- Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
[作者：Bolderson, E; Richard, DJ; Zhou, BBS; Khanna, KK,期刊：Clinical Cancer Research, 页码：6314-6320 , 文章类型： Article，,卷期：2009年15-20]
- Damage to genetic material represents a persistent and ubiquitous threat to genomic stability. Once DNA damage is detected, a multifaceted signaling network is activated that halts the cell cycle, initiates repair, and i...
- Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure
[作者：Nasr, R; Lallemand-Breitenbach, V; Zhu, J; Guillemin, MC; de The, H,期刊：Clinical Cancer Research, 页码：6321-6326 , 文章类型： Article，,卷期：2009年15-20]
- Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosomal translocation that yields the PML/RARA fusion gene. Clinically, besides chemotherapy, two drugs induce clinical remissions: retinoic ...
- Identification of Novel Kinase Targets for the Treatment of Estrogen Receptor-Negative Breast Cancer
[作者：Speers, C; Tsimelzon, A; Sexton, K; Herrick, AM; Gutierrez, C; Culhane, A; Quackenbush, J; Hilsenbeck, S; Chang, J; Brown, P,期刊：Clinical Cancer Research, 页码：6327-6340 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Previous gene expression profiling studies of breast cancer have focused on the entire genome to identify genes differentially expressed between estrogen receptor (ER) a-positive and ER-a-negative cancers.Experi...
- Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+T-Cell Infiltration and Survival of Patients with Cervical Carcinoma
[作者：Karim, R; Jordanova, ES; Piersma, SJ; Kenter, GG; Chen, LP; Boer, JM; Melief, CJM; van der Burg, SH,期刊：Clinical Cancer Research, 页码：6341-6347 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: The interaction between programmed cell death 1 (PD-1), expressed by activated effector or regulatory T cells, and B7-H1 (PD-L1) and B7-DC (PD-L2) results in the inhibition of T-cell function. The aim of this st...
- Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer
[作者：Mandapathil, M; Szczepanski, MJ; Szajnik, M; Ren, J; Lenzner, DE; Jackson, EK; Gorelik, E; Lang, S; Johnson, JT; Whiteside, TL,期刊：Clinical Cancer Research, 页码：6348-6357 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Regulatory T cell (Treg) frequency and activity are increased in cancer patients and play a major role in tumor escape. Although disease progression is favored by the presence of Treg, mechanisms used by Treg to...
- Comparative Impact of Trastuzumab and Cyclophosphamide on HER-2-Positive Human Breast Cancer Xenografts
[作者：Francia, G; Man, S; Lee, CJ; Lee, CR; Xu, P; Mossoba, ME; Emmenegger, U; Medin, JA; Kerbel, RS,期刊：Clinical Cancer Research, 页码：6358-6366 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Metronomic chemotherapy is a minimally toxic and frequently effective new treatment strategy that is beginning to show promising phase 11 clinical trial results, particularly for metastatic breast cancer when co...
- Oral Poly(ADP-Ribose) Polymerase-1 Inhibitor BSI-401 Has Antitumor Activity and Synergizes with Oxaliplatin against Pancreatic Cancer, Preventing Acute Neurotoxicity
[作者：Melisi, D; Ossovskaya, V; Zhu, CH; Rosa, R; Ling, JH; Dougherty, PM; Sherman, BM; Abbruzzese, JL; Chiao, PJ,期刊：Clinical Cancer Research, 页码：6367-6377 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Development of novel agents and drug combinations are urgently needed for treatment of pancreatic cancer. Oxaliplatin belongs to an important class of DNA-damaging organoplatinum agents, useful in pancreatic can...
- Clinical Predictors and Algorithm for the Genetic Diagnosis of Pheochromocytoma Patients
[作者：Erlic, Z; Rybicki, L; Peczkowska, M; Golcher, H; Kann, PH; Brauckhoff, M; Mussig, K; Muresan, M; Schaffler, A; Reisch, N; Schott, M; Fassnacht, M; Opocher, G; Klose, S; Fottner, C; Forrer, F; Plockinger, U; Petersenn, S; Zabolotny, D; Kollukch, O; Yaremchuk, S; Januszewicz, A; Waiz, MK; Eng, C; Neumann, HPH,期刊：Clinical Cancer Research, 页码：6378-6385 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Six pheochromocytoma susceptibility genes causing distinct syndromes have been identified; approximately one of three of all pheochromocytoma patients carry a predisposing germline mutation. When four major gene...
- An Embryonic Stem Cell-Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma
[作者：Hassan, KA; Chen, G; Kalemkerian, GP; Wicha, MS; Beer, DG,期刊：Clinical Cancer Research, 页码：6386-6390 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: An embryonic stem cell (ESC) profile correlates with poorly differentiated breast, bladder, and glioma cancers. In this article, we assess the correlation between the ESC profile and clinical variables in lung c...
- Gender Disparities in Metastatic Colorectal Cancer Survival
[作者：Hendifar, A; Yang, DY; Lenz, F; Lurje, G; Pohl, A; Lenz, C; Ning, Y; Zhang, W; Lenz, HJ,期刊：Clinical Cancer Research, 页码：6391-6397 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Previous studies have shown that estrogen prevents colon cancer in postmenopausal women, indicating a role in colorectal cancer carcinogenesis and tumor progression. We investigated the interactions between sex,...
- Overexpression of Prostate-Specific TMPRSS2(exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer
[作者：Hermans, KG; Boormans, JL; Gasi, D; van Leenders, GJHL; Jenster, G; Verhagen, PCMS; Trapman, J,期刊：Clinical Cancer Research, 页码：6398-6403 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: To gain insight in the mechanism and clinical relevance of TMPRSS2-ERG expression in prostate cancer, we determined the specific characteristics of fusion transcripts starting at TMPRSS2 exon 1 and at a more ups...
- Loss of SNF5 Expression Correlates with Poor Patient Survival in Melanoma
[作者：Lin, H; Wong, RPC; Martinka, M; Li, G,期刊：Clinical Cancer Research, 页码：6404-6411 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Aberrant expression of SWI/SNF chromatin remodeling complex is involved in cancer development. The tumor suppressor SNF5, the core subunit of SWI/SNF complex, has been shown to regulate cell differentiation, cel...
- Lymphocytic Reaction to Colorectal Cancer Is Associated with Longer Survival, Independent of Lymph Node Count, Microsatellite Instability, and CpG Island Methylator Phenotype
[作者：Ogino, S; Nosho, K; Irahara, N; Meyerhardt, JA; Baba, Y; Shima, K; Glickman, JN; Ferrone, CR; Mino-Kenudson, M; Tanaka, N; Dranoff, G; Giovannucci, EL; Fuchs, CS,期刊：Clinical Cancer Research, 页码：6412-6420 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Host immune response to tumor may be an important prognostic factor for colon cancer patients. However, little is known on prognostic significance of histopathologic lymphoid reaction to tumor, independent of th...
- Recombinant Peptides as Biomarkers for Tumor Response to Molecular Targeted Therapy
[作者：Passarella, RJ; Zhou, L; Phillips, JG; Wu, HM; Hallahan, DE; Diaz, R,期刊：Clinical Cancer Research, 页码：6421-6429 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Phage display technology can be used to identify peptide sequences that bind rapidly and specifically to tumors responding to sunitinib therapy. These pepticles may help to address problems with current methods ...
- Polysomy for Chromosomes 1 and 19 Predicts Earlier Recurrence in Anaplastic Oligodendrogliomas with Concurrent 1p/19q Loss
[作者：Snuderl, M; Eichler, AF; Ligon, KL; Vu, QU; Silver, M; Betensky, RA; Ligon, AH; Wen, PY; Louis, DN; Iafrate, AJ,期刊：Clinical Cancer Research, 页码：6430-6437 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: Loss of chromosome arms 1 p and 19q is a molecular feature of oligodendroglial tumors characterized by responsiveness to chemotherapy and a favorable prognosis. The purpose of this study was to evaluate the prog...
- DNA Ploidy Cytometry Testing for Cervical Cancer Screening in China (DNACIC Trial): a Prospective Randomized, Controlled Trial
[作者：Tong, H; Shen, R; Wang, ZM; Kan, YJ; Wang, YQ; Li, FS; Wang, FZ; Yang, J; Guo, XR,期刊：Clinical Cancer Research, 页码：6438-6445 , 文章类型： Article，,卷期：2009年15-20]
- Purpose: This randomized, controlled trial was designed to determine whether the DNA cytometry testing is superior to the conventional cytologic testing for mass cervical cancer screening.Experimental Design: After appro...
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