- MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
[作者：Enge, M; Bao, W; Hedstrom, E; Jackson, SP; Moumen, A; Selivanova, G,期刊：Cancer Cell, 页码：171-183 , 文章类型： Article，,卷期：2009年15-3]
We have previously identified the p53-reactivating compound RITA in a cell-based screen. Here, using microarray analysis, we show that the global transcriptional response of tumor cells to RITA is p53 dependent. Pathw...
- Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein
[作者：Ianari, A; Natale, T; Calo, E; Ferretti, E; Alesse, E; Screpanti, I; Haigis, K; Gulino, A; Lees, JA,期刊：Cancer Cell, 页码：184-194 , 文章类型： Article，,卷期：2009年15-3]
- The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release ...
- Cancer Metastasis Is Accelerated through Immunosuppression during Snail-induced EMT of Cancer Cells
[作者：Kudo-Saito, C; Shirako, H; Takeuchi, T; Kawakami, Y,期刊：Cancer Cell, 页码：195-206 , 文章类型： Article，,卷期：2009年15-3]
- Epithelial-mesenchymal transition (EMT) is a key step toward cancer metastasis, and Snail is a major transcription factor governing EMT. Here, we demonstrate that Snail-induced EMT accelerates cancer metastasis through n...
- Oncogenic Function of ATDC in Pancreatic Cancer through Wnt Pathway Activation and beta-Catenin Stabilization
[作者：Wang, LD; Heidt, DG; Lee, CJ; Yang, H; Logsdon, CD; Zhang, LZ; Fearon, ER; Ljungman, M; Simeone, DM,期刊：Cancer Cell, 页码：207-219 , 文章类型： Article，,卷期：2009年15-3]
- Pancreatic cancer is a deadly disease characterized by late diagnosis and resistance to therapy. Much progress has been made in defining gene defects in pancreatic cancer, but a full accounting of its molecular pathogene...
- Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
[作者：Paez-Ribes, M; Allen, E; Hudock, J; Takeda, T; Okuyama, H; Vinals, F; Inoue, M; Bergers, G; Hanahan, D; Casanovas, O,期刊：Cancer Cell, 页码：220-231 , 文章类型： Article，,卷期：2009年15-3]
- Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitu...
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
[作者：Ebos, JML; Lee, CR; Cruz-Munoz, W; Bjarnason, GA; Christensen, JG; Kerbel, RS,期刊：Cancer Cell, 页码：232-239 , 文章类型： Article，,卷期：2009年15-3]
- Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving short-term therapy in various metastasis assays, including a...
- p53 and MDM2: Antagonists or Partners in Crime?
[作者：Eischen, CM; Lozano, G,期刊：Cancer Cell, 页码：161-162 , 文章类型： Editorial Material，,卷期：2009年15-3]
- Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2...
- Taking the Stress out of Melanoma
[作者：Martin, MJ; Carling, D; Marais, R,期刊：Cancer Cell, 页码：163-164 , 文章类型： Editorial Material，,卷期：2009年15-3]
- A recent study published in Molecular Cell describes a mechanism whereby oncogenic BRAF inhibits AMPK in melanoma cells. This may explain why cancer cells expressing oncogenic BRAF grow under conditions of metabolic stre...
- EpCAM: Another Surface-to-Nucleus Missile
[作者：Carpenter, G; Brewer, MR,期刊：Cancer Cell, 页码：165-166 , 文章类型： Editorial Material，,卷期：2009年15-3]
- The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of N...
- Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited
[作者：Loges, S; Mazzone, M; Hohensinner, P; Carmeliet, P,期刊：Cancer Cell, 页码：167-170 , 文章类型： Editorial Material，,卷期：2009年15-3]
- Clinical practice reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months, because tumors elicit evasive resistance. In this issue of Cancer Cell, two pap...
|