- Lung Cancer in Never Smokers: A Call to Action
[作者:Rudin, CM; Avila-Tang, E; Samet, JM,期刊:Clinical Cancer Research, 页码:5622-5625 , 文章类型: Article,,卷期:2009年15-18]
- The causative association between tobacco use and lung cancer is a well-established fact. However, lung cancer also occurs, at surprisingly high rates, in lifelong never smokers. In fact, lung cancer in never smokers is ...
- Immunogenicity of the Hu14.18-IL2 Immunocytokine Molecule in Adults With Melanoma and Children With Neuroblastoma
[作者:Hank, JA; Gan, J; Ryu, H; Ostendorf, A; Stauder, MC; Sternberg, A; Albertini, M; Lo, KM; Gillies, SD; Eickhoff, J; Sondel, PM,期刊:Clinical Cancer Research, 页码:5923-5930 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: Immunocytokine (IC) hu14.18-IL2 is a fusion protein of humanized antidisialoganglioside (GD2) antibody (hu14.18) and interleukin (IL)-2. Sixty-one melanoma and neuroblastoma patients received IC in phase I/lb st...
- Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008
[作者:Okunieff, P; Kachnic, LA; Constine, LS; Fuller, CD; Gaspar, LE; Hayes, DF; Hooks, J; Ling, C; Meyskens, FL; Philip, PA; Raben, D; Smalley, SR; Swanson, GP; Teicher, BA; Thomas, CR; Vikram, B; Zelefsky, MJ; Baker, LH,期刊:Clinical Cancer Research, 页码:5663-5670 , 文章类型: Article,,卷期:2009年15-18]
- Strategic planning for the Radiation Therapy Committee of the Southwest Oncology Group (SWOG) is comprehensively evaluated every six years in an effort to maintain a current and relevant scientific focus, and to provide ...
- Wnt Antagonist Gene DKK2 Is Epigenetically Silenced and Inhibits Renal Cancer Progression through Apoptotic and Cell Cycle Pathways
[作者:Hirata, H; Hinoda, Y; Nakajima, K; Kawamoto, K; Kikuno, N; Kawakami, K; Yamamura, S; Ueno, K; Majid, S; Saini, S; Ishii, N; Dahiya, R,期刊:Clinical Cancer Research, 页码:5678-5687 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: Wnt/beta-catenin signaling is involved in renal cancer. DKK2, a Wnt antagonist, is silenced in some cancers, although its function has not been investigated. We hypothesized that DKK2 may be epigenetically silen...
- Interaction of Molecular Markers and Physical Activity on Mortality in Patients with Colon Cancer
[作者:Meyerhardt, JA; Ogino, S; Kirkner, GJ; Chan, AT; Wolpin, B; Ng, K; Nosho, K; Shima, K; Giovannucci, EL; Loda, M; Fuchs, CS,期刊:Clinical Cancer Research, 页码:5931-5936 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exerc...
- A Phase I Trial of Immunotherapy with Lapuleucel-T (APC8024) in Patients with Refractory Metastatic Tumors that Express HER-2/neu
[作者:Peethambaram, PP; Melisko, ME; Rinn, KJ; Alberts, SR; Provost, NM; Jones, LA; Sims, RB; Lin, LRC; Frohlich, MW; Park, JW,期刊:Clinical Cancer Research, 页码:5937-5944 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: This study aimed to evaluate the safety of, immune response induced by, and efficacy of treatment with lapuleucel-T (APC8024) in patients with HER-2/neu-expressing tumors. Lapuleucel-T is an investigational acti...
- Putative Tumor-Suppressive Function of Kruppel-Like Factor 4 in Primary Lung Carcinoma
[作者:Hu, WX; Hofstetter, WL; Li, H; Zhou, YB; He, Y; Pataer, A; Wang, L; Xie, KP; Swisher, SG; Fang, BL,期刊:Clinical Cancer Research, 页码:5688-5695 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: Kruppel-like factor 4(KLF4) is a zinc-finger protein that plays important roles in stem cells and the development of gastric cancers. However, the role of KLF4 in primary lung cancer is unknown. The purpose of t...
- Clinical and Biological Significance of CDK4 Amplification in Well-Differentiated and Dedifferentiated Liposarcomas
[作者:Italiano, A; Bianchini, L; Gjernes, E; Keslair, F; Ranchere-Vince, D; Dumollard, JM; Haudebourg, J; Leroux, A; Mainguene, C; Terrier, P; Chibon, F; Coindre, JM; Pedeutour, F,期刊:Clinical Cancer Research, 页码:5696-5703 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: The MDM2 and HMGA2 genes are consistently amplified in well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) whereas CDK4 is frequently but not always amplified in these tumors. Our goal was to determi...
- Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors
[作者:Samet, JM; Avila-Tang, E; Boffetta, P; Hannan, LM; Olivo-Marston, S; Thun, MJ; Rudin, CM,期刊:Clinical Cancer Research, 页码:5626-5645 , 文章类型: Review,,卷期:2009年15-18]
- More than 161,000 lung cancer deaths are projected to occur in the United States in 2008. Of these, an estimated 10 to 15% will be caused by factors other than active smoking, corresponding to 16,000 to 24,000 deaths ann...
- C-Raf Is Associated with Disease Progression and Cell Proliferation in a Subset of Melanomas
[作者:Jilaveanu, LB; Zito, CR; Aziz, SA; Conrad, PJ; Schmitz, JC; Sznol, M; Camp, RL; Rimm, DL; Kluger, HM,期刊:Clinical Cancer Research, 页码:5704-5713 , 文章类型: Article,,卷期:2009年15-18]
- Purpose: Raf-kinases include three major isoforms. Although the role of B-Raf in melanoma is well established, little is known about C-Raf. We studied effects of C-Raf knockdown in vitro and assessed expression of C-Raf ...
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