- On Getting There from Here
[作者:McKnight, SL,期刊:Science, 页码:1338-1339 , 文章类型: Article,,卷期:2010年330-6009]
- Studies on a variety of interesting biological problems, ranging from circadian rhythm to cancer cell growth to longevity, have begun to give evidence that the physiological state of cells and tissues reflects both the c...
- Autophagy and Metabolism
[作者:Rabinowitz, JD; White, E,期刊:Science, 页码:1344-1348 , 文章类型: Review,,卷期:2010年330-6009]
- Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and organelles and consume them in lysosomes. The resulting breakdown products are inputs to cellular metabolism, through which they are u...
- Circadian Integration of Metabolism and Energetics
[作者:Bass, J; Takahashi, JS,期刊:Science, 页码:1349-1354 , 文章类型: Review,,卷期:2010年330-6009]
- Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic...
- How Learning to Read Changes the Cortical Networks for Vision and Language
[作者:Dehaene, S; Pegado, F; Braga, LW; Ventura, P; Nunes, G; Jobert, A; Dehaene-Lambertz, G; Kolinsky, R; Morais, J; Cohen, L,期刊:Science, 页码:1359-1364 , 文章类型: Article,,卷期:2010年330-6009]
- Does literacy improve brain function? Does it also entail losses? Using functional magnetic resonance imaging, we measured brain responses to spoken and written language, visual faces, houses, tools, and checkers in adul...
- Carbon Nanotubes with Temperature-Invariant Viscoelasticity from-196 degrees to 1000 degrees C
[作者:Xu, M; Futaba, DN; Yamada, T; Yumura, M; Hata, K,期刊:Science, 页码:1364-1368 , 文章类型: Article,,卷期:2010年330-6009]
- Viscoelasticity describes the ability of a material to possess both elasticity and viscosity. Viscoelastic materials, such as rubbers, possess a limited operational temperature range (for example, for silicone rubber it ...
- Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering
[作者:Saar, BG; Freudiger, CW; Reichman, J; Stanley, CM; Holtom, GR; Xie, XS,期刊:Science, 页码:1368-1370 , 文章类型: Article,,卷期:2010年330-6009]
- Optical imaging in vivo with molecular specificity is important in biomedicine because of its high spatial resolution and sensitivity compared with magnetic resonance imaging. Stimulated Raman scattering (SRS) microscopy...
- A Cryptic Sulfur Cycle in Oxygen-Minimum-Zone Waters off the Chilean Coast
[作者:Canfield, DE; Stewart, FJ; Thamdrup, B; De Brabandere, L; Dalsgaard, T; Delong, EF; Revsbech, NP; Ulloa, O,期刊:Science, 页码:1375-1378 , 文章类型: Article,,卷期:2010年330-6009]
- Nitrogen cycling is normally thought to dominate the biogeochemistry and microbial ecology of oxygen-minimum zones in marine environments. Through a combination of molecular techniques and process rate measurements, we s...
- Dynamical Response of the Tropical Pacific Ocean to Solar Forcing During the Early Holocene
[作者:Marchitto, TM; Muscheler, R; Ortiz, JD; Carriquiry, JD; van Geen, A,期刊:Science, 页码:1378-1381 , 文章类型: Article,,卷期:2010年330-6009]
- We present a high-resolution magnesium/calcium proxy record of Holocene sea surface temperature (SST) from off the west coast of Baja California Sur, Mexico, a region where interannual SST variability is dominated today ...
- Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate
[作者:Denoeud, F; Henriet, S; Mungpakdee, S; Aury, JM; Da Silva, C; Brinkmann, H; Mikhaleva, J; Olsen, LC; Jubin, C; Canestro, C; Bouquet, JM; Danks, G; Poulain, J; Campsteijn, C; Adamski, M; Cross, I; Yadetie, F; Muffato, M; Louis, A; Butcher, S; Tsagkogeorga,,期刊:Science, 页码:1381-1385 , 文章类型: Article,,卷期:2010年330-6009]
- Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene ord...
- Rewiring of Genetic Networks in Response to DNA Damage
[作者:Bandyopadhyay, S; Mehta, M; Kuo, D; Sung, MK; Chuang, R; Jaehnig, EJ; Bodenmiller, B; Licon, K; Copeland, W; Shales, M; Fiedler, D; Dutkowski, J; Guenole, A; van Attikum, H; Shokat, KM; Kolodner, RD; Huh, WK; Aebersold, R; Keogh, MC; Krogan, NJ; Ideker, T,期刊:Science, 页码:1385-1389 , 文章类型: Article,,卷期:2010年330-6009]
- Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread cha...
- BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
[作者:Ren, DC; Tu, HC; Kim, H; Wang, GX; Bean, GR; Takeuchi, O; Jeffers, JR; Zambetti, GP; Hsieh, JJD; Cheng, EHY,期刊:Science, 页码:1390-1393 , 文章类型: Article,,卷期:2010年330-6009]
- Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in vivo evidence demonstrating an essential role of the proteins...
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