- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-beta: "N1" versus "N2" TAN
[作者:Fridlender, ZG; Sun, J; Kim, S; Kapoor, V; Cheng, GJ; Ling, LN; Worthen, GS; Albelda, SM,期刊:Cancer Cell, 页码:183-194 , 文章类型: Article,,卷期:2009年16-3]
- TGF-beta blockade significantly slows tumor growth through many mechanisms, including activation of CD8(+) T cells and macrophages. Here, we show that TGF-beta blockade also increases neutrophil-attracting chemokines, re...
- 14-3-3 zeta Cooperates with ErbB2 to Promote Ductal Carcinoma In Situ Progression to Invasive Breast Cancer by Inducing Epithelial-Mesenchymal Transition
[作者:Lu, J; Guo, H; Treekitkarnmongkol, W; Li, P; Zhang, J; Shi, B; Ling, C; Zhou, XY; Chen, TZ; Chiao, PJ; Feng, X; Seewaldt, VL; Muller, WJ; Sahin, A; Hung, MC; Yu, DH,期刊:Cancer Cell, 页码:195-207 , 文章类型: Article,,卷期:2009年16-3]
- ErbB2, a metastasis-promoting oncoprotein, is overexpressed in similar to 25% of invasive/metastatic breast cancers, but in 50%-60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how a subset of Er...
- Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
[作者:Garrett, WS; Punit, S; Gallini, CA; Michaud, M; Zhang, D; Sigrist, KS; Lord, GM; Glickman, JN; Glimcher, LH,期刊:Cancer Cell, 页码:208-219 , 文章类型: Article,,卷期:2009年16-3]
- We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the innate immune system. Here, we report that the majority of T-bet(-/-) RAG2(-/-) ulcerative colitis (TRUC) mice spontaneously p...
- The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia
[作者:Klemm, L; Duy, C; Iacobucci, I; Kuchen, S; von Levetzow, G; Feldhahn, N; Henke, N; Li, ZY; Hoffmann, TK; Kim, YM; Hofmann, WK; Jumaa, H; Groffen, J; Heisterkamp, N; Martinelli, G; Lieber, MR; Casellas, R; Muschen, M,期刊:Cancer Cell, 页码:232-245 , 文章类型: Article,,卷期:2009年16-3]
- Chronic myeloid leukemia (CIVIL) is induced by BCR-ABL1 and can be effectively treated for many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 mutations and progress into fatal B lympho...
- The Tensin-3 Protein, Including its SH2 Domain, Is Phosphorylated by Src and Contributes to Tumorigenesis and Metastasis
[作者:Qian, XL; Li, GR; Vass, WC; Papageorge, A; Walker, RC; Asnaghi, L; Steinbach, PJ; Tosato, G; Hunter, K; Lowy, DR,期刊:Cancer Cell, 页码:246-258 , 文章类型: Article,,卷期:2009年16-3]
- In cell lines from advanced lung cancer, breast cancer, and melanoma, endogenous tensin-3 contributes to cell migration, anchorage-in dependent growth, and tumorigenesis. Although SH2 domains have not been reported previ...
- FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt
[作者:Pei, HD; Li, L; Fridley, BL; Jenkins, GD; Kalari, KR; Lingle, W; Petersen, G; Lou, ZK; Wang, LW,期刊:Cancer Cell, 页码:259-266 , 文章类型: Article,,卷期:2009年16-3]
- Akt is a central regulator of cell growth. Its activity can be negatively regulated by the phosphatase PHLPP that specifically dephosphorylates the hydrophobic motif of Akt (Ser473 in Aktl). However, how PHLPP is targete...
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