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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb [作者：Matsumoto, K; Li, YC; Jakuba, C; Sugiyama, Y; Sayo, T; Okuno, M; Dealy, CN; Toole, BP; Takeda, J; Yamaguchi, Y; Kosher, RA,期刊：Development, 页码：2825-2835 , 文章类型： Article，,卷期：2009年136-16] The glycosaminoglycan hyaluronan ( HA) is a structural component of extracellular matrices and also interacts with cell surface receptors to directly influence cell behavior. To explore functions of HA in limb skeletal d... Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva [作者：Abbas, L; Whitfield, TT,期刊：Development, 页码：2837-2848 , 文章类型： Article，,卷期：2009年136-16] Endolymph is the specialised extracellular fluid present inside the inner ear. In mammals, disruptions to endolymph homeostasis can result in either collapse or distension of the endolymphatic compartment in the cochlea,... Wash functions downstream of Rho and links linear and branched actin nucleation factors [作者：Liu, R; Abreu-Blanco, MT; Barry, KC; Linardopoulou, EV; Osborn, GE; Parkhurst, SM,期刊：Development, 页码：2849-2860 , 文章类型： Article，,卷期：2009年136-16] Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/3 activators that mediate the branched-actin network formation required for cytoskeletal remodeling, intracellular transport and cell locomotion. Wasp and Scar/WAVE... Auxin transport routes in plant development [作者：Petrasek, J; Friml, J,期刊：Development, 页码：2675-2688 , 文章类型： Review，,卷期：2009年136-16] The differential distribution of the plant signaling molecule auxin is required for many aspects of plant development. Local auxin maxima and gradients arise as a result of local auxin metabolism and, predominantly, from... The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg [作者：Svendsen, PC; Formaz-Preston, A; Leal, SM; Brook, WJ,期刊：Development, 页码：2689-2693 , 文章类型： Article，,卷期：2009年136-16] Regional fates in the developing limbs of Drosophila melanogaster are controlled by selector gene transcription factors. Ventral fate in the fly leg is specified by the expression of the ligand Wingless. We present evide... Xenopus oocytes reactivate muscle gene transcription in transplanted somatic nuclei independently of myogenic factors [作者：Biddle, A; Simeoni, I; Gurdon, JB,期刊：Development, 页码：2695-2703 , 文章类型： Article，,卷期：2009年136-16] Transplantation into eggs or oocytes is an effective means of achieving the reprogramming of somatic cell nuclei. We ask here whether the provision of gene-specific transcription factors forms part of the mechanism by wh... Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans [作者：Kang, J; Shin, D; Yu, JR; Lee, J,期刊：Development, 页码：2705-2715 , 文章类型： Article，,卷期：2009年136-16] The roles of Lats kinases in the regulation of cell proliferation and apoptosis have been well established. Here we report new roles for Lats kinase in the integrity of the apical membrane structure. WTS-1, the C. elegan... beta 1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth [作者：Barros, CS; Nguyen, T; Spencer, KSR; Nishiyama, A; Colognato, H; Muller, U,期刊：Development, 页码：2717-2724 , 文章类型： Article，,卷期：2009年136-16] Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. beta 1 integrins regulate the myelination of peripheral nerves, but their f... UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration [作者：Meyerzon, M; Fridolfsson, HN; Ly, N; McNally, FJ; Starr, DA,期刊：Development, 页码：2725-2733 , 文章类型： Article，,卷期：2009年136-16] Intracellular nuclear migration is essential for many cellular events including fertilization, establishment of polarity, division and differentiation. How nuclei migrate is not understood at the molecular level. The C. ... The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C-elegans mesoderm development [作者：Broitman-Maduro, G; Owraghi, M; Hung, WWK; Kuntz, S; Sternberg, PW; Maduro, MF,期刊：Development, 页码：2735-2746 , 文章类型： Article，,卷期：2009年136-16] The C. elegans MS blastomere, born at the 7-cell stage of embryogenesis, generates primarily mesodermal cell types, including pharynx cells, body muscles and coelomocytes. A presumptive null mutation in the T-box factor ... Regulation of bone formation and remodeling by G-protein-coupled receptor 48 [作者：Luo, J; Zhou, W; Zhou, X; Li, DL; Weng, JS; Yi, ZF; Cho, SG; Li, CH; Yi, TF; Wu, XS; Li, XY; de Crombrugghe, B; Hook, M; Liu, MY,期刊：Development, 页码：2747-2756 , 文章类型： Article，,卷期：2009年136-16] G-protein-coupled receptor ( GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of unknown function. Using a knockout mouse model, we have charact... The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling [作者：Tao, SJ; Cai, Y; Sampath, K,期刊：Development, 页码：2757-2765 , 文章类型： Article，,卷期：2009年136-16] Hematopoiesis, the dynamic process of blood cell development, is regulated by the activity of the bone morphogenetic protein (BMP) signaling pathway and by many transcription factors. However, the molecules and mechanism... The apicobasal polarity kinase aPKC functions as a nuclear determinant and regulates cell proliferation and fate during Xenopus primary neurogenesis [作者：Sabherwal, N; Tsutsui, A; Hodge, S; Wei, J; Chalmers, AD; Papalopulu, N,期刊：Development, 页码：2767-2777 , 文章类型： Article，,卷期：2009年136-16] During neurogenesis in Xenopus, apicobasally polarised superficial and non-polar deep cells take up different fates: deep cells become primary neurons while superficial cells stay as progenitors. It is not known whether ... Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe [作者：Zhang, ZY; Zhu, XJ; Stevens, LM; Stein, D,期刊：Development, 页码：2779-2789 , 文章类型： Article，,卷期：2009年136-16] Spatially regulated transcription of the pipe gene in ventral cells of the Drosophila ovary follicle cell epithelium is a key event that specifies progeny embryo dorsal-ventral ( DV) polarity. pipe encodes ten putative p... beta 1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells [作者：Breau, MA; Dahmani, A; Broders-Bondon, F; Thiery, JP; Dufour, S,期刊：Development, 页码：2791-2801 , 文章类型： Article，,卷期：2009年136-16] Integrins are the major adhesive receptors for extracellular matrix and have various roles in development. To determine their role in cell migration, the gene encoding the beta 1 integrin subunit (Itgb1) was conditionall... Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus [作者：Hagemann, AI; Xu, X; Nentwich, O; Hyvonen, M; Smith, JC,期刊：Development, 页码：2803-2813 , 文章类型： Article，,卷期：2009年136-16] Morphogen gradients provide positional cues for cell fate specification and tissue patterning during embryonic development. One important aspect of morphogen function, the mechanism by which long-range signalling occurs,...