- HLA-DR(+) CD38(+) CD4(+) T Lymphocytes Have Elevated CCR5 Expression and Produce the Majority of R5-Tropic HIV-1 RNA In Vivo
[作者:Meditz, AL; Haas, MK; Folkvord, JM; Melander, K; Young, R; McCarter, M; MaWhinney, S; Campbell, TB; Lie, Y; Coakley, E; Levy, DN; Connick, E,期刊:Journal of virology, 页码:10189-10200 , 文章类型: Article,,卷期:2011年85-19]
- Percentages of activated T cells correlate with HIV-1 disease progression, but the underlying mechanisms are not fully understood. We hypothesized that HLA-DR(+) CD38(+) (DR(+) 38(+)) CD4(+) T cells produce the majority ...
- Plasmid Vector-Linked Maturation of Natural Killer (NK) Cells Is Coupled to Antigen-Dependent NK Cell Activation during DNA-Based Immunization in Mice
[作者:Zhu, R; Mancini-Bourgine, M; Zhang, XM; Bayard, F; Deng, Q; Michel, ML,期刊:Journal of virology, 页码:10201-10212 , 文章类型: Article,,卷期:2011年85-19]
- Plasmid DNA vaccines serve in a wide array of applications ranging from prophylactic vaccines to potential therapeutic tools against infectious diseases and cancer. In this study, we analyzed the mechanisms underlying th...
- Generation of Replication-Defective Virus-Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus Challenge
[作者:Matsuo, E; Celma, CCP; Boyce, M; Viarouge, C; Sailleau, C; Dubois, E; Breard, E; Thiery, R; Zientara, S; Roy, P,期刊:Journal of virology, 页码:10213-10221 , 文章类型: Article,,卷期:2011年85-19]
- The reverse genetics technology for bluetongue virus (BTV) has been used in combination with complementing cell lines to recover defective BTV-1 mutants. To generate a potential disabled infectious single cycle (DISC) va...
- Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Virus Pathogenesis
[作者:Yang, ML; Chen, YH; Wang, SW; Huang, YJ; Leu, CH; Yeh, NC; Chu, CY; Lin, CC; Shieh, GS; Chen, YL; Wang, JR; Wang, CH; Wu, CL; Shiau, AL,期刊:Journal of virology, 页码:10010-10020 , 文章类型: Article,,卷期:2011年85-19]
- Innate immune response is important for viral clearance during influenza virus infection. Galectin-1, which belongs to S-type lectins, contains a conserved carbohydrate recognition domain that recognizes galactose-contai...
- Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues
[作者:Wang, J; Fan, TT; Yao, X; Wu, ZQ; Guo, L; Lei, XB; Wang, JW; Wang, MT; Jin, Q; Cui, S,期刊:Journal of virology, 页码:10021-10030 , 文章类型: Article,,卷期:2011年85-19]
- EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities ...
- Mutational Analysis of the Hypervariable Region of Hepatitis E Virus Reveals Its Involvement in the Efficiency of Viral RNA Replication
[作者:Pudupakam, RS; Kenney, SP; Cordoba, L; Huang, YW; Dryman, BA; LeRoith, T; Pierson, FW; Meng, XJ,期刊:Journal of virology, 页码:10031-10040 , 文章类型: Article,,卷期:2011年85-19]
- The RNA genome of the hepatitis E virus (HEV) contains a hypervariable region (HVR) in ORF1 that tolerates small deletions with respect to infectivity. To further investigate the role of the HVR in HEV replication, we co...
- Systematic Analysis of the Amino Acid Residues of Human Papillomavirus Type 16 E7 Conserved Region 3 Involved in Dimerization and Transformation
[作者:Todorovic, B; Massimi, P; Hung, K; Shaw, GS; Banks, L; Mymryk, JS,期刊:Journal of virology, 页码:10048-10057 , 文章类型: Article,,卷期:2011年85-19]
- The human papillomavirus (HPV) E7 oncoprotein exists as a dimer and acts by binding to many cellular factors, preventing or retargeting their function and thereby making the infected cell conducive for viral replication....
- Cell-Type-Specific Type I Interferon Antagonism Influences Organ Tropism of Murine Coronavirus
[作者:Zhao, L; Rose, KM; Elliott, R; Van Rooijen, N; Weiss, SR,期刊:Journal of virology, 页码:10058-10068 , 文章类型: Article,,卷期:2011年85-19]
- Previous studies have demonstrated that mouse hepatitis virus (MHV) hepatotropism is determined largely by postentry events rather than by availability of the viral receptor. In addition, mutation of MHV nonstructural pr...
- The Acheta domesticus Densovirus, Isolated from the European House Cricket, Has Evolved an Expression Strategy Unique among Parvoviruses
[作者:Liu, KY; Li, Y; Jousset, FX; Zadori, Z; Szelei, J; Yu, Q; Pham, HT; Lepine, F; Bergoin, M; Tijssen, P,期刊:Journal of virology, 页码:10069-10078 , 文章类型: Article,,卷期:2011年85-19]
- The Acheta domesticus densovirus (AdDNV), isolated from crickets, has been endemic in Europe for at least 35 years. Severe epizootics have also been observed in American commercial rearings since 2009 and 2010. The AdDNV...
- Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1
[作者:Koh, Y; Aoki, M; Danish, ML; Aoki-Ogata, H; Amano, M; Das, D; Shafer, RW; Ghosh, AK; Mitsuya, H,期刊:Journal of virology, 页码:10079-10089 , 文章类型: Article,,卷期:2011年85-19]
- Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, ...
- Multiple Functional Domains and Complexes of the Two Nonstructural Proteins of Human Respiratory Syncytial Virus Contribute to Interferon Suppression and Cellular Location
[作者:Swedan, S; Andrews, J; Majumdar, T; Musiyenko, A; Barik, S,期刊:Journal of virology, 页码:10090-10100 , 文章类型: Article,,卷期:2011年85-19]
- Human respiratory syncytial virus (RSV), a major cause of severe respiratory diseases, efficiently suppresses cellular innate immunity, represented by type I interferon (IFN), using its two unique nonstructural proteins,...
- Type 1 Responses of Human V gamma 9V delta 2 T Cells to Influenza A Viruses
[作者:Qin, G; Liu, YP; Zheng, J; Ng, IHY; Xiang, Z; Lam, KT; Mao, HW; Li, H; Peiris, JSM; Lau, YL; Tu, WW,期刊:Journal of virology, 页码:10109-10116 , 文章类型: Article,,卷期:2011年85-19]
- gamma delta T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human V gamma 9V delta 2 T cells participated...
- Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells
[作者:Belser, JA; Zeng, H; Katz, JM; Tumpey, TM,期刊:Journal of virology, 页码:10117-10125 , 文章类型: Article,,卷期:2011年85-19]
- Highly pathogenic avian influenza (HPAI) H7 virus infection in humans frequently results in conjunctivitis as a major symptom. However, our understanding of what properties govern virus subtype-specific tropism, and of t...
- Gamma Interferon Controls Mouse Polyomavirus Infection In Vivo
[作者:Wilson, JJ; Lin, E; Pack, CD; Frost, EL; Hadley, A; Swimm, AI; Wang, J; Dong, Y; Breeden, CP; Kalman, D; Newell, KA; Lukacher, AE,期刊:Journal of virology, 页码:10126-10134 , 文章类型: Article,,卷期:2011年85-19]
- Human polyomaviruses are associated with substantial morbidity in immunocompromised patients, including those with HIV/AIDS, recipients of bone marrow and kidney transplants, and individuals receiving immunomodulatory ag...
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