- The Joy of Six: How to Control Your Crossovers
[作者：Globus, ST; Keeney, S,期刊：Cell, 页码：11-12 , 文章类型： Editorial Material，,卷期：2012年149-1]
- Meiotic cells tightly regulate the number and distribution of crossovers to promote accurate chromosome segregation. Yokoo and colleagues uncover a metazoan-specific, cyclin-like protein that is crucial for crossover for...
- Deconstructing the Complexity of a Microenvironmental Niche
[作者：Krause, DS; Scadden, DT,期刊：Cell, 页码：16-17 , 文章类型： Editorial Material，,卷期：2012年149-1]
- Cells acquire their fate in vivo in the context of a complex microenvironmental "niche" comprised of heterologous cell types, signaling molecules, extracellular matrix, biophysical forces, and metabolic substrates. Now C...
- COPII Vesicles Get Supersized by Ubiquitin
[作者：Malhotra, V,期刊：Cell, 页码：20-21 , 文章类型： Editorial Material，,卷期：2012年149-1]
- Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Natur...
- MYC on the Path to Cancer
[作者：Dang, CV,期刊：Cell, 页码：22-35 , 文章类型： Review，,卷期：2012年149-1]
- The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC's activation by bromodomain proteins could be inhibited by dr...
- Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells
[作者：Chen, J; Mckay, RM; Parada, LF,期刊：Cell, 页码：36-47 , 文章类型： Review，,卷期：2012年149-1]
- Eighty percent of malignant tumors that develop in the central nervous system are malignant gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies are identifying unexpected drivers of g...
- Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
[作者：Garcia-Cao, I; Song, MS; Hobbs, RM; Laurent, G; Giorgi, C; de Boer, VCJ; Anastasiou, D; Ito, K; Sasaki, AT; Rameh, L; Carracedo, A; Vander Heiden, MG; Cantley, LC; Pinton, P; Haigis, MC; Pandolfi, PP,期刊：Cell, 页码：49-62 , 文章类型： Article，,卷期：2012年149-1]
- Decremental loss of PTEN results in cancer susceptibility and tumor progression. PTEN elevation might therefore be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines ...
- The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO
[作者：Rankin, EB; Wu, C; Khatri, R; Wilson, TLS; Andersen, R; Araldi, E; Rankin, AL; Yuan, J; Kuo, CJ; Schipani, E; Giaccia, AJ,期刊：Cell, 页码：63-74 , 文章类型： Article，,卷期：2012年149-1]
- Osteoblasts are an important component of the hematopoietic microenvironment in bone. However, the mechanisms by which osteoblasts control hematopoiesis remain unknown. We show that augmented HIF signaling in osteoprogen...
- COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers
[作者：Yokoo, R; Zawadzki, KA; Nabeshima, K; Drake, M; Arur, S; Villeneuve, AM,期刊：Cell, 页码：75-87 , 文章类型： Article，,卷期：2012年149-1]
- Crossovers (COs) between homologous chromosomes ensure their faithful segregation during meiosis. We identify C. elegans COSA-1, a cyclin-related protein conserved in metazoa, as a key component required to convert meiot...
- Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translation Repression
[作者：Yao, P; Potdar, AA; Arif, A; Ray, PS; Mukhopadhyay, R; Willard, B; Xu, YC; Yan, J; Saidel, GM; Fox, PL,期刊：Cell, 页码：88-100 , 文章类型： Article，,卷期：2012年149-1]
- Posttranscriptional regulatory mechanisms superimpose "fine-tuning" control upon "on-off" switches characteristic of gene transcription. We have exploited computational modeling with experimental validation to resolve an...
- A Role for Small RNAs in DNA Double-Strand Break Repair
[作者：Wei, W; Ba, ZQ; Gao, M; Wu, Y; Ma, YT; Amiard, S; White, CI; Danielsen, JMR; Yang, YG; Qi, YJ,期刊：Cell, 页码：101-112 , 文章类型： Article，,卷期：2012年149-1]
- Eukaryotes have evolved complex mechanisms to repair DNA double-strand breaks (DSBs) through coordinated actions of protein sensors, transducers, and effectors. Here we show that similar to 21-nucleotide small RNAs are p...
- ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin
[作者：Clare, DK; Vasishtan, D; Stagg, S; Quispe, J; Farr, GW; Topf, M; Horwich, AL; Saibil, HR,期刊：Cell, 页码：113-123 , 文章类型： Article，,卷期：2012年149-1]
- The chaperonin GroEL assists the folding of nascent or stress-denatured polypeptides by actions of binding and encapsulation. ATP binding initiates a series of conformational changes triggering the association of the coc...
- Membrane Fission Is Promoted by Insertion of Amphipathic Helices and Is Restricted by Crescent BAR Domains
[作者：Boucrot, E; Pick, A; Camdere, G; Liska, N; Evergren, E; McMahon, HT; Kozlov, MM,期刊：Cell, 页码：124-136 , 文章类型： Article，,卷期：2012年149-1]
- Shallow hydrophobic insertions and crescent-shaped BAR scaffolds promote membrane curvature. Here, we investigate membrane fission by shallow hydrophobic insertions quantitatively and mechanistically. We provide evidence...
- Structural Basis of Membrane Bending by the N-BAR Protein Endophilin
[作者：Mim, C; Cui, HS; Gawronski-Salerno, JA; Frost, A; Lyman, E; Voth, GA; Unger, VM,期刊：Cell, 页码：137-145 , 文章类型： Article，,卷期：2012年149-1]
- Functioning as key players in cellular regulation of membrane curvature, BAR domain proteins bend bilayers and recruit interaction partners through poorly understood mechanisms. Using electron cryo-microscopy, we present...
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