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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共28条记录   Structural Analysis of the Smad2-MAN1 Interaction That Regulates Transforming Growth Factor-beta Signaling at the Inner Nuclear Membrane [作者：Konde, E; Bourgeois, B; Tellier-Lebegue, C; Wu, W; Perez, J; Caputo, S; Attanda, W; Gasparini, S; Charbonnier, JB; Gilquin, B; Worman, HJ; Zinn-Justin, S,期刊：Biochemistry, 页码：8020-8032 , 文章类型： Article，,卷期：2010年49-37] MAN1, an integral protein of the inner nuclear membrane, influences transforming growth factor-beta (TGF-beta) signaling by directly interacting with R-Smads. Heterozygous loss of function mutations in the gene encoding ... Backbone Amide Dynamics Studies of Apo-L75F-TrpR, a Temperature-Sensitive Mutant of the Tryptophan Repressor Protein (TrpR): Comparison with the N-15 NMR Relaxation Profiles of Wild-Type and A77V Mutant Apo-TrpR Repressors [作者：Goel, A; Tripet, BP; Tyler, RC; Nebert, LD; Copie, V,期刊：Biochemistry, 页码：8006-8019 , 文章类型： Article，,卷期：2010年49-37] Backbone amide dynamics studies were conducted on a temperature-sensitive mutant (L75F-TrpR) of the tryptophan repressor protein (TrpR) of Escherichia coli in its apo (i.e., no L-tryptophan corepressor-bound) form. The N... Multiconformation Continuum Electrostatics Analysis of the Effects of a Buried Asp Introduced near Heme a in Rhodobacter sphaeroides Cytochrome c Oxidase [作者：Zhang, J; Gunner, MR,期刊：Biochemistry, 页码：8043-8052 , 文章类型： Article，,卷期：2010年49-37] Cytochrome c oxidase (CcO) reduces O-2 to water via a series of proton-coupled electron transfers, generating a transmembrane electrochemical gradient. Coupling electron and proton transfer requires changing the pK(a) va... Distinct Extracytoplasmic Siderophore Binding Proteins Recognize Ferrioxamines and Ferricoelichelin in Streptomyces coelicolor A3(2) [作者：Patel, P; Song, LJ; Challis, GL,期刊：Biochemistry, 页码：8033-8042 , 文章类型： Article，,卷期：2010年49-37] Under iron limitation, the Gram-positive bacterium Streptomyces coelicolor A3(2) excretes three siderophores of the hydroxamate type: desferrioxamine B, desferrioxamine E, and coelichelin. These sequester iron from insol... Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes [作者：Noguchi, T; Michihata, T; Nakamura, W; Takumi, T; Shimizu, R; Yamamoto, M; Ikeda, M; Ohmiya, Y; Nakajima, Y,期刊：Biochemistry, 页码：8053-8061 , 文章类型： Article，,卷期：2010年49-37] We have established a dual-color transgenic mouse that simultaneously reports the expression of two clock genes, Bmal1 and Per2, in a single tissue. The expression of the two genes is monitored with green- and red-emitti... Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in Neisseria gonorrhoeae: Role of Epistatic Mutations [作者：Tomberg, J; Unemo, M; Davies, C; Nicholas, RA,期刊：Biochemistry, 页码：8062-8070 , 文章类型： Article，,卷期：2010年49-37] Mutations in penicillin-binding protein 2 (PBP 2) encoded by mosaic penA alleles are crucial for intermediate resistance to the expanded-spectrum cephalosporins ceftriaxone and cefixime in Neisseria gonorrhoeae. Three of... Characterization of Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway [作者：Borisova, SA; Liu, HW,期刊：Biochemistry, 页码：8071-8084 , 文章类型： Article，,卷期：2010年49-37] The in vitro characterization of the catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces v... Bronsted Analysis and Rate-Limiting Steps for the T5 Flap Endonuclease Catalyzed Hydrolysis of Exonucleolytic Substrates [作者：Sengerova, B; Tomlinson, C; Atack, JM; Williams, R; Sayers, JR; Williams, NH; Grasby, JA,期刊：Biochemistry, 页码：8085-8093 , 文章类型： Article，,卷期：2010年49-37] During replication and repair flap endonucleases (FENs) catalyze endonucleolytic and exonucleolytic (EXO) DNA hydrolyses. Altering the leaving group pK(a), by replacing the departing nucleoside with analogues, had minima... Crystal Structures of Covalent Complexes of beta-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic Specificity [作者：Nicola, G; Tomberg, J; Pratt, RF; Nicholas, RA; Davies, C,期刊：Biochemistry, 页码：8094-8104 , 文章类型： Article，,卷期：2010年49-37] Penicillin-binding proteins (PBPs) are the molecular targets for the widely used beta-lactam class of antibiotics, but how these compounds act at the molecular level is not fully understood. We have determined crystal... Kinetic Analysis Reveals Differences in the Binding Mechanism of Calmodulin and Calmodulin-like Protein to the IQ Motifs of Myosin-10 [作者：Caride, AJ; Bennett, RD; Strehler, EE,期刊：Biochemistry, 页码：8105-8116 , 文章类型： Article，,卷期：2010年49-37] Myo10 is an unconventional myosin with important functions in filopodial motility, cell migration, and cell adhesion. The neck region of Myo10 contains three IQ motifs that bind calmodulin (CaM) or the tissue-restricted ... The Flavanol (-)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity [作者：Meng, FL; Abedini, A; Plesner, A; Verchere, CB; Raleigh, DP,期刊：Biochemistry, 页码：8127-8133 , 文章类型： Article，,卷期：2010年49-37] Islet amyloid polypeptide (IAPP, amylin) is the major protein component of the islet amyloid deposits associated with type 2 diabetes. The polypeptide lacks a well-defined structure in its monomeric state but readily ass... Redox Reactions of the alpha-Synuclein-Cu2+ Complex and Their Effects on Neuronal Cell Viability [作者：Wang, CS; Liu, L; Zhang, L; Peng, Y; Zhou, FM,期刊：Biochemistry, 页码：8134-8142 , 文章类型： Article，,卷期：2010年49-37] alpha-Synuclein (alpha-syn), a presynaptic protein believed to play an important role in neuropathology in Parkinson's disease (PD), is known to bind Cu2+. Cu2+ has been shown to accelerate the aggregation of alpha-syn t... Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA [作者：Karalewitz, APA; Kroken, AR; Fu, ZJ; Baldwin, MR; Kim, JJP; Barbieri, JT,期刊：Biochemistry, 页码：8117-8126 , 文章类型： Article，,卷期：2010年49-37] The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the... Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the Bacillus subtilis RNase P RNA Specificity Domain [作者：Liang, RT; Kierzek, E; Kierzek, R; Turner, DH,期刊：Biochemistry, 页码：8155-8168 , 文章类型： Article，,卷期：2010年49-37] Microarrays with isoenergetic pentamer and hexamer 2'-O-methyl oligonucleotide probes with LNA (locked nucleic acid) and 2,6-diaminopurine substitutions were used to probe the binding sites on the RNase P RNA specificity... Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein [作者：Geitmann, M; Retra, K; de Kloe, GE; Homan, E; Smit, AB; de Esch, IJP; Danielson, UH,期刊：Biochemistry, 页码：8143-8154 , 文章类型： Article，,卷期：2010年49-37] The mechanism of agonist interactions with Cys-loop ligand-gated ion channels has been studied using the acetylcholine-binding protein (AChBP) from Lymnaea stagnalis as a model protein and acetylcholine, nicotine, epibat... Kinetic Analysis of 14-3-3-Inhibited Arabidopsis thaliana Nitrate Reductase [作者：Lambeck, I; Chi, JC; Krizowski, S; Mueller, S; Mehlmer, N; Teige, M; Fischer, K; Schwarz, G,期刊：Biochemistry, 页码：8177-8186 , 文章类型： Article，,卷期：2010年49-37] Eukaryotic assimilatory nitrate reductase (NR) is a dimeric multidomain molybdo-heme-flavo protein that catalyzes the first and rate-limiting step in the nitrate assimilation of plants, algae, and fungi. Nitrate reductio...