- Glucocorticoid-Dependent Phosphorylation of the Transcriptional Coregulator GRIP1
[作者:Dobroyolna, J; Chinenov, Y; Kennedy, MA; Liu, B; Rogatsky, I,期刊:Molecular and Cellular Biology, 页码:730-739 , 文章类型: Article,,卷期:2012年32-4]
- Much of the regulatory diversity in eukaryotic transcription is provided by coregulators, which are recruited by DNA-binding factors to propagate signaling to basal machinery or chromatin. p160 family members, including ...
- Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction
[作者:Kienesberger, PC; Pulinilkunnil, T; Sung, MMY; Nagendran, J; Haemmerle, G; Kershaw, EE; Young, ME; Light, PE; Oudit, GY; Zechner, R; Dyck, JRB,期刊:Molecular and Cellular Biology, 页码:740-750 , 文章类型: Article,,卷期:2012年32-4]
- Alterations in myocardial triacylglycerol content have been associated with poor left ventricular function, suggesting that enzymes involved in myocardial triacylglycerol metabolism play an important role in regulating c...
- TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription
[作者:Montes, M; Cloutier, A; Sanchez-Hernandez, N; Michelle, L; Lemieux, B; Blanchette, M; Hernandez-Munain, C; Chabot, B; Sune, C,期刊:Molecular and Cellular Biology, 页码:751-762 , 文章类型: Article,,卷期:2012年32-4]
- Complex functional coupling exists between transcriptional elongation and pre-mRNA alternative splicing. Pausing sites and changes in the rate of transcription by RNA polymerase II (RNAPII) may therefore have fundamental...
- Integration of Elf-4 into Stem/Progenitor and Erythroid Regulatory Networks through Locus-Wide Chromatin Studies Coupled with In Vivo Functional Validation
[作者:Smith, AM; Calero-Nieto, FJ; Schutte, J; Kinston, S; Timms, RT; Wilson, NK; Hannah, RL; Landry, JR; Gottgens, B,期刊:Molecular and Cellular Biology, 页码:763-773 , 文章类型: Article,,卷期:2012年32-4]
- The ETS transcription factor Elf-4 is an important regulator of hematopoietic stem cell (HSC) and T cell homeostasis. To gain insights into the transcriptional circuitry within which Elf-4 operates, we used comparative s...
- Mannose 6 Dephosphorylation of Lysosomal Proteins Mediated by Acid Phosphatases Acp2 and Acp5
[作者:Makrypidi, G; Damme, M; Muller-Loennies, S; Trusch, M; Schmidt, B; Schluter, H; Heeren, J; Lubke, T; Saftig, P; Braulke, T,期刊:Molecular and Cellular Biology, 页码:774-782 , 文章类型: Article,,卷期:2012年32-4]
- Mannose 6-phosphate (Man6P) residues represent a recognition signal required for efficient receptor-dependent transport of soluble lysosomal proteins to lysosomes. Upon arrival, the proteins are rapidly dephosphorylated....
- Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail
[作者:Kim, K; Heo, K; Choi, J; Jackson, S; Kim, H; Xiong, Y; An, W,期刊:Molecular and Cellular Biology, 页码:783-796 , 文章类型: Article,,卷期:2012年32-4]
- HIV-1 Vpr-binding protein (VprBP) has been implicated in the regulation of both DNA replication and cell cycle progression, but its precise role remains unclear. Here we report that VprBP regulates the p53-induced transc...
- Phosphorylation of the Transcription Factor YY1 by CK2 alpha Prevents Cleavage by Caspase 7 during Apoptosis
[作者:Riman, S; Rizkallah, R; Kassardjian, A; Alexander, KE; Luscher, B; Hurt, MM,期刊:Molecular and Cellular Biology, 页码:797-807 , 文章类型: Article,,卷期:2012年32-4]
- In this report, we describe the phosphorylation of Yin Yang 1 (YY1) in vitro and in vivo by CK2 alpha (casein kinase II), a multifunctional serine/threonine protein kinase. YY1 is a ubiquitously expressed multifunctional...
- Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction
[作者:Okur, MN; Doi, J; Fong, CW; Martinez, N; Garcia-Dominguez, C; Rojas, JM; Guy, G; O'Bryana, JP,期刊:Molecular and Cellular Biology, 页码:817-825 , 文章类型: Article,,卷期:2012年32-4]
- Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking and lysosomal degradation of these important signaling molecules. We identified the multidomain scaffolding protein intersec...
- Prostate Apoptosis Response 4 (Par-4), a Novel Substrate of Caspase-3 during Apoptosis Activation
[作者:Chaudhry, P; Singh, M; Parent, S; Asselin, E,期刊:Molecular and Cellular Biology, 页码:826-839 , 文章类型: Article,,卷期:2012年32-4]
- Prostate apoptosis response 4 (Par-4) is a ubiquitously expressed proapoptotic tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of caspase-3 during apoptosis. We found that Par-...
- Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells
[作者:Neri, F; Zippo, A; Krepelova, A; Cherubini, A; Rocchigiani, M; Oliviero, S,期刊:Molecular and Cellular Biology, 页码:840-851 , 文章类型: Article,,卷期:2012年32-4]
- Myc family members are critical to maintain embryonic stem cells (ESC) in the undifferentiated state. However, the mechanism by which they perform this task has not yet been elucidated. Here we show that Myc directly upr...
- Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor alpha in Mouse Liver Reveals Extensive Sharing of Binding Sites
[作者:Boergesen, M; Pedersen, TA; Gross, B; van Heeringen, SJ; Hagenbeek, D; Bindesboll, C; Caron, S; Lalloyer, F; Steffensen, KR; Nebb, HI; Gustafsson, JA; Stunnenberg, HG; Staels, B; Mandrup, S,期刊:Molecular and Cellular Biology, 页码:852-867 , 文章类型: Article,,卷期:2012年32-4]
- The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We have recently shown that RXR agonist-i...
- Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis
[作者:Mikolcevic, P; Sigl, R; Rauch, V; Hess, MW; Pfaller, K; Barisic, M; Pelliniemi, LJ; Boesl, M; Geley, S,期刊:Molecular and Cellular Biology, 页码:868-879 , 文章类型: Article,,卷期:2012年32-4]
- Cyclin-dependent kinase 16 (CDK16, PCTK1) is a poorly characterized protein kinase, highly expressed in the testis and the brain. Here, we report that CDK16 is activated by membrane-associated cyclin Y (CCNY). Treatment ...
- Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver
[作者:Zhang, YJ; Laz, EV; Waxman, DJ,期刊:Molecular and Cellular Biology, 页码:880-896 , 文章类型: Article,,卷期:2012年32-4]
- Sex-dependent pituitary growth hormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat liver, affecting lipid and drug metabolism, inflammation, and disease. A fundamental bio...
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