- Docetaxel microemulsion for enhanced oral bioavailability: Preparation and in vitro and in vivo evaluation
[作者:Yin, YM; Cui, FD; Mu, CF; Choi, MK; Kim, JS; Chung, SJ; Shim, CK; Kim, DD,期刊:Journal of controlled release, 页码:86-94 , 文章类型: Article,,卷期:2009年140-2]
- A microemulsion system of docetaxel was prepared and evaluated for its solubilization capacity and oral bioavailability improvement. Based on a solubility study and pseudo ternary phase diagrams, microemulsions of about ...
- Tumor regression after systemic administration of tocotrienol entrapped in tumor-targeted vesicles
[作者:Fu, JY; Blatchford, DR; Tetley, L; Dufes, C,期刊:Journal of controlled release, 页码:95-99 , 文章类型: Article,,卷期:2009年140-2]
- The therapeutic potential of tocotrienol, an extract of vitamin E with anti-cancer properties, is hampered by its failure to specifically reach tumors after intravenous administration, without secondary effects on normal...
- Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow
[作者:Ferrante, EA; Pickard, JE; Rychak, J; Klibanov, A; Ley, K,期刊:Journal of controlled release, 页码:100-107 , 文章类型: Article,,卷期:2009年140-2]
- To improve ultrasound contrast agents targeted to the adhesion molecules P-selectin and VCAM-I for the purpose of molecular imaging of atherosclerotic plaques, perfluorocarbon-filled phospholipid microbubble contrast age...
- PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats
[作者:Kaminskas, LM; Kota, J; McLeod, VM; Kelly, BD; Karellas, P; Porter, CJH,期刊:Journal of controlled release, 页码:108-116 , 文章类型: Article,,卷期:2009年140-2]
- Polylysine dendrimers have potential as highly flexible, biodegradable nanoparticular carriers that may also promote lymphatic transport. The current study was undertaken to determine the impact of PEGylation on the abso...
- Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine
[作者:Hagenaars, N; Verheul, RJ; Mooren, I; de Jong, PHJLF; Mastrobattista, E; Glansbeek, HL; Heldens, JGM; van den Bosch, H; Hennink, WE; Jiskoot, W,期刊:Journal of controlled release, 页码:126-133 , 文章类型: Article,,卷期:2009年140-2]
- The aim of this study was to assess the influence of structural properties of N,N,N-trimethyl chitosan (TMC) on its adjuvanticity. Therefore, TMCs with varying degrees of quaternization (DQ, 22-86%), O-methylation (DOM, ...
- Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein delivery
[作者:Gao, XJ; Zhang, XE; Wu, ZM; Zhang, XJ; Wang, Z; Li, CX,期刊:Journal of controlled release, 页码:141-147 , 文章类型: Article,,卷期:2009年140-2]
- Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by se...
- Development and characterization of novel carrier gel core liposomes based transmission blocking malaria vaccine
[作者:Tiwari, S; Goyal, AK; Mishra, N; Khatri, K; Vaidya, B; Mehta, A; Wu, YM; Vyas, SP,期刊:Journal of controlled release, 页码:157-165 , 文章类型: Article,,卷期:2009年140-2]
- The aim of present work was to investigate the potential utility of novel carrier gel core liposomes for intramuscular delivery of transmission blocking malaria antigen Pfs25 and to evaluate the effect of co-administrati...
- Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
[作者:Danhier, F; Vroman, B; Lecouturier, N; Crokart, N; Pourcelle, V; Freichels, H; Jerome, C; Marchand-Brynaert, J; Feron, O; Preat, V,期刊:Journal of controlled release, 页码:166-173 , 文章类型: Article,,卷期:2009年140-2]
- Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol (R). The aim of this study was to test the hypothesis that our PEGylated PL...
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