- Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47
[作者:Kaur, S; Martin-Manso, G; Pendrak, ML; Garfield, SH; Isenberg, JS; Roberts, DD,期刊:Journal of Biological Chemistry, 页码:38923-38932 , 文章类型: Article,,卷期:2010年285-50]
- Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors. We now describe a more potent mechanism by which TSP1 inhibit...
- Increase in 4-Coumaryl Alcohol Units during Lignification in Alfalfa (Medicago sativa) Alters the Extractability and Molecular Weight of Lignin
[作者:Ziebell, A; Gracom, K; Katahira, R; Chen, F; Pu, YQ; Ragauskas, A; Dixon, RA; Davis, M,期刊:Journal of Biological Chemistry, 页码:38961-38968 , 文章类型: Article,,卷期:2010年285-50]
- The lignin content of biomass can impact the ease and cost of biomass processing. Lignin reduction through breeding and genetic modification therefore has potential to reduce costs in biomass-processing industries (e. g....
- Selective Electrodiffusion of Zinc Ions in a Zrt-, Irt-like Protein, ZIPB
[作者:Lin, W; Chai, J; Love, J; Fu, D,期刊:Journal of Biological Chemistry, 页码:39013-39020 , 文章类型: Article,,卷期:2010年285-50]
- All living cells need zinc ions to support cell growth. Zrt-, Irt-like proteins (ZIPs) represent a major route for entry of zinc ions into cells, but how ZIPs promote zinc uptake has been unclear. Here we report the mole...
- Matriptase-2-and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression
[作者:Maxson, JE; Chen, JX; Enns, CA; Zhang, AS,期刊:Journal of Biological Chemistry, 页码:39021-39028 , 文章类型: Article,,卷期:2010年285-50]
- Hemojuvelin (HJV) is an important regulator of iron metabolism. Membrane-anchored HJV up-regulates expression of the iron regulatory hormone, hepcidin, through the bone morphogenic protein (BMP) signaling pathway by acti...
- The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development
[作者:Sun, YM; Fei, T; Yang, T; Zhang, F; Chen, YG; Li, HS; Xu, ZH,期刊:Journal of Biological Chemistry, 页码:39039-39050 , 文章类型: Article,,卷期:2010年285-50]
- The formation of the functional mammalian cerebral cortex requires a concerted control of neurogenesis, neuronal migration, and neuronal morphogenesis. However, molecular mechanisms that control these processes are not w...
- Angiotensin-converting Enzyme Overexpression in Mouse Myelomonocytic Cells Augments Resistance to Listeria and Methicillin-resistant Staphylococcus aureus
[作者:Okwan-Duodu, D; Datta, V; Shen, XZ; Goodridge, HS; Bernstein, EA; Fuchs, S; Liu, GY; Bernstein, KE,期刊:Journal of Biological Chemistry, 页码:39051-39060 , 文章类型: Article,,卷期:2010年285-50]
- Gene targeting in ES cells was used to substitute control of angiotensin converting enzyme (ACE) expression from the endogenous promoter to the mouse c-fms promoter. The result is an animal model called ACE 10/10 in whic...
- Identification and Functions of Amino Acid Residues in PotB and PotC Involved in Spermidine Uptake Activity
[作者:Higashi, K; Sakamaki, Y; Herai, E; Demizu, R; Uemura, T; Saroj, SD; Zenda, R; Terui, Y; Nishimura, K; Toida, T; Kashiwagi, K; Igarashi, K,期刊:Journal of Biological Chemistry, 页码:39061-39069 , 文章类型: Article,,卷期:2010年285-50]
- Amino acid residues on PotB and PotC involved in spermidine uptake were identified by random and site-directed mutagenesis. It was found that Trp(8), Tyr(43), Trp(100), Leu(110), and Tyr(261) in PotB and Trp(46), Asp(108...
- Structure and Molecular Assignment of Lactococcal Phage TP901-1 Baseplate
[作者:Bebeacua, C; Bron, P; Lai, L; Vegge, CS; Brondsted, L; Spinelli, S; Campanacci, V; Veesler, D; van Heel, M; Cambillau, C,期刊:Journal of Biological Chemistry, 页码:39079-39086 , 文章类型: Article,,卷期:2010年285-50]
- P335 lactococcal phages infect the Gram(+) bacterium Lactococcus lactis using a large multiprotein complex located at the distal part of the tail and termed baseplate (BP). The BP harbors the receptor-binding proteins (R...
- O-Linked beta-N-acetylglucosamine (O-GlcNAc) Regulates Stress-induced Heat Shock Protein Expression in a GSK-3 beta-dependent Manner
[作者:Kazemi, Z; Chang, HN; Haserodt, S; McKen, C; Zachara, NE,期刊:Journal of Biological Chemistry, 页码:39096-39107 , 文章类型: Article,,卷期:2010年285-50]
- To investigate the mechanisms by which O-linked beta-N-acetylglucosamine modification of nucleocytoplasmic proteins (O-GlcNAc) confers stress tolerance to multiple forms of cellular injury, we explored the role(s) of O-G...
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