- Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82
[作者:Alymova, IV; Green, AM; van de Velde, N; McAuley, JL; Boyd, KL; Ghoneim, HE; McCullers, JA,期刊:Journal of virology, 页码:12324-12333 , 文章类型: Article,,卷期:2011年85-23]
- The influenza A virus protein PB1-F2 has been linked to the pathogenesis of both primary viral and secondary bacterial infections. H3N2 viruses have historically expressed full-length PB1-F2 proteins with either proinfla...
- Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
[作者:Lam, AM; Espiritu, C; Bansal, S; Steuer, HMM; Zennou, V; Otto, MJ; Furman, PA,期刊:Journal of virology, 页码:12334-12342 , 文章类型: Article,,卷期:2011年85-23]
- PSI-352938, a cyclic phosphate nucleotide, and PSI-353661, a phosphoramidate nucleotide, are prodrugs of beta-D-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methylguanosine-5'-monophosphate. Both compounds are metabolized to the s...
- HIV-1 Infection Abrogates CD8(+) T Cell Mitogen-Activated Protein Kinase Signaling Responses
[作者:Crawford, TQ; Ndhlovu, LC; Tan, A; Carvidi, A; Hecht, FM; Sinclair, E; Barbour, JD,期刊:Journal of virology, 页码:12343-12350 , 文章类型: Article,,卷期:2011年85-23]
- Mitogen- activated protein kinase (MAPK) signaling pathways are dynamic and sensitive regulators of T cell function and differentiation. Altered MAPK signaling has been associated with the inflammatory and autoimmune dis...
- A Genetic Interaction between the Core and NS3 Proteins of Hepatitis C Virus Is Essential for Production of Infectious Virus
[作者:Jones, DM; Atoom, AM; Zhang, XZ; Kottilil, S; Russell, RS,期刊:Journal of virology, 页码:12351-12361 , 文章类型: Article,,卷期:2011年85-23]
- By analogy to other members of the Flaviviridae family, the hepatitis C virus (HCV) core protein is presumed to oligomerize to form the viral nucleocapsid, which encloses the single-stranded RNA genome. Core protein is d...
- Epstein-Barr Virus BamHI W Repeat Number Limits EBNA2/EBNA-LP Coexpression in Newly Infected B Cells and the Efficiency of B-Cell Transformation: a Rationale for the Multiple W Repeats in Wild-Type Virus Strains
[作者:Tierney, RJ; Kao, KY; Nagra, JK; Rickinson, AB,期刊:Journal of virology, 页码:12362-12375 , 文章类型: Article,,卷期:2011年85-23]
- The genome of Epstein-Barr virus (EBV), a gammaherpesvirus with potent B-cell growth-transforming ability, contains multiple copies of a 3-kb BamHI W repeat sequence; each repeat carries (i) a promoter (Wp) that initiate...
- Human Cytomegalovirus Induces Multiple Means To Combat Reactive Oxygen Species
[作者:Tilton, C; Clippinger, AJ; Maguire, T; Alwine, JC,期刊:Journal of virology, 页码:12585-12593 , 文章类型: Article,,卷期:2011年85-23]
- Reactive oxygen species (ROS) are generated as by-products of many cellular processes and can modulate cellular signaling pathways. However, high ROS levels are toxic; thus, intracellular ROS need to be tightly controlle...
- Nonconsensus West Nile Virus Genomes Arising during Mosquito Infection Suppress Pathogenesis and Modulate Virus Fitness In Vivo
[作者:Ebel, GD; Fitzpatrick, KA; Lim, PY; Bennett, CJ; Deardorff, ER; Jerzak, GVS; Kramer, LD; Zhou, YS; Shi, PY; Bernard, KA,期刊:Journal of virology, 页码:12605-12613 , 文章类型: Article,,卷期:2011年85-23]
- West Nile virus (WNV) is similar to other RNA viruses in that it forms genetically complex populations within hosts. The virus is maintained in nature in mosquitoes and birds, with each host type exerting distinct influe...
- Three-Dimensional Structures of Soluble CD4-Bound States of Trimeric Simian Immunodeficiency Virus Envelope Glycoproteins Determined by Using Cryo-Electron Tomography
[作者:White, TA; Bartesaghi, A; Borgnia, MJ; de la Cruz, MJV; Nandwani, R; Hoxie, JA; Bess, JW; Lifson, JD; Milne, JLS; Subramaniam, S,期刊:Journal of virology, 页码:12114-12123 , 文章类型: Article,,卷期:2011年85-23]
- The trimeric envelope glycoprotein (Env) spikes displayed on the surfaces of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) virions are composed of three heterodimers of the viral gly...
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