- Production of transgenic mice carrying the Thanatin gene by intratesticular injection
[作者:Miao, XY; Zhang, X,期刊:Biochemical and Biophysical Research Communications, 页码:429-433 , 文章类型: Article,,卷期:2011年415-3]
- Transgenic animals have potential applications in medicine, life sciences, and biopharmacy. In this study, we developed a convenient, economic, and efficient method for gene transfer by transfection of male spermatogonia...
- A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells
[作者:Kakeda, M; Nagata, K; Osawa, K; Matsuno, H; Hiratsuka, M; Sano, A; Okazaki, A; Shitara, S; Nishikawa, S; Masuya, A; Hata, T; Wako, S; Osaki, M; Kazuki, Y; Oshimura, M; Tomizuka, K,期刊:Biochemical and Biophysical Research Communications, 页码:439-444 , 文章类型: Article,,卷期:2011年415-3]
- The use of non-integrating human artificial chromosomes (HACs) in gene therapy possibly allows for safe and reliable genetic modification of human cells without insertional mutagenesis and/or unexpected oncogene activati...
- Disruption of HIF-1 alpha in hepatocytes impairs glucose metabolism in diet-induced obesity mice
[作者:Ochiai, D; Goda, N; Hishiki, T; Kanai, M; Senoo-Matsuda, N; Soga, T; Johnson, RS; Yoshimura, Y; Suematsu, M,期刊:Biochemical and Biophysical Research Communications, 页码:445-449 , 文章类型: Article,,卷期:2011年415-3]
- The liver plays a central role in glucose homeostasis in the whole-body by responding to environmental factors including nutrients, hormones, and oxygen. In conditions of metabolic overload such as diabetes mellitus and ...
- The size and phospholipid composition of lipid droplets can influence their proteome
[作者:Fei, WH; Zhong, L; Ta, MT; Shui, GH; Wenk, MR; Yang, HY,期刊:Biochemical and Biophysical Research Communications, 页码:455-462 , 文章类型: Article,,卷期:2011年415-3]
- The proteomic makeup of lipid droplets (LDs) is believed to regulate the function of LDs, which are now recognized as important cellular organelles that are associated with many human metabolic disorders. However, factor...
- Peroxynitrite detoxification by horse heart carboxymethylated cytochrome c is allosterically modulated by cardiolipin
[作者:Ascenzi, P; Ciaccio, C; Sinibaldi, F; Santucci, R; Coletta, M,期刊:Biochemical and Biophysical Research Communications, 页码:463-467 , 文章类型: Article,,卷期:2011年415-3]
- Carboxymethylation of equine heart cytochrome c (cytc) changes its tertiary structure by disrupting the heme-Fe-Met80 distal bond, such that carboxymethylated cytc (CM-cytc) displays myoglobin-like properties. Here, the ...
- ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum
[作者:Fulop, K; Jiang, QJ; Wetering, KVD; Pomozi, V; Szabo, PT; Aranyi, T; Sarkadi, B; Borst, P; Uitto, J; Varadi, A,期刊:Biochemical and Biophysical Research Communications, 页码:468-471 , 文章类型: Article,,卷期:2011年415-3]
- Vitamin K is a cofactor required for gamma-glutamyl carboxylation of several proteins regulating blood clotting, bone formation and soft tissue mineralization. Vitamin K3 is an important intermediate during conversion of...
- A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions
[作者:Call, SG; Brereton, D; Bullard, JT; Chung, JY; Meacham, KL; Morrell, DJ; Reeder, DJ; Schuler, JT; Slade, AD; Hansen, MDH,期刊:Biochemical and Biophysical Research Communications, 页码:485-489 , 文章类型: Article,,卷期:2011年415-3]
- Cell-cell junction remodeling is associated with dramatic actin reorganizations. Several actin regulatory systems have been implicated in actin remodeling events as cell-cell contacts are assembled and disassembled, incl...
- Impact of host responses on control of hepatitis C virus infection in Chinese blood donors
[作者:Li, TT; Chen, ZX; Zeng, JF; Zhang, JG; Wang, WJ; Zhang, L; Zheng, X; Shuai, LF; Klenerman, P; Allain, JP; Li, CY,期刊:Biochemical and Biophysical Research Communications, 页码:503-508 , 文章类型: Article,,卷期:2011年415-3]
- A study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-alpha and IFN-gamma, viral ...
- Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation
[作者:Chen, YQ; Wang, H; Yu, L; Yu, XH; Qian, YW; Cao, GQ; Wang, J,期刊:Biochemical and Biophysical Research Communications, 页码:515-518 , 文章类型: Article,,卷期:2011年415-3]
- The proprotein convertases subtilisin kexin 9 (PCSK9) binds to the epidermal growth factor domain A (EGF-A) of low-density lipoprotein receptor (LDLR) and leads to its destruction. However, the intracellular processes le...
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