- Tumor-Derived Tissue Factor-Bearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy
[作者：Zwicker, JI; Liebman, HA; Neuberg, D; Lacroix, R; Bauer, KA; Furie, BC; Furie, B,期刊：Clinical Cancer Research, 页码：6830-6840 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Despite the strong association between malignant disease and thromboembolic disorders, the molecular and cellular basis of this relationship remains uncertain. We evaluated the hypothesis that tumor-derived tiss...
- JNJ-26481585, a Novel "Second-Generation" Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
[作者：Arts, J; King, P; Marien, A; Floren, W; Belien, A; Janssen, L; Pilatte, I; Roux, B; Decrane, L; Gilissen, R; Hickson, I; Vreys, V; Cox, E; Bol, K; Talloen, W; Goris, I; Andries, L; Du Jardin, M; Janicot, M; Page, M; van Emelen, K; Angibaud, P,期刊：Clinical Cancer Research, 页码：6841-6851 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited. Most HDAC inhibitors in ...
- Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer
[作者：Byers, LA; Sen, B; Saigal, B; Diao, LX; Wang, J; Nanjundan, M; Cascone, T; Mills, GB; Heymach, JV; Johnson, FM,期刊：Clinical Cancer Research, 页码：6852-6861 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Signal transducer and activator of transcription-3 (STAT3) is downstream of growth factor and cytokine receptors, and regulates key oncogenic pathways in non-small cell lung cancer (NSCLC). Activation of STAT3 b...
- Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance
[作者：Guo, TH; Hajdu, M; Agaram, NP; Shinoda, H; Veach, D; Clarkson, BD; Maki, RG; Singer, S; DeMatteo, RP; Besmer, P; Antonescu, CR,期刊：Clinical Cancer Research, 页码：6862-6870 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Although tyrosine kinase inhibitors have improved survival in advanced gastrointestinal stromal tumor (GIST), complete response is rare and most patients eventually fail the first-line treatment with imatinib. S...
- Production of Interferon-gamma-Inducible Protein-10 and Its Role as an Autocrine Invasion Factor in Nasal Natural Killer/T-Cell Lymphoma Cells
[作者：Moriai, S; Takahara, M; Ogino, T; Nagato, T; Kishibe, K; Ishii, H; Katayama, A; Shimizu, N; Harabuchi, Y,期刊：Clinical Cancer Research, 页码：6771-6779 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Nasal natural killer (NK)/T-cell lymphoma is associated with Epstein-Barr virus and has poor prognosis because of local invasion and/or multiple dissemination. Recently, the role of chemokines/chemokine receptor...
- Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of Transforming Growth Factor-alpha and PTGS2
[作者：Dougherty, U; Cerasi, D; Taylor, I; Kocherginsky, M; Tekin, U; Badal, S; Aluri, L; Sehdev, A; Cerda, S; Mustafi, R; Delgado, J; Joseph, L; Zhu, HY; Hart, J; Threadgill, D; Fichera, A; Bissonnette, M,期刊：Clinical Cancer Research, 页码：6780-6789 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Colon cancer is a major cause of cancer deaths. Dietary factors contribute substantially to the risk of this malignancy. Western-style diets promote development of azoxymethane-induced colon cancer. Although we ...
- Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
[作者：Girard, N; Shen, RL; Guo, TH; Zakowski, MF; Heguy, A; Riely, GJ; Huang, J; Lau, C; Lash, AE; Ladanyi, M; Viale, A; Antonescu, CR; Travis, WD; Rusch, VW; Kris, MG; Pao, W,期刊：Clinical Cancer Research, 页码：6790-6799 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Thymomas and thymic carcinomas are rare intrathoracic malignancies that can be invasive and refractory to conventional treatment. Because these tumors both originate from the thymus, they are often grouped toget...
- Subsets of Very Low Risk Wilms Tumor Show Distinctive Gene Expression, Histologic, and Clinical Features
[作者：Sredni, ST; Gadd, S; Huang, CC; Breslow, N; Grundy, P; Green, DM; Dome, JS; Shamberger, RC; Beckwith, JB; Perlman, EJ,期刊：Clinical Cancer Research, 页码：6800-6809 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Recent studies suggest that children <24 months with stage I favorable histology Wilms tumors <550 g [very low risk Wilms tumors (VLRWT)] have an excellent prognosis when treated with nephrectomy only, without a...
- Deregulated GSK3 beta Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase
[作者：Mai, W; Kawakami, K; Shakoori, A; Kyo, S; Miyashita, K; Yokoi, K; Jin, MJ; Shimasaki, T; Motoo, Y; Minamoto, T,期刊：Clinical Cancer Research, 页码：6810-6819 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Glycogen synthase kinase-3 beta (GSK3 beta) regulates multiple cell signaling pathways and has been implicated in glucose intolerance, neurodegenerative disorders, and inflammation. We investigated the expressio...
- Snail Promotes CXCR2 Ligand-Dependent Tumor Progression in Non-Small Cell Lung Carcinoma
[作者：Yanagawa, J; Walser, TC; Zhu, LX; Hong, LS; Fishbein, MC; Mah, V; Chia, D; Goodglick, L; Elashoff, DA; Luo, J; Magyar, CE; Dohadwala, M; Lee, JM; St John, MA; Strieter, RM; Sharma, S; Dubinett, SM,期刊：Clinical Cancer Research, 页码：6820-6829 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: As a transcriptional repressor of E-cadherin, Snail has predominantly been associated with epithelial-mesenchymal transition, invasion, and metastasis. However, other important Snail-dependent malignant phenotyp...
- A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies
[作者：O'Connor, OA; Stewart, AK; Vallone, M; Molineaux, CJ; Kunkel, LA; Gerecitano, JF; Orlowski, RZ,期刊：Clinical Cancer Research, 页码：7085-7091 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Carfilzomib (formerly PR-171) is a novel proteasome inhibitor of the epoxyketone class that is selective and structurally distinct from bortezomib. Proteasome inhibition by carfilzomib is mechanistically irrever...
- The Neuropharmacokinetics of Temozolomide in Patients with Resectable Brain Tumors: Potential Implications for the Current Approach to Chemoradiation
[作者：Portnow, J; Badie, B; Chen, M; Liu, A; Blanchard, S; Synold, TW,期刊：Clinical Cancer Research, 页码：7092-7098 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Intracerebral microdialysis (ICMD) is an accepted method for monitoring changes in neurochemistry from acute brain injury. The goal of this pilot study was to determine the feasibility of using ICMD to examine t...
- Phase II Study of Androgen Synthesis Inhibition with Ketoconazole, Hydrocortisone, and Dutasteride in Asymptomatic Castration-Resistant Prostate Cancer
[作者：Taplin, ME; Regan, MM; Ko, YJ; Bubley, GJ; Duggan, SE; Werner, L; Beer, TM; Ryan, CW; Mathew, P; Tu, SM; Denmeade, SR; Oh, WK; Sartor, O; Mantzoros, CS; Rittmaster, R; Kantoff, PW; Balk, SP,期刊：Clinical Cancer Research, 页码：7099-7105 , 文章类型： Article，,卷期：2009年15-22]
- Purpose: Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to ...
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