOGY, 页码：617-623 , 文章类型： Article，,卷期：2009年4-8] Using the pyochelin (pch) gene cluster as an example, we demonstrate the utility of untargeted metabolomics in the discovery and characterization of secondary metabolites regulated by blosynthetic gene clusters. Comparis... Structure and Malonyl CoA-ACP Transacylase Binding of Streptomyces coelicolor Fatty Acid Synthase Acyl Carrier Protein [作者：ARTHUR CHRISTOPHER J; WILLIAMS CHRISTOPHER; POTTAGE KATHERINE; PLOSKON ELIZA; FINDLOW STUART C; BURSTON STEVEN G; SIMPSON THOMAS J; CRUMP MATTHEW P; CROSBY JOHN,期刊：ACS CHEMICAL BIOLOGY, 页码：625-636 , 文章类型： Article，,卷期：2009年4-8] Malonylation of an acyl carrier protein (ACP) by malonyl Coenzyme A-ACP transacylase (MCAT) is fundamental to bacteria( fatty acid biosynthesis. Here, we report the structure of the Steptomyces coelicolor (Sc) fatty acid... Botryllamides: Natural Product Inhibitors of ABCG2 [作者：HENRICH CURTIS J; ROBEY ROBERT W; TAKADA KENTARO; BOKESCH HEIDI R; BATES SUSAN E; SHUKLA SUNEET; AMBUDKAR SURESH V; MCMAHON JAMES B; GUSTAFSON KIRK R,期刊：ACS CHEMICAL BIOLOGY, 页码：637-647 , 文章类型： Article，,卷期：2009年4-8] ABCG2 is a membrane-localized, human transporter protein that has been demonstrated to reduce the intracellular accumulation of substrates through ATP-dependent efflux. Highly expressed in placental syncytiotrophoblasts,... A Synthetic Protein Selected for Ligand Binding Affinity Mediates ATP Hydrolysis [作者：SIMMONS CHAD R; STOMEL JOSHUA M; MCCONNELL MICHAEL D; SMITH DANIEL A; WATKINS JENNIFER L; ALLEN JAMES P; CHAPUT JOHN C,期刊：ACS CHEMICAL BIOLOGY, 页码：649-658 , 文章类型： Article，,卷期：2009年4-8] How primitive enzymes emerged from a primordial pool remains a fundamental uranswered question with Important practical implications in synthetic biology. Here we show that a de novo evolved ATP binding protein, selected... Anticonvulsant Met-Enkephalin Analogues Containing Backbone Spacers Reveal Alternative Non-Opioid Signaling in the Brain [作者：LEE HEEKYOUNG; SMITH MISTY D; SMITH BRIAN J; GRUSSENDORF JOEL; XU LIPING; GILLIES ROBERT J; WHITE H STEVE; BULAJ GRZEGORZ,期刊：ACS CHEMICAL BIOLOGY, 页码：659-671 , 文章类型： Article，,卷期：2009年4-8] Prothesis of non-critical parts of a polypeptide backbone is an attractive strategy to simplify bioactive peptides. This approach was applied to an opioid neuropeptide, Met-enkephalin, in which two adjacent Gly2-Gly3 res... Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses [作者：ASLUND ANDREAS; SIGURDSON CHRISTINA J; KLINGSTEDT THERESE; GRATHWOHL STEFAN; BOLMONT TRISTAN; DICKSTEIN DARA L; GLIMSDAL EIRIK; PROKOP STEFAN; LINDGREN MIKAEL; KONRADSSON PETER; HOLTZMAN DAVID M; HOF PATRICK R; HEPPNER FRANK L; GANDY SAMUEL; JUCKER MATHIAS; AGUZZI ADRIANO; HAMMARSTROM PER; NILSSON K PETER R,期刊：ACS CHEMICAL BIOLOGY, 页码：673-684 , 文章类型： Article，,卷期：2009年4-8] Molecular probes for selective Identification of protein aggregates are important to advance our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we report the chemical design of pentamer...