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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   The Unfolding Story of a Redox Chaperone [作者：Mayer, MP,期刊：Cell, 页码：843-844 , 文章类型： Editorial Material，,卷期：2012年148-5] Oxidative stress, especially in combination with heat stress, poses a life-threatening challenge to many organisms by causing protein misfolding and aggregation. In this issue, Reichmann et al. demonstrate how a destabil... Greasing the Path to BAX/BAK Activation [作者：Hollville, E; Martin, SJ,期刊：Cell, 页码：845-846 , 文章类型： Editorial Material，,卷期：2012年148-5] BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the... DNA-Damage-Induced Differentiation in Hematopoietic Stem Cells [作者：Mandal, PK; Rossi, DJ,期刊：Cell, 页码：847-848 , 文章类型： Editorial Material，,卷期：2012年148-5] Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which... Synaptic Vesicle Distribution by Conveyor Belt [作者：Moughamian, AJ; Holzbaur, ELF,期刊：Cell, 页码：849-851 , 文章类型： Editorial Material，,卷期：2012年148-5] The equal distribution of synaptic vesicles among synapses along the axon is critical for robust neurotransmission. Wong et al. show that the continuous circulation of synaptic vesicles throughout the axon driven by mole... Mechanisms for Insulin Resistance: Common Threads and Missing Links [作者：Samuel, VT; Shulman, GI,期刊：Cell, 页码：852-871 , 文章类型： Review，,卷期：2012年148-5] Insulin resistance is a complex metabolic disorder that defies explanation by a single etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded protein response (UPR) pathway, and innate... Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm [作者：Hou, Y; Song, LT; Zhu, P; Zhang, B; Tao, Y; Xu, X; Li, FQ; Wu, K; Liang, J; Shao, D; Wu, HJ; Ye, XF; Ye, C; Wu, RH; Jian, M; Chen, Y; Xie, W; Zhang, RR; Chen, L; Liu, X; Yao, XT; Zheng, HC; Yu, C; Li, QB; Gong, ZL; Mao, M; Yang, X; Yang, L; Li, JX; Wang, W; Lu, ZH; Gu, N; Laurie, G; Bolund, L; Kristiansen, K; Wang, J; Yang, HM; Li, YR; Zhang, XQ; Wang, J,期刊：Cell, 页码：873-885 , 文章类型： Article，,卷期：2012年148-5] Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene identification. Here, we describe a method for analyzing the cancer genome at a single-cell nucleotide level. To perform our analyse... Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor [作者：Xu, X; Hou, Y; Yin, XY; Bao, L; Tang, AF; Song, LT; Li, FQ; Tsang, S; Wu, K; Wu, HJ; He, WM; Zeng, L; Xing, MJ; Wu, RH; Jiang, H; Liu, X; Cao, DD; Guo, GW; Hu, XD; Gui, YT; Li, ZS; Xie, WY; Sun, XJ; Shi, M; Cai, ZM; Wang, B; Zhong, MM; Li, JX; Lu, ZH; Gu, N; Zhang, XQ; Goodman, L; Bolund, L; Wang, J; Yang, HM; Kristiansen, K; Dean, M; Li, YR; Wang, J,期刊：Cell, 页码：886-895 , 文章类型： Article，,卷期：2012年148-5] Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and has very few mutations that are shared between different patients. To better understand the intratumoral genetics underlying mutations of ccRCC... Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases [作者：Ding, ZH; Wu, CJ; Jaskelioff, M; Ivanova, E; Kost-Alimova, M; Protopopov, A; Chu, GC; Wang, GC; Lu, X; Labrot, ES; Hu, J; Wang, W; Xiao, YH; Zhang, HL; Zhang, JH; Zhang, JF; Gan, BY; Perry, SR; Jiang, S; Li, LR; Horner, JW; Wang, YA; Chin, LD; DePinho, RA,期刊：Cell, 页码：896-907 , 文章类型： Article，,卷期：2012年148-5] To determine the role of telomere dysfunction and telomerase reactivation in generating pro-oncogenic genomic events and in carcinoma progression, an inducible telomerase reverse transcriptase (mTert) allele was crossed ... Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations [作者：Zhang, Y; McCord, RP; Ho, YJ; Lajoie, BR; Hildebrand, DG; Simon, AC; Becker, MS; Alt, FW; Dekker, J,期刊：Cell, 页码：908-921 , 文章类型： Article，,卷期：2012年148-5] The extent to which the three-dimensional organization of the genome contributes to chromosomal translocations is an important question in cancer genomics. We generated a high-resolution Hi-C spatial organization map of ... Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model [作者：Pfingsten, JS; Goodrich, KJ; Taabazuing, C; Ouenzar, F; Chartrand, P; Cech, TR,期刊：Cell, 页码：922-932 , 文章类型： Article，,卷期：2012年148-5] In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere maintenance as acomponent of telomeric chromatin and as an accessory subunit of telomerase. How Ku binding to double-stranded DNA (dsDNA) and to tel... Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis [作者：Huang, YWA; Ruiz, CR; Eyler, ECH; Lin, K; Meffert, MK,期刊：Cell, 页码：933-946 , 文章类型： Article，,卷期：2012年148-5] Control of translation is a fundamental source of regulation in gene expression. The induction of protein synthesis by brain-derived neurotrophic factor (BDNF) critically contributes to enduring modifications of synaptic... Order out of Disorder: Working Cycle of an Intrinsically Unfolded Chaperone [作者：Reichmann, D; Xu, Y; Cremers, CM; Ilbert, M; Mittelman, R; Fitzgerald, MC; Jakob, U,期刊：Cell, 页码：947-957 , 文章类型： Article，,卷期：2012年148-5] The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a ... Spindle Pole Bodies Exploit the Mitotic Exit Network in Metaphase to Drive Their Age-Dependent Segregation [作者：Hotz, M; Leisner, C; Chen, DC; Manatschal, C; Wegleiter, T; Ouellet, J; Lindstrom, D; Gottschling, DE; Vogel, J; Barral, Y,期刊：Cell, 页码：958-972 , 文章类型： Article，,卷期：2012年148-5] Like many asymmetrically dividing cells, budding yeast segregates mitotic spindle poles nonrandomly between mother and daughter cells. During metaphase, the spindle positioning protein Kar9 accumulates asymmetrically, lo... Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis [作者：Wu, CY; Asokan, SB; Berginski, ME; Haynes, EM; Sharpless, NE; Griffith, JD; Gomez, SM; Bear, JE,期刊：Cell, 页码：973-987 , 文章类型： Article，,卷期：2012年148-5] Lamellipodia are sheet-like, leading edge protrusions in firmly adherent cells that contain Arp2/3-generated dendritic actin networks. Although lamellipodia are widely believed to be critical for directional cell motilit... Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis [作者：Chipuk, JE; McStay, GP; Bharti, A; Kuwana, T; Clarke, CJ; Siskind, LJ; Obeid, LM; Green, DR,期刊：Cell, 页码：988-1000 , 文章类型： Article，,卷期：2012年148-5] Mitochondria are functionally and physically associated with heterotypic membranes, yet little is known about how these interactions impact mitochondrial outer-membrane permeabilization (MOMP) and apoptosis. We observed ... A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage [作者：Wang, JW; Sun, Q; Morita, Y; Jiang, H; Gross, A; Lechel, A; Hildner, K; Guachalla, LM; Gompf, A; Hartmann, D; Schambach, A; Wuestefeld, T; Dauch, D; Schrezenmeier, H; Hofmann, WK; Nakauchi, H; Ju, ZY; Kestler, HA; Zender, L; Rudolph, KL,期刊：Cell, 页码：1001-1014 , 文章类型： Article，,卷期：2012年148-5] Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute to cancer protection but may also promote tissue aging. Molecular components that control stem cell responses to DNA damage remain to...