- Superior Antitumor Activity of SAR3419 to Rituximab in Xenograft Models for Non-Hodgkin's Lymphoma
[作者：Al-Katib, AM; Aboukameel, A; Mohammad, R; Bissery, MC; Zuany-Amorim, C,期刊：Clinical Cancer Research, 页码：4038-4045 , 文章类型： Proceedings Paper，,卷期：2009年15-12]
- Purpose: To investigate the activity of SAR3419, a novel humanized anti-CD19 antibody (huB4), conjugated to a cytotoxic maytansine derivative N-2'-deacetyI-N-2'-(4-mercapto4-methyl-1-oxopentyl) maytansine, in preclinical...
- CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
[作者：Bao, RD; Lai, CJ; Qu, H; Wang, DG; Yin, L; Zifcak, B; Atoyan, R; Wang, J; Samson, M; Forrester, J; DellaRocca, S; Xu, GX; Tao, X; Zhai, HX; Cai, X; Qian, CG,期刊：Clinical Cancer Research, 页码：4046-4057 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: We designed and synthesized CUDC-305, an HSP90 inhibitor of the novel imidazopyridine class. Here, we report its unique pharmacologic properties and antitumor activities in a variety of tumor types. Experimental...
- High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model
[作者：Floris, G; Debiec-Rychter, M; Sciot, R; Stefan, C; Fieuws, S; Machiels, K; Atadja, P; Wozniak, A; Faa, G; Schoffski, P,期刊：Clinical Cancer Research, 页码：4066-4076 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: Histone deacetylase inhibitors have emerged as potent anticancer compounds. Using a nude-mouse xenograft model, for the first time we evaluated the response of human gastrointestinal stromal tumors (GIST) carryi...
- Restoration of p53 Pathway by Nutlin-3 Induces Cell Cycle Arrest and Apoptosis in Human Rhabdomyosarcoma Cells
[作者：Miyachi, M; Kakazu, N; Yagyu, S; Katsumi, Y; Tsubai-Shimizu, S; Kikuchi, K; Tsuchiya, K; Iehara, T; Hosoi, H,期刊：Clinical Cancer Research, 页码：4077-4084 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: Seventy to eighty percent of rhabdomyosarcoma (RMS) tumors retain wild-type p53. The tumor suppressor p53 plays a central role in inducing cell cycle arrest or apoptosis in response to various stresses. p53 prot...
- Impaired STAT Phosphorylation in T Cells from Melanoma Patients in Response to IL-2: Association with Clinical Stage
[作者：Mortarini, R; Vegetti, C; Molla, A; Arienti, F; Ravagnani, F; Maurichi, A; Patuzzo, R; Santinami, M; Anichini, A,期刊：Clinical Cancer Research, 页码：4085-4094 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: To assess the extent of signal transducer and activator of transcription (STAT) activation in response to interleukin 2 (IL-2) in melanoma patients' T cells, along with clinical stage of tumor progression. Exper...
- Targeting GIPC/Synectin in Pancreatic Cancer Inhibits Tumor Growth
[作者：Muders, MH; Vohra, PK; Dutta, SK; Wang, E; Ikeda, Y; Wang, L; Udugamasooriya, DG; Memic, A; Rupashinghe, CN; Baretton, GB; Aust, DE; Langer, S; Dam, K; Simons, M; Spaller, MR; Mukhopadhyay, D,期刊：Clinical Cancer Research, 页码：4095-4103 , 文章类型： Proceedings Paper，,卷期：2009年15-12]
- Purpose: Various studies have shown the importance of the GAIP interacting protein, COOH-terminus (GIPC, also known as Synectin) as a central adaptor molecule in different signaling pathways and as an important mediator ...
- MMP11: A Novel Target Antigen for Cancer Immunotherapy
[作者：Peruzzi, D; Mori, F; Conforti, A; Lazzaro, D; De Rinaldis, E; Ciliberto, G; La Monica, N; Aurisicchio, L,期刊：Clinical Cancer Research, 页码：4104-4113 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that mediate numerous physiologic and pathologic processes, including matrix degradation, tissue remodeling, inflammation, and tumor metastasis. ...
- Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration
[作者：Schwartz, AL; Malgor, R; Dickerson, E; Weeraratna, AT; Slominski, A; Wortsman, J; Harii, N; Kohn, AD; Moon, RT; Schwartz, FL; Goetz, DJ; Kohn, LD; McCall, KD,期刊：Clinical Cancer Research, 页码：4114-4122 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: To evaluate whether (a) Wnt5a expression in pancreatic cancer and malignant melanoma cells might be associated with constitutive levels of Toll-like receptor 3 (TLR3) and/or TLR3 signaling; (b) phenylmethimazole...
- Extranuclear Coactivator Signaling Confers Insensitivity to Tamoxifen
[作者：Kumar, R; Zhang, H; Holm, C; Vadlamudi, RK; Landberg, G; Rayala, SK,期刊：Clinical Cancer Research, 页码：4123-4130 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: Tamoxifen is one of many standard therapeutic options currently available for estrogen receptor-a-positive breast cancer patients. Emerging data have suggested that levels of estrogen receptor coregulatory prote...
- Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer
[作者：Matthews, K; Noker, PE; Tian, BH; Grimes, SD; Fulton, R; Schweikart, K; Harris, R; Aurigemma, R; Wang, MH; Barnes, MN; Siegal, GP; Hemminki, A; Zinn, K; Curiel, DT; Alvarez, RD,期刊：Clinical Cancer Research, 页码：4131-4137 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: The purpose of this study was to evaluate the biodistribution and toxicity of Ad5.SSTR/TK.RGD, an infectivity-enhanced adenovirus expressing a therapeutic suicide gene and somatostatin receptor type 2 (for nonin...
- Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic Cancer
[作者：Rajeshkumar, NV; Tan, AC; De Oliveira, E; Womack, C; Wombwell, H; Morgan, S; Warren, MV; Walker, J; Green, TP; Jimeno, A; Messersmith, WA; Hidalgo, M,期刊：Clinical Cancer Research, 页码：4138-4146 , 文章类型： Proceedings Paper，,卷期：2009年15-12]
- Purpose: To determine the efficacy of AZD0530, an orally active small molecule Src inhibitor, in human pancreatic cancer xenografts and to seek biomarkers predictive of activity. Experimental Design: Sixteen patient-deri...
- Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab
[作者：Yao, E; Zhou, W; Lee-Hoeflich, ST; Truong, T; Haverty, PM; Eastham-Anderson, J; Lewin-Koh, N; Gunter, B; Belvin, M; Murray, LJ; Friedman, LS; Sliwkowski, MX; Hoeflich, KP,期刊：Clinical Cancer Research, 页码：4147-4156 , 文章类型： Article，,卷期：2009年15-12]
- Purpose: Oncogenic activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is prevalent in breast cancer and has been associated with resistance to HER2 inhibitors in the clinic. We therefore investigate...
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