- Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging
[作者：O'Connor, JPB; Carano, RAD; Clamp, AR; Ross, J; Ho, CCK; Jackson, A; Parker, GJM; Rose, CJ; Peale, FV; Friesenhahn, M; Mitchell, CL; Watson, Y; Roberts, C; Hope, L; Cheung, S; Reslan, HB; Go, MAT; Pacheco, GJ; Wu, XM; Cao, TC; Ross, S; Buonaccorsi, GA; Davies, K; Hasan, J; Thornton, P; del Puerto, O; Ferrara, N; van Bruggen, N; Jayson, GC,期刊：Clinical Cancer Research, 页码：6674-6682 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Little is known concerning the onset, duration, and magnitude of direct therapeutic effects of anti-vascular endothelial growth factor (VEGF) therapies. Such knowledge would help guide the rational development o...
- Prognostic Significance of Molecular Markers and Extent of Resection in Primary Glioblastoma Patients
[作者：Felsberg, J; Rapp, M; Loeser, S; Fimmers, R; Stummer, W; Goeppert, M; Steiger, HJ; Friedensdorf, B; Reifenberger, G; Sabel, MC,期刊：Clinical Cancer Research, 页码：6683-6693 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Despite multimodal aggressive treatment glioblastoma patients still face a rather poor prognosis. Recent data indicate that certain molecular markers, in particular MGMT promoter hypermethylation, are associated...
- The p53 Family Protein p73 Provides New Insights into Cancer Chemosensitivity and Targeting
[作者：Lunghi, P; Costanzo, A; Mazzera, L; Rizzoli, V; Levrero, M; Bonati, A,期刊：Clinical Cancer Research, 页码：6495-6502 , 文章类型： Review，,卷期：2009年15-21]
- The p53 tumor suppressor is part of a small family of related proteins that includes two other members, p73 and p63. Interest in the p53 family members, their functions and their complex interactions and regulation, has ...
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
[作者：Dang, CV; Le, A; Gao, P,期刊：Clinical Cancer Research, 页码：6479-6483 , 文章类型： Article，,卷期：2009年15-21]
- Although cancers have altered glucose metabolism, termed the Warburg effect, which describes the increased uptake and conversion of glucose to lactate by cancer cells under adequate oxygen tension, changes in the metabol...
- Circulating Mesothelin Protein and Cellular Antimesothelin Immunity in Patients with Pancreatic Cancer
[作者：Johnston, FM; Tan, MCB; Tan, BR; Porembka, MR; Brunt, EM; Linehan, DC; Simon, PO; Plambeck-Suess, S; Eberlein, TJ; Hellstrom, KE; Hellstrom, I; Hawkins, WG; Goedegebuure, P,期刊：Clinical Cancer Research, 页码：6511-6518 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Mesothelin is a glycoprotein expressed on normal mesothelial cells and is overexpressed in several histologic types of tumors including pancreatic adenocarcinomas. A soluble form of mesothelin has been detected ...
- Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells
[作者：Warner, SL; Stephens, BJ; Nwokenkwo, S; Hostetter, G; Sugeng, A; Hidalgo, M; Trent, JM; Han, HY; Von Hoff, DD,期刊：Clinical Cancer Research, 页码：6519-6528 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: The targeting protein for XkIp2 (TPX2) has recently gained attention as a putative oncogene possibly amplified in several human malignancies, including pancreatic adenocarcinoma. In this work, we sought to evalu...
- Cross-Talk between Estrogen Receptor and Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma
[作者：Egloff, AM; Rothstein, ME; Seethala, R; Siegfried, JM; Grandis, JR; Stabile, LP,期刊：Clinical Cancer Research, 页码：6529-6540 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: This study aimed to characterize estrogen receptor expression and signaling in head and neck squamous cell carcinoma (HNSCC) cell lines and patient tissues, and to evaluate estrogen receptor and epidermal growth...
- Genomic and Expression Profiling of Glioblastoma Stem Cell-Like Spheroid Cultures Identifies Novel Tumor-Relevant Genes Associated with Survival
[作者：Ernst, A; Hofmann, S; Ahmadi, R; Becker, N; Korshunov, A; Engel, F; Hartmann, C; Felsberg, J; Sabe, M; Peterziel, H; Durchdewald, M; Hess, J; Barbus, S; Campos, B; Starzinski-Powitz, A; Unterberg, A; Reifenberger, G; Lichter, P; Herold-Mende, C; Radlwimmer, B,期刊：Clinical Cancer Research, 页码：6541-6550 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Glioblastoma spheroid cultures are enriched in tumor stem-like cells and therefore may be more representative of the respective primary tumors than conventional monolayer cultures. We exploited the glioma sphero...
- Systemic Inhibition of Transforming Growth Factor-beta in Glioma-Bearing Mice Improves the Therapeutic Efficacy of Glioma-Associated Antigen Peptide Vaccines
[作者：Ueda, R; Fujita, M; Zhu, XM; Sasaki, K; Kastenhuber, ER; Kohanbash, G; McDonald, HA; Harper, J; Lonning, S; Okada, H,期刊：Clinical Cancer Research, 页码：6551-6559 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: A variety of cancers, including malignant gliomas, overexpress transforming growth factor-beta (TGF-beta), which helps tumors evade effective immune surveillance through a variety of mechanisms, including inhibi...
- Synergistic Enhancement of CD8(+) T Cell-Mediated Tumor Vaccine Efficacy by an Anti-Transforming Growth Factor-beta Monoclonal Antibody
[作者：Terabe, M; Ambrosino, E; Takaku, S; O'Konek, JJ; Venzon, D; Lonnin, S; McPherson, JM; Berzofsky, JA,期刊：Clinical Cancer Research, 页码：6560-6569 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Transforming growth factor-beta (TGF-beta) is an immunosuppressive cytokine, having direct suppressive activity against conventional CD4(+) and CD8(+)T cells and natural killer cells, thereby inhibiting tumor im...
- Mammary-Derived Growth Inhibitor Alters Traffic of EGFR and Induces a Novel Form of Cetuximab Resistance
[作者：Nevo, J; Mattila, E; Pellinen, T; Yamamoto, DL; Sara, H; Iljin, K; Kallioniemi, O; Bono, P; Heikkila, P; Joensuu, H; Warri, A; Ivaska, J,期刊：Clinical Cancer Research, 页码：6570-6581 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Only few predictive factors for the clinical activity of anti-epidermal growth factor receptor (EGFR) therapy are available. Mammary-derived growth inhibitor (MDGI) is a small cytosolic protein suggested to play...
- Rituximab-Mediated Cell Signaling and Chemo/Immuno-sensitization of Drug-Resistant B-NHL Is Independent of Its Fc Functions
[作者：Vega, MI; Huerta-Yepez, S; Martinez-Paniagua, M; Martinez-Miguel, B; Hernandez-Pando, R; Gonzalez-Bonilla, CR; Chinn, P; Hanna, N; Hariharan, K; Jazirehi, AR; Bonavida, B,期刊：Clinical Cancer Research, 页码：6582-6594 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: Rituximab [chimeric anti-CD20 monoclonal antibody], alone or combined with chemotherapy, is used in the treatment of non-Hodgkin's lymphoma (NHL). Rituximab binds to CD20 and inhibits intracellular survival/grow...
- Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter
[作者：Peerlinck, I; Merron, A; Baril, P; Conchon, S; Martin-Duque, P; Hindorf, C; Burnet, J; Quintanilla, M; Hingorani, M; Iggo, R; Lemoine, NR; Harrington, K; Vassaux, G,期刊：Clinical Cancer Research, 页码：6595-6601 , 文章类型： Article，,卷期：2009年15-21]
- Purpose: The Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter gene for molecular imaging of viral biodistribution and as a therapeutic pr...
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