- A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing
[作者：Mousley, CJ; Yuan, PH; Gaur, NA; Trettin, KD; Nile, AH; Deminoff, SJ; Dewar, BJ; Wolpert, M; Macdonald, JM; Herman, PK; Hinnebusch, AG; Bankaitis, VA,期刊：Cell, 页码：702-715 , 文章类型： Article，,卷期：2012年148-4]
- Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal systems. We demonstrate that Kes1 represents a sterol-regulate...
- Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness
[作者：Raimundo, N; Song, L; Shutt, TE; McKay, SE; Cotney, J; Guan, MX; Gilliland, TC; Hohuan, D; Santos-Sacchi, J; Shadel, GS,期刊：Cell, 页码：716-726 , 文章类型： Article，,卷期：2012年148-4]
- Mitochondrial dysfunction causes poorly understood tissue-specific pathology stemming from primary defects in respiration, coupled with altered reactive oxygen species (ROS), metabolic signaling, and apoptosis. The A1555...
- Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
[作者：Huber, EM; Basler, M; Schwab, R; Heinemeyer, W; Kirk, CJ; Groettrup, M; Groll, M,期刊：Cell, 页码：727-738 , 文章类型： Article，,卷期：2012年148-4]
- Constitutive proteasomes and immunoproteasomes shape the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules by harboring different sets of catalytically active subunits. Here, we p...
- Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model
[作者：Zhang, BC; Kracker, S; Yasuda, T; Casola, S; Vanneman, M; Homig-Holzel, C; Wang, Z; Derudder, E; Li, S; Chakraborty, T; Cotter, SE; Koyama, S; Currie, T; Freeman, GJ; Kutok, JL; Rodig, SJ; Dranoff, G; Rajewsky, K,期刊：Cell, 页码：739-751 , 文章类型： Article，,卷期：2012年148-4]
- B cells infected by Epstein-Barr virus (EBV), a transforming virus endemic in humans, are rapidly cleared by the immune system, but some cells harboring the virus persist for life. Under conditions of immunosuppression, ...
- Local Translation of Extranuclear Lamin B Promotes Axon Maintenance
[作者：Yoon, BC; Jung, H; Dwivedy, A; O'Hare, CM; Zivraj, KH; Holt, CE,期刊：Cell, 页码：752-764 , 文章类型： Article，,卷期：2012年148-4]
- Local protein synthesis plays a key role in regulating stimulus-induced responses in dendrites and axons. Recent genome-wide studies have revealed that thousands of different transcripts reside in these distal neuronal c...
- Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
[作者：Murchison, EP; Schulz-Trieglaff, OB; Ning, ZM; Alexandrov, LB; Bauer, MJ; Fu, BY; Hims, M; Ding, ZH; Ivakhno, S; Stewart, C; Ng, BL; Wong, WD; Aken, B; White, S; Alsop, A; Becq, J; Bignell, GR; Cheetham, RK; Cheng, W; Connor, TR; Cox, AJ; Feng, ZP; Gu, Y; Grocock, RJ; Harris, SR; Khrebtukova, I; Kingsbury, Z; Kowarsky, M; Kreiss, A; Luo, SJ; Marshall, J; McBride, DJ; Murray, L; Pearse, AM; Raine, K; Rasolonjatovo, I; Shaw, R; Tedder, P; Tregidgo, C; Vilella, AJ; Wedge, DC; Woods, GM; Gormley, N; Humphray, S; Schroth, G; Smith, G; Hall, K; Searle, SMJ; Carter, NP; Papenfuss, AT; Futreal, PA; Campbell, PJ; Yang, FT; Bentley, DR; Evers, DJ; Stratton, MR,期刊：Cell, 页码：780-791 , 文章类型： Article，,卷期：2012年148-4]
- The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequen...
- The Majority of Animal Genes Are Required for Wild-Type Fitness
[作者：Ramani, AK; Chuluunbaatar, T; Verster, AJ; Na, H; Vu, V; Pelte, N; Wannissorn, N; Jiao, A; Fraser, AG,期刊：Cell, 页码：792-802 , 文章类型： Article，,卷期：2012年148-4]
- Almost all eukaryotic genes are conserved, suggesting that they have essential functions. However, only a minority of genes have detectable loss-of-function phenotypes in experimental assays, and multiple theories have b...
- Identification of F-actin as the Dynamic Hub in a Microbial-Induced GTPase Polarity Circuit
[作者：Orchard, RC; Kittisopikul, M; Altschuler, SJ; Wu, LF; Suel, GM; Alto, NM,期刊：Cell, 页码：803-815 , 文章类型： Article，,卷期：2012年148-4]
- Polarity in mammalian cells emerges from the assembly of signaling molecules into extensive biochemical interaction networks. Despite their complexity, bacterial pathogens have evolved parsimonious mechanisms to hijack t...
- Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome
[作者：Xie, W; Barr, CL; Kim, A; Yue, F; Lee, AY; Eubanks, J; Dempster, EL; Ren, B,期刊：Cell, 页码：816-831 , 文章类型： Article，,卷期：2012年148-4]
- Differential methylation of the two parental genomes in placental mammals is essential for genomic imprinting and embryogenesis. To systematically study this epigenetic process, we have generated a base-resolution, allel...
|