- MicroRNAs in Stress Signaling and Human Disease
[作者：Mendell, JT; Olson, EN,期刊：Cell, 页码：1172-1187 , 文章类型： Review，,卷期：2012年148-6]
- Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellul...
- The Amyloid State of Proteins in Human Diseases
[作者：Eisenberg, D; Jucker, M,期刊：Cell, 页码：1188-1203 , 文章类型： Review，,卷期：2012年148-6]
- Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer's disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of prot...
- Alzheimer Mechanisms and Therapeutic Strategies
[作者：Huang, YD; Mucke, L,期刊：Cell, 页码：1204-1222 , 文章类型： Review，,卷期：2012年148-6]
- There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease h...
- Genetics of Human Cardiovascular Disease
[作者：Kathiresan, S; Srivastava, D,期刊：Cell, 页码：1242-1257 , 文章类型： Review，,卷期：2012年148-6]
- Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease, most of which are heritable. Enormous effort has been invested in understanding the genes and spe...
- The Impact of the Gut Microbiota on Human Health: An Integrative View
[作者：Clemente, JC; Ursell, LK; Parfrey, LW; Knight, R,期刊：Cell, 页码：1258-1270 , 文章类型： Review，,卷期：2012年148-6]
- The human gut harbors diverse microbes that play a fundamental role in the well-being of their host. The constituents of the microbiota-bacteria, viruses, and eukaryotes-have been shown to interact with one another and w...
- Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV
[作者：Goldberg, DE; Siliciano, RF; Jacobs, WR,期刊：Cell, 页码：1271-1283 , 文章类型： Review，,卷期：2012年148-6]
- Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has...
- Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
[作者：Chen, R; Mias, GI; Li-Pook-Than, J; Jiang, LH; Lam, HYK; Chen, R; Miriami, E; Karczewski, KJ; Hariharan, M; Dewey, FE; Cheng, Y; Clark, MJ; Im, H; Habegger, L; Balasubramanian, S; O'Huallachain, M; Dudley, JT; Hillenmeyer, S; Haraksingh, R; Sharon, D; Euskirchen, G; Lacroute, P; Bettinger, K; Boyle, AP; Kasowski, M; Grubert, F; Seki, S; Garcia, M; Whirl-Carrillo, M; Gallardo, M; Blasco, MA; Greenberg, PL; Snyder, P; Klein, TE; Altman, RB; Butte, AJ; Ashley, EA; Gerstein, M; Nadeau, KC; Tang, H; Snyder, M,期刊：Cell, 页码：1293-1307 , 文章类型： Article，,卷期：2012年148-6]
- Personalized medicine is expected to benefit from combining genomic information with regular monitoring of physiological states by multiple high-throughput methods. Here, we present an integrative personal omics profile ...
- Pediatrics: Sequencing the Next Generation
[作者：Gay, LM,期刊：Cell, 页码：1073-1073 , 文章类型： News Item，,卷期：2012年148-6]
- Despite the small sample size that often complicates research into diseases that affect children, recent genome sequencing efforts have made astounding progress in discovering the underlying genetic causes of pediatric d...
- Antibody-Based Immunotherapy of Cancer
[作者：Weiner, LM; Murray, JC; Shuptrine, CW,期刊：Cell, 页码：1081-1084 , 文章类型： Review，,卷期：2012年148-6]
- By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune resp...
- Splice Modulating Therapies for Human Disease
[作者：Spitali, P; Aartsma-Rus, A,期刊：Cell, 页码：1085-1088 , 文章类型： Review，,卷期：2012年148-6]
- Dysregulation of splicing and alternative splicing underlies many genetic and acquired diseases. We present an overview of recent strategies and successes in modulating splicing therapeutically in clinical and preclinica...
|