Cancer Cell————————个性化文献订阅—

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
[作者：Crawford, Y; Kasman, I; Yu, LL; Zhong, CL; Wu, XM; Modrusan, Z; Kaminker, J; Ferrara, N,期刊：Cancer Cell, 页码：21-34 , 文章类型： Article，,卷期：2009年15-1]
Tumor- or cancer-associated fibroblasts (TAFs or CAFs) from different tumors exhibit distinct angiogenic and tumorigenic properties. Unlike normal skin fibroblasts or TAFs from TIB6 tumors that are sensitive to anti-VEGF...

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche
[作者：Erier, JT; Bennewith, KL; Cox, TR; Lang, G; Bird, D; Koong, A; Le, QT; Giaccia, AJ,期刊：Cancer Cell, 页码：35-44 , 文章类型： Article，,卷期：2009年15-1]
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted b...

MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer
[作者：Hu, GH; Chong, RA; Yang, QF; Wei, Y; Blanco, MA; Li, F; Reiss, M; Au, JLS; Haffty, BG; Kang, YB,期刊：Cancer Cell, 页码：9-20 , 文章类型： Article，,卷期：2009年15-1]
Targeted therapy for metastatic diseases relies on the identification of functionally important metastasis genes from a large number of random genetic alterations. Here we use a computational algorithm to map minimal rec...

Genome-wide Loss-of-Function Screen Reveals an Important Role for the Proteasome on HDAC Inhibitor-Induced Apoptosis
[作者：Fotheringham, S; Epping, MT; Stimson, L; Khan, O; Wood, V; Pezzella, F; Bernards, R; La Thangue, NB,期刊：Cancer Cell, 页码：57-66 , 文章类型： Article，,卷期：2009年15-1]
Aberrant acetylation has been strongly linked to tumorigenesis, and the modulation of acetylation through targeting histone deacetylases (HDACs) is gathering increasing pace as a viable therapeutic strategy. A genome-...

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Models
[作者：Llaguno, SA; Chen, J; Kwon, CH; Jackson, EL; Li, YJ; Burns, DK; Alvarez-Buylla, A; Parada, LF,期刊：Cancer Cell, 页码：45-56 , 文章类型： Article，,卷期：2009年15-1]
Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin has not been rigorously determined. We previously reported mous...

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
[作者：Otto, T; Horn, S; Brockmann, M; Eilers, U; Schuttrumpf, L; Popov, N; Kenney, AM; Schulte, JH; Beijersbergen, R; Christiansen, H; Berwanger, B; Eilers, M,期刊：Cancer Cell, 页码：67-78 , 文章类型： Article，,卷期：2009年15-1]
In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene ...

Tumor-Associated Fibroblasts as "Trojan Horse" Mediators of Resistance to Anti-VEGF Therapy
[作者：Francia, G; Emmenegger, U; Kerbel, RS,期刊：Cancer Cell, 页码：3-5 , 文章类型： Editorial Material，,卷期：2009年15-1]
While targeting VEGF has shown success against a number of human cancers, drug resistance has resulted in compromised clinical benefits. In this issue of Cancer Cell, Crawford et al. (2009) report that tumors resistant t...

Unholy Matrimony: Aurora A and N-Myc as Malignant Partners Neuroblastoma
[作者：Maris, JM,期刊：Cancer Cell, 页码：5-6 , 文章类型： Editorial Material，,卷期：2009年15-1]
Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequ...

The Metastasis Problem Gets Stickier
[作者：Kwong, LN; Chin, L,期刊：Cancer Cell, 页码：1-2 , 文章类型： Editorial Material，,卷期：2009年15-1]
The enormity and complexity of cancer genome data present significant challenges in downstream validation of novel oncogenes and tumor suppressors. In this issue of Cancer Cell, Hu at al. evaluate candidate oncogenes in ...

Curing APL: Differentiation or Destruction?
[作者：Kogan, SC,期刊：Cancer Cell, 页码：7-8 , 文章类型： Editorial Material，,卷期：2009年15-1]
In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia is independent of their ability to cause differentiation. Targ...