- Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation
[作者：Li, GL; Ruan, XA; Auerbach, RK; Sandhu, KS; Zheng, MZ; Wang, P; Poh, HM; Goh, Y; Lim, J; Zhang, JY; Sim, HS; Peh, SQ; Mulawadi, FH; Ong, CT; Orlov, YL; Hong, SZ; Zhang, ZZ; Landt, S; Raha, D; Euskirchen, G; Wei, CL; Ge, WH; Wang, HE; Davis, C; Fisher-Aylor, KI; Mortazavi, A; Gerstein, M; Gingeras, T; Wold, B; Sun, Y; Fullwood, MJ; Cheung, E; Liu, E; Sung, WK; Snyder, M; Ruan, YJ,期刊：Cell, 页码：84-98 , 文章类型： Article，,卷期：2012年148-1-2]
- Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chro...
- Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae
[作者：Knott, SRV; Peace, JM; Ostrow, AZ; Gan, Y; Rex, AE; Viggiani, CJ; Tavare, S; Aparicio, OM,期刊：Cell, 页码：99-111 , 文章类型： Article，,卷期：2012年148-1-2]
- The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timing of specific origins is...
- A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division
[作者：Rocheteau, P; Gayraud-Morel, B; Siegl-Cachedenier, I; Blasco, MA; Tajbakhsh, S,期刊：Cell, 页码：112-125 , 文章类型： Article，,卷期：2012年148-1-2]
- Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly defined heterogeneous population. Using transgenic Tg:Pax7-nGFP mice, we show that Pax7-nGFP(Hi) cells are less primed for c...
- A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
[作者：Nobile, CJ; Fox, EP; Nett, JE; Sorrells, TR; Mitrovich, QM; Hernday, AD; Tuch, BB; Andes, DR; Johnson, AD,期刊：Cell, 页码：126-138 , 文章类型： Article，,卷期：2012年148-1-2]
- A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, we describe and analyze th...
- RNA Dynamics in Aging Bacterial Spores
[作者：Segev, E; Smith, Y; Ben-Yehuda, S,期刊：Cell, 页码：139-149 , 文章类型： Article，,卷期：2012年148-1-2]
- Upon starvation, the bacterium Bacillus subtilis enters the process of sporulation, lasting several hours and culminating in formation of a spore, the most resilient cell type known. We show that a few days following spo...
- Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore Delta F508 CFTR Folding and Function
[作者：Rabeh, WM; Bossard, F; Xu, HJ; Okiyoneda, T; Bagdany, M; Mulvihill, CM; Du, K; di Bernardo, S; Liu, YH; Konermann, L; Roldan, A; Lukacs, GL,期刊：Cell, 页码：150-163 , 文章类型： Article，,卷期：2012年148-1-2]
- The folding and misfolding mechanism of multidomain proteins remains poorly understood. Although thermodynamic instability of the first nucleotide-binding domain (NBD1) of Delta F508 CFTR (cystic fibrosis transmembrane c...
- Requirements for Efficient Correction of Delta F508 CFTR Revealed by Analyses of Evolved Sequences
[作者：Mendoza, JL; Schmidt, A; Li, Q; Nuvaga, E; Barrett, T; Bridges, RJ; Feranchak, AP; Brautigam, CA; Thomas, PJ,期刊：Cell, 页码：164-174 , 文章类型： Article，,卷期：2012年148-1-2]
- Misfolding of Delta F508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR) underlies pathology in most CF patients. F508 resides in the first nucleotide-binding domain (NBD1) of CFTR near a predicted interf...
- Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration
[作者：Houk, AR; Jilkine, A; Mejean, CO; Boltyanskiy, R; Dufresne, ER; Angenent, SB; Altschuler, SJ; Wu, LF; Weiner, OD,期刊：Cell, 页码：175-188 , 文章类型： Article，,卷期：2012年148-1-2]
- Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating lon...
- Coordinated Ciliary Beating Requires Odf2-Mediated Polarization of Basal Bodies via Basal Feet
[作者：Kunimoto, K; Yamazaki, Y; Nishida, T; Shinohara, K; Ishikawa, H; Hasegawa, T; Okanoue, T; Hamada, H; Noda, T; Tamura, A; Tsukita, S; Tsukita, S,期刊：Cell, 页码：189-200 , 文章类型： Article，,卷期：2012年148-1-2]
- Coordinated beating of cilia in the trachea generates a directional flow of mucus required to clear the airways. Each cilium originates from a barrel-shaped basal body, from the side of which protrudes a structure known ...
- Endoplasmic Reticulum PI(3)P Lipid Binding Targets Malaria Proteins to the Host Cell
[作者：Bhattacharjee, S; Stahelin, RV; Speicher, KD; Speicher, DW; Haldar, K,期刊：Cell, 页码：201-212 , 文章类型： Article，,卷期：2012年148-1-2]
- Hundreds of effector proteins of the human malaria parasite Plasmodium falciparum constitute a "secretome" carrying a host-targeting (HT) signal, which predicts their export from the intracellular pathogen into the surro...
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
[作者：Sun, LM; Wang, HY; Wang, ZG; He, SD; Chen, S; Liao, DH; Wang, L; Yan, JC; Liu, WL; Lei, XG; Wang, XD,期刊：Cell, 页码：213-227 , 文章类型： Article，,卷期：2012年148-1-2]
- The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiological and pathological co...
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
[作者：Freed-Pastor, WA; Mizuno, H; Zhao, X; Langerod, A; Moon, SH; Rodriguez-Barrueco, R; Barsotti, A; Chicas, A; Li, WC; Polotskaia, A; Bissell, MJ; Osborne, TF; Tian, B; Lowe, SW; Silva, JM; Borresen-Dale, AL; Levine, AJ; Bargonetti, J; Prives, C,期刊：Cell, 页码：244-258 , 文章类型： Article，,卷期：2012年148-1-2]
- p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast epithelial cells form sp...
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
[作者：Zhang, WC; Shyh-Chang, N; Yang, H; Rai, A; Umashankar, S; Ma, SM; Soh, BS; Sun, LL; Tai, BC; Nga, ME; Bhakoo, KK; Jayapal, SR; Nichane, M; Yu, Q; Ahmed, DA; Tan, C; Sing, WP; Tam, J; Thirugananam, A; Noghabi, MS; Pang, YH; Ang, HS; Robson, P; Kaldis, P; Soo, RA; Swarup, S; Lim, EH; Lim, B,期刊：Cell, 页码：259-272 , 文章类型： Article，,卷期：2012年148-1-2]
- Identification of the factors critical to the tumor-initiating cell (TIC) state may open new avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is critical for TICs in non-smal...
- Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube
[作者：Balaskas, N; Ribeiro, A; Panovska, J; Dessaud, E; Sasai, N; Page, KM; Briscoe, J; Ribes, V,期刊：Cell, 页码：273-284 , 文章类型： Article，,卷期：2012年148-1-2]
- Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Sonic Hedgehog (Shh) acts a...
- Generation of Chimeric Rhesus Monkeys
[作者：Tachibana, M; Sparman, M; Ramsey, C; Ma, H; Lee, HS; Penedo, MCT; Mitalipov, S,期刊：Cell, 页码：285-295 , 文章类型： Article，,卷期：2012年148-1-2]
- Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the inner cell mass (ICM) a...
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