- Activation of p38 Mitogen-Activated Protein Kinase Drives Dendritic Cells to Become Tolerogenic in Ret Transgenic Mice Spontaneously Developing Melanoma
[作者：Zhao, F; Falk, C; Osen, W; Kato, M; Schadendorf, D; Umansky, V,期刊：Clinical Cancer Research, 页码：4382-4390 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: The purpose of the study was to investigate signaling molecules involved in the acquisition of tolerogenic properties by dendritic cells (DC) in ret transgenic mice with spontaneous melanoma progression and to t...
- Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity
[作者：Candolfi, M; Yagiz, K; Foulad, D; Alzadeh, GE; Tesarfreund, M; Muhammad, AKMG; Puntel, M; Kroeger, KM; Liu, CY; Lee, S; Curtin, JF; King, GD; Lerner, J; Sato, K; Mineharu, Y; Xiong, WD; Lowenstein, PR; Castro, MG,期刊：Clinical Cancer Research, 页码：4401-4414 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: In preparation for a phase I clinical trial using a combined cytotoxic/immunotherapeutic strategy with adenoviruses (Ad) expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we t...
- Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
[作者：Rossi, D; Spina, V; Cerri, M; Rasi, S; Deambrogi, C; De Paoli, L; Laurenti, L; Maffei, R; Forconi, F; Bertoni, F; Zucca, E; Agostinelli, C; Cabras, A; Lucioni, M; Martini, M; Magni, M; Deaglio, S; Ladetto, M; Nomdedeu, JF; Besson, C; Ramponi, A; Canzonieri, V; Paulli, M; Marasca, R; Larocca, LM; Carbone, A; Pileri, SA; Gattei, V; Gaidano, G,期刊：Clinical Cancer Research, 页码：4415-4422 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR)...
- Expression of the Receptor Tyrosine Kinase EphA2 Is Increased in Smokers and Predicts Poor Survival in Non-Small Cell Lung Cancer
[作者：Brannan, JM; Dong, WL; Prudkin, L; Behrens, C; Lotan, R; Bekele, BN; Wistuba, I; Johnson, FM,期刊：Clinical Cancer Research, 页码：4423-4430 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Up-regulation of the receptor tyrosine kinase EphA2 has been shown in several epithelial cancers. Epidermal growth factor receptor (EGFR) and K-Ras have been reported to regulate EphA2 in several in vitro models...
- A Cohort Study of Cyclin D1 Expression and Prognosis in 602 Colon Cancer Cases
[作者：Ogino, S; Nosho, K; Irahara, N; Kure, S; Shima, K; Baba, Y; Toyoda, S; Chen, L; Giovannucci, EL; Meyerhardt, JA; Fuchs, CS,期刊：Clinical Cancer Research, 页码：4431-4438 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Cyclin D1 and cyclin-dependent kinases (CDK) are commonly activated in colorectal cancer. The activity of cyclin D1 can be blocked by CDK inhibitors, including p27 (CDKN1B) and p21 (CDKN1A, which is induced by p...
- Proposal and Validation of Prognostic Scoring Systems for IgG and IgA Monoclonal Gammopathies of Undetermined Significance
[作者：Rossi, F; Petrucci, M; Guffanti, A; Marcheselli, L; Rossi, D; Callea, V; Vincenzo, F; De Muro, M; Baraldi, A; Villani, O; Musto, P; Bacigalupo, A; Gaidano, G; Avvisati, G; Goldaniga, M; DePaoli, L; Baldini, L,期刊：Clinical Cancer Research, 页码：4439-4445 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: The presenting clinico-hematologic features of 1,283 patients with IgG and IgA monoclonal gammopathies of undetermined significance (MGUS) were correlated with the frequency of evolution into multiple myeloma (M...
- Electrochemical Sensor for Multiplex Biomarkers Detection
[作者：Wei, F; Patel, P; Liao, W; Chaudhry, K; Zhang, L; Arellano-Garcia, M; Hu, S; Elashoff, D; Zhou, H; Shukla, S; Shah, F; Ho, CM; Wong, DT,期刊：Clinical Cancer Research, 页码：4446-4452 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Multiplexing assay of biomarkers at the point-of-care is an elusive goal for molecular diagnostics. Experimental Design: Here, we report an electrochemical (EC) sensor for oral cancer detection based on the simu...
- Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
[作者：Cha, EJ; Noh, SJ; Kwon, KS; Kim, CY; Park, BH; Park, HS; Lee, H; Chung, MJ; Kang, MJ; Lee, DG; Moon, WS; Jang, KY,期刊：Clinical Cancer Research, 页码：4453-4459 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers. We therefore investigated the expression levels of SIRT1 and its negative re...
- Enhanced Systemic Immune Reactivity to a Basal Cell Carcinoma Associated Antigen Following Photodynamic Therapy
[作者：Kabingu, E; Oseroff, AR; Wilding, GE; Gollnick, SO,期刊：Clinical Cancer Research, 页码：4460-4466 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Numerous preclinical studies have shown that local photodynamic therapy (PDT) of tumors enhances systemic antitumor immunity. However, other than single-case and anecdotal reports, this phenomenon has not been e...
- Vaccination with Recombinant NY-ESO-1 Protein Elicits Immunodominant HLA-DR52b-restricted CD4(+) T Cell Responses with a Conserved T Cell Receptor Repertoire
[作者：Bioley, G; Dousset, C; Yeh, A; Dupont, B; Bhardwaj, N; Mears, G; Old, LJ; Ayyoub, M; Valmori, D,期刊：Clinical Cancer Research, 页码：4467-4474 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: ESO is a tumor-specific antigen with wide expression in human tumors of different histologic types and remarkable spontaneous immunogenicity. We have previously shown that specific T(H)1 and antibody responses c...
- Phase I Pharmacokinetic and Pharmacodynamic Study of Carboplatin and Topotecan Administered Intravenously Every 28 Days to Patients with Malignant Solid Tumors
[作者：Boss, DS; Siegel-Lakhai, WS; van Egmond-Schoemaker, NE; Pluim, D; Rosing, H; Huinink, WWT; Beijnen, JH; Schellens, JHM,期刊：Clinical Cancer Research, 页码：4475-4483 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Preclinical studies have shown that the combination of topotecan and carboplatin is synergistic. To evaluate the schedule dependency of this interaction, the following phase I trial was designed to determine the...
- Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non-Small Cell Lung Cancer with EGFR Mutations
[作者：Morita, S; Okamoto, I; Kobayashi, K; Yamazaki, K; Asahina, H; Inoue, A; Hagiwara, K; Sunaga, N; Yanagitani, N; Hida, T; Yoshida, K; Hirashima, T; Yasumoto, K; Sugio, K; Mitsudomi, T; Fukuoka, M; Nukiwa, T,期刊：Clinical Cancer Research, 页码：4493-4498 , 文章类型： Article，,卷期：2009年15-13]
- Purpose: Somatic mutations of the epidermal growth factor receptor (EGFR) gene are associated with an increased response to gefitinib in patients with non-small cell lung cancer. We have examined the impact of gefitinib ...
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