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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt [作者：Miao, H; Li, DQ; Mukherjee, A; Guo, H; Petty, A; Cutter, J; Basilion, JP; Sedor, J; Wu, J; Danielpour, D; Sloan, AE; Cohen, ML; Wang, BC,期刊：Cancer Cell, 页码：9-20 , 文章类型： Article，,卷期：2009年16-1] Both pro- and antioncogenic properties have been attributed to EphA2 kinase. We report that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion. W... AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer [作者：Vasudevan, KM; Barbie, DA; Davies, MA; Rabinovsky, R; McNear, CJ; Kim, JJ; Hennessy, BT; Tseng, H; Pochanard, P; Kim, SY; Dunn, IF; Schinzel, AC; Sandy, P; Hoersch, S; Sheng, Q; Gupta, PB; Boehm, JS; Reiling, JH; Silver, S; Lu, YL; Stemke-Hale, K; Dutta, B; Joy, C; Sahin, AA; Gonzalez-Angulo, AM; Lluch, A; Rameh, LE; Jacks, T; Root, DE; Lander, ES; Mills, GB; Hahn, WC; Sellers, WR; Garraway, LA,期刊：Cancer Cell, 页码：21-32 , 文章类型： Article，,卷期：2009年16-1] Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through a... Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases [作者：Wang, YYV; Leblanc, M; Wade, M; Jochemsen, AG; Wahl, GM,期刊：Cancer Cell, 页码：33-43 , 文章类型： Article，,卷期：2009年16-1] Mdmx is a critical negative regulator of the p53 pathway that is stoichiometrically limiting in some tissues. Posttranslational modification and degradation of Mdmx after DNA damage have been proposed to be essential for... Proteasomal and Genetic Inactivation of the NF1 Tumor Suppressor in Gliomagenesis [作者：McGillicuddy, LT; Fromm, JA; Hollstein, PE; Kubek, S; Beroukhim, R; De Raedt, T; Johnson, BW; Williams, SMG; Nghiemphu, P; Liau, LM; Cloughesy, TF; Mischel, PS; Parret, A; Seiler, J; Moldenhauer, G; Scheffzek, K; Stemmer-Rachamimov, AO; Sawyers, CL; Brennan, C; Messiaen, L; Mellinghoff, IK; Cichowski, K,期刊：Cancer Cell, 页码：44-54 , 文章类型： Article，,卷期：2009年16-1] Loss-of-function mutations in the NF1 tumor suppressor result in deregulated Ras signaling and drive tumorigenesis in the familial cancer syndrome neurofibromatosis type I. However, the extent to which NF1 inactivation p... Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment [作者：Demehri, S; Turkoz, A; Kopan, R,期刊：Cancer Cell, 页码：55-66 , 文章类型： Article，,卷期：2009年16-1] Notch1 is a proto-oncogene in several organs. In the skin, however, Notch 1 deletion leads to tumor formation, suggesting that Notch1 is a "tumor suppressor" within this context. Here we demonstrate that, unlike classica... Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals [作者：Zhang, XHF; Wang, QQ; Gerald, W; Hudis, CA; Norton, L; Smid, M; Foekens, JA; Massague, J,期刊：Cancer Cell, 页码：67-78 , 文章类型： Article，,卷期：2009年16-1] Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene expression signature of Src activation is associated wit...