- Formin mDia1 Mediates Vascular Remodeling via Integration of Oxidative and Signal Transduction Pathways
[作者:Toure, F; Fritz, G; Li, Q; Rai, V; Daffu, G; Zou, YS; Rosario, R; Ramasamy, R; Alberts, AS; Yan, SF; Schmidt, AM,期刊:Circulation Research, 页码:1279-+ , 文章类型: Article,,卷期:2012年110-10]
- Rationale: The mammalian diaphanous-related formin (mDia1), governs microtubule and microfilament dynamics while functioning as an effector for Rho small GTP-binding proteins during key cellular processes such as adhesio...
- Myeloid-Specific Kruppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis
[作者:Lingrel, JB; Pilcher-Roberts, R; Basford, JE; Manoharan, P; Neumann, J; Konaniah, ES; Srinivasan, R; Bogdanov, VY; Hui, DY,期刊:Circulation Research, 页码:1294-U76 , 文章类型: Article,,卷期:2012年110-10]
- Rationale: Hemizygous deficiency of the transcription factor Kruppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice. However, the cell type responsible for the incr...
- Localization of Islet-1-Positive Cells in the Healthy and Infarcted Adult Murine Heart
[作者:Weinberger, F; Mehrkens, D; Friedrich, FW; Stubbendorff, M; Hua, XQ; Muller, JC; Schrepfer, S; Evans, SM; Carrier, L; Eschenhagen, T,期刊:Circulation Research, 页码:1303-U95 , 文章类型: Article,,卷期:2012年110-10]
- Rationale: The transcription factor Islet-1 is a marker of cardiovascular progenitors during embryogenesis. The isolation of Islet-1-positive (Islet-1(+)) cells from early postnatal hearts suggested that Islet-1 also mar...
- Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction A Critical Role of the Angiotensin II/AT1 Receptor Axis
[作者:Patel, VB; Bodiga, S; Basu, R; Das, SK; Wang, W; Wang, ZC; Lo, J; Grant, MB; Zhong, JC; Kassiri, Z; Oudit, GY,期刊:Circulation Research, 页码:1322-U146 , 文章类型: Article,,卷期:2012年110-10]
- Rationale: Diabetic cardiovascular complications are reaching epidemic proportions. Angiotensin-converting enzyme-2 (ACE2) is a negative regulator of the renin-angiotensin system. We hypothesize that loss of ACE2 exacerb...
- Endothelial Cell Palmitoylproteomic Identifies Novel Lipid-Modified Targets and Potential Substrates for Protein Acyl Transferases
[作者:Marin, EP; Derakhshan, B; Lam, TT; Davalos, A; Sessa, WC,期刊:Circulation Research, 页码:1336-U173 , 文章类型: Article,,卷期:2012年110-10]
- Rationale: Protein S-palmitoylation is the posttranslational attachment of a saturated 16-carbon palmitic acid to a cysteine side chain via a thioester bond. Palmitoylation can affect protein localization, trafficking, s...
- Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
[作者:Lassegue, B; San Martin, A; Griendling, KK,期刊:Circulation Research, 页码:1364-1390 , 文章类型: Review,,卷期:2012年110-10]
- The NADPH oxidase (Nox) enzymes are critical mediators of cardiovascular physiology and pathophysiology. These proteins are expressed in virtually all cardiovascular cells, and regulate such diverse functions as differen...
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